How T-cells use large deviations to recognize foreign antigens

Zint N, Baake E, den Hollander F (2008)
JOURNAL OF MATHEMATICAL BIOLOGY 57(6): 841-861.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
A stochastic model for the activation of T-cells is analysed. T-cells are part of the immune system and recognize foreign antigens against a background of the body's own molecules. The model under consideration is a slight generalization of a model introduced by Van den Berg et al. (J Theor Biol 209:465-486, 2001), and is capable of explaining how this recognition works on the basis of rare stochastic events. With the help of a refined large deviation theorem and numerical evaluation it is shown that, for a wide range of parameters, T-cells can distinguish reliably between foreign antigens and self-antigens.
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Zeitschriftentitel
JOURNAL OF MATHEMATICAL BIOLOGY
Band
57
Zeitschriftennummer
6
Seite
841-861
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eISSN
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Zint N, Baake E, den Hollander F. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 2008;57(6):841-861.
Zint, N., Baake, E., & den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), 841-861. doi:10.1007/s00285-008-0191-1
Zint, N., Baake, E., and den Hollander, F. (2008). How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY 57, 841-861.
Zint, N., Baake, E., & den Hollander, F., 2008. How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY, 57(6), p 841-861.
N. Zint, E. Baake, and F. den Hollander, “How T-cells use large deviations to recognize foreign antigens”, JOURNAL OF MATHEMATICAL BIOLOGY, vol. 57, 2008, pp. 841-861.
Zint, N., Baake, E., den Hollander, F.: How T-cells use large deviations to recognize foreign antigens. JOURNAL OF MATHEMATICAL BIOLOGY. 57, 841-861 (2008).
Zint, Natali, Baake, Ellen, and den Hollander, Frank. “How T-cells use large deviations to recognize foreign antigens”. JOURNAL OF MATHEMATICAL BIOLOGY 57.6 (2008): 841-861.

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Stochastic modelling of T-cell activation.
Mayer H, Bovier A., J Math Biol 70(1-2), 2015
PMID: 24500058
Chemodetection in fluctuating environments: receptor coupling, buffering, and antagonism.
Lalanne JB, François P., Proc Natl Acad Sci U S A 112(6), 2015
PMID: 25624502

27 References

Daten bereitgestellt von Europe PubMed Central.

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.
Wu LC, Tuot DS, Lyons DS, Garcia KC, Davis MM., Nature 418(6897), 2002
PMID: 12152083

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