Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system

Rehder D, Haupt ETK, Müller A (2008)
MAGNETIC RESONANCE IN CHEMISTRY 46(S1): S24-S29.

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Li+ ions can interplay with other cations intrinsically present in the intra- and extra-cellular space (i.e. Na+, K+, Mg2+ and Ca2+) and have therapeutic effects (e.g. in the treatment of bipolar disorder) or toxic effects (at higher doses), likely because Li+ interferes with the intra-/extra-cellular concentration gradients of the mentioned physiologically relevant cations. The cellular transmembrane transport can be modelled by molybdenum-oxide-based Keplerates, i.e. nano-sized porous capsules containing 132 Mo centres, monitored through Li-6/7 as well as Na-23 NMR spectroscopy. The effects on the transport of Li+ cations through the 'ion channels' of these model cells, caused by variations in water amount, temperature, and by the addition of organic cationic 'plugs' and the shift reagent [Dy(PPP)(2)](7-) are reported. In the investigated solvent systems, water acts as a transport mediator for Li+. Likewise, the counter-transport (Li+/Na+, Li+/K+, Li+/Cs+ and Li+/Ca2+) has been investigated by Li-7 NMR and, in the case of Li+/Na+ exchange, by Na-23 NMR, and it has been shown that most (in the case of Na+ and K+), all (Ca2+) or almost none (Cs+) of the Li cations is extruded from the internal sites of the artificial cell to the extra-cellular medium, while Na+, K+ and Ca2+ are partially incorporated. Copyright (C) 2008 John Wiley & Sons, Ltd.
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Rehder D, Haupt ETK, Müller A. Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY. 2008;46(S1):S24-S29.
Rehder, D., Haupt, E. T. K., & Müller, A. (2008). Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY, 46(S1), S24-S29.
Rehder, D., Haupt, E. T. K., and Müller, A. (2008). Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY 46, S24-S29.
Rehder, D., Haupt, E.T.K., & Müller, A., 2008. Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY, 46(S1), p S24-S29.
D. Rehder, E.T.K. Haupt, and A. Müller, “Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system”, MAGNETIC RESONANCE IN CHEMISTRY, vol. 46, 2008, pp. S24-S29.
Rehder, D., Haupt, E.T.K., Müller, A.: Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system. MAGNETIC RESONANCE IN CHEMISTRY. 46, S24-S29 (2008).
Rehder, Dieter, Haupt, Erhard T. K., and Müller, Achim. “Cellular cation transport studied by Li-6,Li-7 and Na-23 NMR in a porous Mo-132 Keplerate type nano-capsule as model system”. MAGNETIC RESONANCE IN CHEMISTRY 46.S1 (2008): S24-S29.
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