Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana

Devkota KP, Lenta BN, Wansi J, Choudhary MI, Kisangau DP, Naz Q, Samreen, Sewald N (2008)
JOURNAL OF NATURAL PRODUCTS 71(8): 1481-1484.

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Abstract
The bioassay-guided phytochemical investigation of Sarcococca hookeriana with respect to cholinesterase inhibitory properties has yielded two new 5 alpha-pregnane-type steroidal alkaloids, hookerianamides J (1) and K (2), along with eight known Compounds (3-10). The structures of I and 2 were elucidated by spectroscopic methods. These compounds displayed good to moderate activities in vitro against the enzymes acetylcholinesterase IC50 8.1-48.5 mu M) and butyrylcholinesterase IC50 0.4-4.0 mu M). Compounds 1-10 were also tested in vitro for their leishmanicidal activity against Leishmania major and for their antibacterial activities against Bacillus subtilis, Micrococcus luteus, Streptococcus faecalis, and Pseudomonas pallida.
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Devkota KP, Lenta BN, Wansi J, et al. Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS. 2008;71(8):1481-1484.
Devkota, K. P., Lenta, B. N., Wansi, J., Choudhary, M. I., Kisangau, D. P., Naz, Q., Samreen,, et al. (2008). Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS, 71(8), 1481-1484.
Devkota, K. P., Lenta, B. N., Wansi, J., Choudhary, M. I., Kisangau, D. P., Naz, Q., Samreen,, and Sewald, N. (2008). Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS 71, 1481-1484.
Devkota, K.P., et al., 2008. Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS, 71(8), p 1481-1484.
K.P. Devkota, et al., “Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana”, JOURNAL OF NATURAL PRODUCTS, vol. 71, 2008, pp. 1481-1484.
Devkota, K.P., Lenta, B.N., Wansi, J., Choudhary, M.I., Kisangau, D.P., Naz, Q., Samreen,, Sewald, N.: Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana. JOURNAL OF NATURAL PRODUCTS. 71, 1481-1484 (2008).
Devkota, Krishna P., Lenta, Bruno N., Wansi, Jean, Choudhary, Muhammad I., Kisangau, Daniel P., Naz, Qamar, Samreen,, and Sewald, Norbert. “Bioactive 5 alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana”. JOURNAL OF NATURAL PRODUCTS 71.8 (2008): 1481-1484.
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