233 Publikationen

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  • [233]
    2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2986983
    Blöbaum L, Torello Pianale L, Olsson L, Grünberger A. Quantifying microbial robustness in dynamic environments using microfluidic single-cell cultivation. Microbial Cell Factories . 2024;23(1): 44.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [232]
    2023 | Preprint | Veröffentlicht | PUB-ID: 2985556
    Nieto C, Täuber S, Blöbaum L, Vahdat Z, Grünberger A, Singh A. Coupling Cell Size Regulation and Proliferation Dynamics of Reveals Cell Division Based on Surface Area. bioRxiv. 2023.
    PUB | DOI | PubMed | Europe PMC
     
  • [231]
    2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2968932 OA
    Steinhoff H, Finger M, Osthege M, et al. Experimental ks estimation: A comparison of methods for Corynebacterium glutamicum from lab to microfluidic scale. Biotechnology and Bioengineering. 2023;120(5):1167-1449.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [230]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2982187
    Blöbaum L, Täuber S, Grünberger A. Protocol to perform dynamic microfluidic single-cell cultivation of C.glutamicum. STAR Protocols . 2023;4(3): 102436.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [229]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2969695
    Täuber S, Grünberger A. Microfluidic single-cell scale-down systems: introduction, application, and future challenges. Current Opinion in Biotechnology. 2023;81: 102915.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [228]
    2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2964098 OA
    Täuber S, Blöbaum L, Steier V, Oldiges M, Grünberger A. Microfluidic single-cell scale-down bioreactors: A proof-of-concept for the growth of Corynebacterium glutamicum at oscillating pH values. Biotechnology and Bioengineering. 2022;119(11):3194-3209.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC | Preprint
     
  • [227]
    2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2963033 OA
    Smaluch K, Wollenhaupt B, Steinhoff H, Kolhheyer D, Grünberger A, Dusny C. Assessing the growth kinetics and stoichiometry of Escherichia coli at the single-cell level. Engineering in Life Sciences . 2022.
    PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
     
  • [226]
    2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962620 OA
    Karsten L, Gött-Zink L, Schmitz J, et al. Genetically Encoded Ratiometric pH Sensors for the Measurement of Intra- and Extracellular pH and Internalization Rates. Biosensors. 2022;12(5): 271.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [225]
    2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2967671
    Blöbaum L, Haringa C, Grünberger A. Microbial lifelines in bioprocesses: From concept to application. Biotechnology Advances. 2022;62.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [224]
    2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2963556 OA
    Romanova N, Schmitz J, Strakeljahn M, Grünberger A, Bahnemann J, Noll T. Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response. Cells. 2022;11(11): 1763.
    PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
     
  • [223]
    2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2964097
    Ho P, Täuber S, Stute B, Grünberger A, von Lieres E. Microfluidic Reproduction of Dynamic Bioreactor Environment Based on Computational Lifelines. Frontiers in Chemical Engineering. 2022;4: 826485.
    PUB | DOI
     
  • [222]
    2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2962029
    Bahnemann J, Grünberger A. Microfluidics in Biotechnology: Overview and Status Quo. Advances in Biochemical Engineering, Biotechnology . 2022:1-16.
    PUB | DOI | PubMed | Europe PMC
     
  • [221]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2956409 OA
    Schmitz J, Höving AL, Schmidt KE, et al. Human Blood Serum Induces p38-MAPK- and Hsp27-Dependent Migration Dynamics of Adult Human Cardiac Stem Cells: Single-Cell Analysis via a Microfluidic-Based Cultivation Platform. Biology. 2021;10(8): 708.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [220]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2956806 OA
    Hermann KM, Grünberger A, Patel A. Formalin-casein enhances water absorbency of calcium alginate beads and activity of encapsulated Metarhizium brunneum and Saccharomyces cerevisiae. World Journal of Microbiology and Biotechnology. 2021;37(9): 156.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [219]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2967242
    Dietsch R, Jakobs-Schoenwandt D, Grünberger A, Patel A. Desiccation-tolerant fungal blastospores: From production to application. Current Research in Biotechnology. 2021;3:323-339.
    PUB | DOI | WoS
     
  • [218]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2957323 OA
    Täuber S, Blöbaum L, Wendisch VF, Grünberger A. Growth response and recovery of Corynebacterium glutamicum colonies on single-cell level upon defined pH stress pulses. Frontiers in Microbiology. 2021;12:711893.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC | Preprint
     
  • [217]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2959820 OA
    Täuber S, Schmitz J, Blöbaum L, Fante N, Steinhoff H, Grünberger A. How to Perform a Microfluidic Cultivation Experiment—A Guideline to Success. Biosensors. 2021;11(12): 485.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [216]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2955090 OA
    Schmitz J, Hertel O, Yermakov B, Noll T, Grünberger A. Growth and eGFP-production of CHO-K1 suspension cells cultivated from single-cell to laboratory scale. Frontiers in Bioengineering and Biotechnology. 2021;9: 716343.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC | Preprint
     
  • [215]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2964708 OA
    Blöbaum L, Täuber S, Grünberger A. Ein Wechselbad für Mikroben: Wachsen unter dynamischen Umweltbedingungen. BIOspektrum. 2021;27(5):491-493.
    PUB | PDF | DOI
     
  • [214]
    2021 | Zeitschriftenaufsatz | Im Druck | PUB-ID: 2957505
    Blombach B, Grünberger A, Centler F, Wierckx N, Schmid J. Exploiting unconventional prokaryotic hosts for industrial biotechnology. Trends in biotechnology. In Press.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [213]
    2021 | Zeitschriftenaufsatz | Angenommen | PUB-ID: 2955245
    Stallmann D, Göpfert JP, Schmitz J, Grünberger A, Hammer B. Towards an automatic analysis of CHO-K1 suspension growth in microfluidic single-cell cultivation. Bioinformatics . Accepted.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [212]
    2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2951549
    Schlembach I, Grünberger A, Rosenbaum MA, Regestein L. Measurement Techniques to Resolve and Control Population Dynamics of Mixed-Culture Processes. Trends in Biotechnology. 2021.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [211]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2957513
    Lenz P, Hilgers F, Burmeister A, et al. The iSplit GFP assay detects intracellular recombinant proteins in Bacillus subtilis. Microbial cell factories. 2021;20(1): 174.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [210]
    2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2955524
    Burmeister A, Akhtar Q, Hollmann L, et al. (Optochemical) Control of Synthetic Microbial Coculture Interactions on a Microcolony Level. ACS synthetic biology. 2021.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [209]
    2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2955913
    Nguyen TM, Telek S, Zicler A, et al. Reducing phenotypic instabilities of a microbial population during continuous cultivation based on cell switching dynamics. Biotechnology and bioengineering. 2021.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [208]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949089 OA
    Schmitz J, Täuber S, Westerwalbesloh C, von Lieres E, Noll T, Grünberger A. Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution. Biotechnology and Bioengineering. 2021;118(2):992-1005.
    PUB | Dateien verfügbar | DOI | WoS | PubMed | Europe PMC | Preprint
     
  • [207]
    2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2951151
    Winkler S, Grünberger A, Bahnemann J. Microfluidics in Biotechnology: Quo Vadis. Advances in biochemical engineering/biotechnology. 2021:1-26.
    PUB | DOI | PubMed | Europe PMC
     
  • [206]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2946333 OA
    Della Corte D, van Beek HL, Syberg F, et al. Engineering and application of a biosensor with focused ligand specificity. Nature communications. 2020;11(1): 4851.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [205]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948721 OA
    Ortseifen V, Viefhues M, Wobbe L, Grünberger A. Microfluidics for Biotechnology: Bridging Gaps to Foster Microfluidic Applications. Frontiers in Bioengineering and Biotechnology. 2020;8: 589074.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [204]
    2020 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2948408
    Täuber S, Golze C, Ho P, von Lieres E, Grünberger A. dMSCC: a microfluidic platform for microbial single-cell cultivation of Corynebacterium glutamicum under dynamic environmental medium conditions. Lab on a chip. 2020.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [203]
    2020 | Preprint | Veröffentlicht | PUB-ID: 2944674
    Täuber S, Golze C, Ho P, von Lieres E, Grünberger A. dMSCC: A microfluidic platform for microbial single-cell cultivation under dynamic environmental medium conditions. bioRxiv. 2020.
    PUB | DOI | Preprint
     
  • [202]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944673 OA
    Täuber S, Dormeyer M, Commichau FM, Grünberger A. Visualisierung von Mutationen auf Einzelzellebene. BIOspektrum. 2020;26(4):388-390.
    PUB | PDF | DOI
     
  • [201]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2941821 OA
    Täuber S, Lieres E, Grünberger A. Dynamic Environmental Control in Microfluidic Single‐Cell Cultivations: From Concepts to Applications. Small. 2020;16(16): 1906670.
    PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
     
  • [200]
    2020 | Zeitschriftenaufsatz | Im Druck | PUB-ID: 2939030
    Burmeister A, Grünberger A. Microfluidic cultivation and analysis tools for interaction studies of microbial co-cultures. Current opinion in biotechnology. In Press;62:106-115.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [199]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2937575 OA
    Hilgers F, Bitzenhofer NL, Ackermann Y, et al. Genetically Encoded Photosensitizers as Light-Triggered Antimicrobial Agents. International journal of molecular sciences. 2019;20(18): 4608.
    PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
     
  • [198]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936034
    Lindemann D, Westerwalbesloh C, Kohlheyer D, Grünberger A, von Lieres E. Microbial single-cell growth response at defined carbon limiting conditions. RSC ADVANCES. 2019;9(25):14040-14050.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [197]
    2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2935887
    Sassi H, Nguyen TM, Telek S, Gosset G, Grünberger A, Delvigne F. Segregostat: a novel concept to control phenotypic diversification dynamics on the example of Gram-negative bacteria. Microbial biotechnology. 2019;12(5):1064-1075.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [196]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935495
    Ho P, Westerwalbesloh C, Kaganovitch E, et al. Reproduction of Large-Scale Bioreactor Conditions on Microfluidic Chips. Microorganisms. 2019;7(4): 105.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [195]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2937237
    Sachs CC, Koepff J, Wiechert W, Grünberger A, Noh K. mycelyso - high-throughput analysis of Streptomyces mycelium live cell imaging data. BMC bioinformatics. 2019;20(1): 452.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [194]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934065
    Jager VD, Kloss R, Grünberger A, et al. Tailoring the properties of (catalytically)-active inclusion bodies. Microbial cell factories. 2019;18(1): 33.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [193]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2939585
    Dusny C, Grünberger A. Microfluidic single-cell analysis in biotechnology: from monitoring towards understanding. Current opinion in biotechnology. 2019;63:26-33.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [192]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2937529
    Schmitz J, Grünberger A. Ich sehe 'was, was du nicht siehst. LABO. 2019;51(9):30-33.
    PUB
     
  • [191]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935496
    Westerwalbesloh C, Brehl C, Weber S, et al. A microfluidic photobioreactor for simultaneous observation and cultivation of single microalgal cells or cell aggregates. PloS one. 2019;14(4): e0216093.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [190]
    2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933358
    Schmitz J, Noll T, Grünberger A. Heterogeneity Studies of Mammalian Cells for Bioproduction. From Tools to Application. Trends in Biotechnology. 2019;37(6):645-660.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [189]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2935584
    Theorell A, Seiffarth J, Grünberger A, Noeh K. When a single lineage is not enough: Uncertainty-Aware Tracking for spatio-temporal live-cell image analysis. BIOINFORMATICS. 2019;35(7):1221-1228.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [188]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932955
    Burmeister A, Hilgers F, Langner A, et al. A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments. LAB ON A CHIP. 2019;19(1):98-110.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [187]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920273
    Kloss R, Limberg MH, Mackfeld U, et al. Catalytically active inclusion bodies of L-lysine decarboxylase from E. coli for 1,5-diaminopentane production. SCIENTIFIC REPORTS. 2018;8(1): 5856.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [186]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932416
    Kampf J, Gerwig J, Kruse K, et al. Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability. mBio. 2018;9(5): e01464-18.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [185]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920685
    Mosheiff N, Martins BMC, Pearl-Mizrahi S, et al. Inheritance of Cell-Cycle Duration in the Presence of Periodic Forcing. PHYSICAL REVIEW X. 2018;8(2): 15.
    PUB | DOI | WoS
     
  • [184]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932764 OA
    Koepff J, Sachs CC, Wiechert W, et al. Germination and Growth Analysis of Streptomyces lividans at the Single-Cell Level Under Varying Medium Compositions. FRONTIERS IN MICROBIOLOGY. 2018;9: 2680.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [183]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2930515
    Hage-Huelsmann J, Grünberger A, Thies S, et al. Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants. PLOS ONE. 2018;13(7): e0200940.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [182]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919078
    Hornung R, Grünberger A, Westerwalbesloh C, Kohlheyer D, Gompper G, Elgeti J. Quantitative modelling of nutrient-limited growth of bacterial colonies in microfluidic cultivation. JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2018;15(139): 11.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [181]
    2018 | Konferenzbeitrag | PUB-ID: 2933363
    Schmitz J, Noll T, Grünberger A. Towards Microfluidic Single-Cell Cultivation of Mammalian Cell Lines. Presented at the Young Scientist Cell Culture Biotechnology Retreat, Laupheim.
    PUB
     
  • [180]
    2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933359
    Schmitz J, Kerkhoff Y, Noll T, Kohlheyer D, Grünberger A. Towards dynamic single-cell cultivation systems for industrially relevant mammalian cell lines. Presented at the BioProcessing Days 2018, Recklinghausen.
    PUB
     
  • [179]
    2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933362
    Schmitz J, Kerkhoff Y, Noll T, Grünberger A. Dynamic microfluidical single-cell cultivation of mammalian cell lines. From experiment to analysis. Presented at the CeBiTec Symposium 2018, Bielefeld.
    PUB
     
  • [178]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932765
    Kloss R, Karmainski T, Jaeger VD, et al. Tailor-made catalytically active inclusion bodies for different applications in biocatalysis. CATALYSIS SCIENCE & TECHNOLOGY. 2018;8(22):5816-5826.
    PUB | DOI | WoS
     
  • [177]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931505
    Jaeger VD, Lamm R, Kloss R, et al. A Synthetic Reaction Cascade Implemented by Colocalization of Two Proteins within Catalytically Active Inclusion Bodies. ACS SYNTHETIC BIOLOGY. 2018;7(9):2282-2295.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [176]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919063
    Dormeyer M, Lentes S, Ballin P, et al. Visualization of tandem repeat mutagenesis in Bacillus subtilis. DNA REPAIR. 2018;63:10-15.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [175]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912521
    Grünberger A, Schöler K, Probst C, et al. Real-time monitoring of fungal growth and morphogenesis at single-cell resolution. Engineering in life sciences. 2017;17(1):86–92.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [174]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912738
    Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E. Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level. Microbial Biotechnology. 2017;10(4):845-857.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [173]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916519
    Binder D, Drepper T, Jaeger K-E, et al. Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity. METABOLIC ENGINEERING. 2017;42:145-156.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [172]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912503
    Rudat A, Wiechert W, Kohlheyer D, Grünberger A. Picoliter bioreactors for microbial consortia: From proof of concept to first application. Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
    PUB
     
  • [171]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912508
    Burmeister A, Bitzenhofer NL, Grünberger A, et al. Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level. Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
    PUB
     
  • [170]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912759
    Grünberger A. Microfluidic Single-Cell Cultivation: A key for next generation bioprocess development? Presented at the FFBiotech Symposium - Innovative approaches in bioreactors design and operation, Lille, France.
    PUB
     
  • [169]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912771
    Rudat A, Noack S, Wiechert W, Kohlheyer D, Grünberger A. Microfluidic single-cell (co-)cultivation: Exploring the next dimension. Presented at the Data-driven Biotechnology - bench, bioreactor and bedside, Copenhagen, Denmark.
    PUB
     
  • [168]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912502
    Jäger VD, Longerich S, Dietrich M, et al. Functionally-active protein aggregates - towards the realization of an enzyme cascade in catalytically-active inclusion bodies. Presented at the BioTrans 2017, Budapest, Hungary.
    PUB
     
  • [167]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912505
    Sachs CC, Koepff J, Kohlheyer D, et al. Microfluidic single-cell cultivation of S. lividans: Uncovering heterogeneity in filamentous growth. Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
    PUB
     
  • [166]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912507
    Rudat A, Wiechert W, Kohlheyer D, Grünberger A. Spatiotemporal analysis of synthetic microbial communities at the single-cell level in microfluidic interaction compartments. Presented at the 6th International Conference on Microbial Communication for Young Scientists, Jena, Germany.
    PUB
     
  • [165]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912501
    Kloss R, Limberg M, Jäger VD, et al. Catalytically active inclusion bodies. A novel carrier-free Enzyme Immobilisation method. Presented at the BioTrans 2017, Budapest, Hungary.
    PUB
     
  • [164]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912506
    Sachs CC, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Nöh K. Integrated High-Throughput Platform for Microfluidic Live-Cell Analysis with Feed-Back Eyperimentation. Presented at the DECHEMA-Tagung "Systems Biology meets Synthetic Biology", Frankfurt, Germany.
    PUB
     
  • [163]
    2017 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912518
    Kaganovitch E, Krischer M, Probst C, et al. Microfluidic device for control and sensing of dynamic oxygen levels during cell cultivation. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). Red Hook, NY: Curran Associates, Inc.; 2017: 355-356.
    PUB
     
  • [162]
    2017 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2912520
    Ladner T, Grünberger A, Probst C, Kohlheyer D, Büchs J, Delvigne F. Application of Mini- and Micro-Bioreactors for Microbial Bioprocesses. In: Larroche C, Sanromán MÁ, Du G, Pandey A, eds. Current Developments in Biotechnology and Bioengineering. Amsterdam: Elsevier; 2017: 433-461.
    PUB | DOI
     
  • [161]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912737
    Delvigne F, Baert J, Sassi H, Fickers P, Grünberger A, Dusny C. Taking control over microbial populations: Current approaches for exploiting biological noise in bioprocesses. Biotechnology Journal. 2017;12(7): 1600549.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [160]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912504
    Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E. Models for Developing and Optimizing Microscale Bacteria Cultivation. Presented at the Himmelfahrtstagung 2017: Models for Developing and Optimising Biotech Production, Neu-Ulm, Germany.
    PUB
     
  • [159]
    2017 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912509
    Rudat A, Wiechert W, Kohlheyer D, Grünberger A. Microfluidic cultivation chamber for the investigation of synthetic microbial co-cultures on single-cell level: From the development to first application. Presented at the BioProcessing Days 2017, Recklinghausen, Germany.
    PUB
     
  • [158]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912514 OA
    Binder D, Probst C, Grünberger A, et al. Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation. PLoS one. 2016;11(8): e0160711.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [157]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912522 OA
    Sachs CC, Grünberger A, Helfrich S, et al. Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments. PLoS one. 2016;11(9): e0163453.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [156]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912513
    Kusen PM, Wandrey G, Probst C, et al. Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine. ACS chemical biology. 2016;11(10):2915-2922.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [155]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912527
    Grünberger A. Microfluidic single-cell cultivation: Is small the new beautiful? Presented at the 6th International Bielefeld-CeBiTec Research Conference: Advances in Industrial Biotechnology: New Techniques, Substrates and Products for Bioprocesses, Bielefeld, Germany.
    PUB
     
  • [154]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912534
    Grünberger A. Single-cell microfluidics for bioprocess development. Presented at the GreenWin Conferences “Green Chemistry and White Biotechnology", Gembloux, Belgium.
    PUB
     
  • [153]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912539
    Westerwalbesloh C, Grünberger A, Stute B, et al. Nutrient distribution in perfusion based picoliter bioreactors. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
    PUB
     
  • [152]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912820
    Hage-Hülsmann J, Grünberger A, Thies S, et al. Combinatorial antibiotic effects of natural biocide cocktails. Presented at the IV International Conference on Antimicrobial Research, Malaga, Spain.
    PUB
     
  • [151]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912761
    Grünberger A. Microfluidic single-cell bioreactors. Introduction, application and future perspectives. Presented at the LCSB Biannual Minisymposia in Modelling/Automation/Microfluidics at the University of Luxembourg, Esch-sur-Alzette, Luxembourg.
    PUB
     
  • [150]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912803
    Binder D, Bier C, Grünberger A, et al. Employing photocaged carbohydrates in light-controlled cell factories for synthetic bio(techno)logy and single cell applications. Presented at the Annual Conference of the Association for General and Applied Microbiology (VAAM),, Jena, Germany.
    PUB
     
  • [149]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912512
    Bier C, Binder D, Grünberger A, et al. Sugar Based Caged Compounds for Biotechnological Synthetic Biological Applications. Presented at the 26th IUPAC Symposium on Photochemistry, Osaka, Japan.
    PUB
     
  • [148]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912524
    Brehl C, Grünberger A, Probst C, et al. Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments. Presented at the 9. DECHEMA Bundesalgenstammtisch, Jülich, Germany.
    PUB
     
  • [147]
    2016 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912526
    Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E. Comparison of different cultivation chamber designs for microfluidic bioreactors. Chemie Ingenieur Technik. 2016;88(9):1390.
    PUB | DOI
     
  • [146]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912529
    Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D. Microbial metabolic state diagrams: Using microfluidic single-cell cultivation to predict bacterial gene expresssion. Presented at the EMBL Conference Microfluidics, Heidelberg, Germany.
    PUB
     
  • [145]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912531
    Westerwalbesloh C, Grünberger A, Kohlheyer D, von Lieres E. Modeling inhomogeneities across cultivation chamber arrays in single-cell cultivation devices. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
    PUB
     
  • [144]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912536
    Sachs CC, Probst C, Grünberger A, et al. An integrated platform for dynamic microfluidic experimentation with single-cell resolution. Presented at the DECHEMA-Tagung 'Single Cell Technologies 2016', Frankfurt, Germany.
    PUB
     
  • [143]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912538
    Steffens I, Grünberger A, Binder D, Drepper T, Wiechert W, Kohlheyer D. Bacterial phase diagrams. Analyzing and predicting cell-to-cell heterogeneity of microbial gene expression. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin (Germany).
    PUB
     
  • [142]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912540
    Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D. Bacterial phase diagrams – Using engineering concepts to predict cell-to-cell heterogeneity of microbial gene expression. Presented at the Jahrestagung 2016 der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Jena, Germany.
    PUB
     
  • [141]
    2016 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912552
    Probst C, Freier C, Mahr R, et al. Closing the gap between microfluidic single-cell analysis and bioprocess development for microbial organisms. In: 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015). Red Hook, NY: Curran Associates, Inc.; 2016: 537-539.
    PUB
     
  • [140]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912525
    Burmeister A, Bitzenhofer NL, Grünberger A, Binder D, Drepper T, Wiechert W. Microfluidic heterogeneity analysis of fluorescence-based gene expression of industrially relevant production strains on single-cell level. Presented at the 18. Heiligenstädter Kolloquium „Technische Systeme für die Lebenswissenschaften, Heiligenstadt, Germany.
    PUB
     
  • [139]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912532
    Westerwalbesloh C, Grünberger A, Stute B, Weber S, Kohlheyer D, von Lieres E. Characterizing substrate availability within microfluidic tools employed for the analysis of genetically modified single cells. Presented at the 1. International Conference on Molecular Interaction Engineering (MIE), Karlsruhe, Germany.
    PUB
     
  • [138]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912537
    Grünberger A, Wiechert W, Kohlheyer D. Bioprocesses under magnification. Learning from single cells about large-scale processes. Presented at the 4th BioProScale Symposium "Bioprocess intensification through process analytical technology (PAT) and quality by design (QbD)", Berlin, Germany.
    PUB
     
  • [137]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912544
    Binder D, Bier C, Grünberger A, et al. Photocaged Arabinose - A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression. ChemBioChem. 2016;17(4):296-299.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [136]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912739
    Li S, Jendresen CB, Grünberger A, et al. Enhanced protein and biochemical production using CRISPRi-based growth switches. Metabolic Engineering. 2016;38:274-284.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [135]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912760
    Grünberger A. Picoliter bioreactors for microbial consortia: A novel concept to investigate microbial interactions at the single-cell level. Presented at the SynComBio Workshop “Applications of synthetic microbial communities in bioeconomy", Düsseldorf, Germany.
    PUB
     
  • [134]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912772
    Grünberger A, Sachs C, Kohlheyer D, Wiechert W, Nöh K. Spatio-temporal analysis of bacterial populations at single-cell level. Presented at the IBG Modelling Workshop, Jülich, Germany.
    PUB
     
  • [133]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912511
    Bier C, Binder D, Grünberger A, et al. Photocaged Carbohydrates: Versatile Tools for Biotechnological Applications. Presented at the 18th International Conference on Photochemistry, Paris, France.
    PUB
     
  • [132]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912523
    Brehl C, Grünberger A, Probst C, et al. Microfluidic cultivation of the microalgae Chlorella sorokiniana on single-cell level at defined environments. Presented at the ProcessNet 2016, Aachen, Germany.
    PUB
     
  • [131]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912530
    Kaganovitch E, Probst C, Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D. Single-cell analysis of E. coli in microfluidic batch reactors. Presented at the EMBL Conference Microfluidics, Heidelberg (Germany.
    PUB
     
  • [130]
    2016 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912535
    Grünberger A, Steffens I, Binder D, Drepper T, Wiechert W, Kohlheyer D. Bacterial phase diagrams: A novel concept to predict and control bacterial gene expression. Presented at the DECHEMA-Himmelfahrtstagung: New Frontiers for Biotech Processes, Koblenz, Germany.
    PUB
     
  • [129]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904866
    Binder D, Frohwitter J, Mahr R, et al. Light-controlled cell factories – Employing photocaged IPTG for light-mediated optimization of lac-based gene expression and (+)-valencene biosynthesis in Corynebacterium glutamicum. Appl Environ Microbiol. 2016;82(20):6141-6149.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [128]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912584
    Probst C, Grünberger A, Braun N, et al. Rapid inoculation of single bacteria into parallel picoliter fermentation chambers. Analytical methods. 2015;7(1):91-98.
    PUB | DOI | WoS
     
  • [127]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912568
    Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A. Technical bias of microcultivation environments on single cell physiology. Lab on a chip. 2015;15(8):1822-1834.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [126]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912550
    Grünberger A, Probst C, Helfrich S, et al. Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform. Cytometry / A. 2015;87(12):1101–1115.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [125]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912554 OA
    Krämer CEM, Singh A, Helfrich S, et al. Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester. PLoS one. 2015;10(10): e0141768.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [124]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912555
    Helfrich S, Azzouzi CE, Probst C, et al. Vizardous: interactive analysis of microbial populations with single cell resolution. Bioinformatics. 2015;31(23):3875-3877: btv468.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [123]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912557 OA
    Westerwalbesloh C, Grünberger A, Stute B, et al. Modeling and CFD Simulation of nutrient Distribution in picoliter bioreactors for bacterial growth studies on single-cell level. Lab on a chip. 2015;15(21):4177-4186.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [122]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912541
    Binder D, Bier C, Grünberger A, et al. Light-controlled cell factories - Employing optogenetic plug-and-play expression modules based on photocaged carbohydrates for synthetic bio(techno)logy and single cell applications. Presented at the ESP Photobiology conference, Aveiro, Portugal.
    PUB
     
  • [121]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912546
    Grünberger A, Wiechert W, Kohlheyer D. Single-cell microfluidics: A key technology to understand life at environmental defined conditions. Presented at the Kick-off Konferenz: Leben? - Eine neue Förderinitiative stellt sich vor, Hannover, Germany.
    PUB
     
  • [120]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912560
    Zunic E, Schechtel A, Probst C, et al. Dynamic environmental control in microfluidic devices for single-cell Analysis of biological production processes. Presented at the Kolloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
    PUB
     
  • [119]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912565
    Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D. Single-cell microfluidics meets applied biotechnology. From expectation to application. Presented at the Conference "Cell Factories and Biosustainability - Technologies for Cell Factory Construction", Hillerod, Denmark.
    PUB
     
  • [118]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912773
    Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D. Single-cell microfluidics meets applied biotechnology. From expectation to application. Presented at the Jahreskongress Biotechnologie 2020+, Berlin, Germany.
    PUB
     
  • [117]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912545
    Loeschcke A, Thies S, Hage-Hülsmann J, et al. Heterologous production of antibacterial secondary metabolites from Serratia marcescens in Pseudomonas putida. Presented at the 6th Congress of European Microbiologists (FEMS 2015), Maastricht, Netherlands.
    PUB
     
  • [116]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912548
    Bier C, Binder D, Grünberger A, et al. Caged Compounds for Biotechnological and Synthetic Biological Applications. Presented at the European Society for Photobiology 2015 Congress, Aveiro, Portugal.
    PUB
     
  • [115]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912562
    Grünberger A. Einzelzell-Bioreaktoren - fast unsichtbar, aber nicht unscheinbar. Biospektrum. 2015;21(3):353-353.
    PUB | DOI
     
  • [114]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912567
    Grünberger A. Single-cell bioreactors: Improving the understanding of microbial metabolism. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg (Germany.
    PUB
     
  • [113]
    2015 | Dissertation | Veröffentlicht | PUB-ID: 2912574 OA
    Grünberger A. Single-Cell Analysis of Microbial Production Strains in Microfluidic Bioreactors. Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies. Vol 114. Jülich: RWTH Aachen; 2015.
    PUB | PDF
     
  • [112]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912549
    Mahr R, Mustafi N, Grünberger A, et al. Metabolite biosensors for single cell Analysis and the Evolution of production strains. Presented at the 30. Jahrestagung der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Marburg, Germany.
    PUB
     
  • [111]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912551
    Probst C, Grünberger A, Krämer C, et al. Genetically encoded sensor analysis with spatial and temporal Resolution by time-lapse imaging. Presented at the 1st Evaluation Symposium, Molecular Interaction Engineering, MIE-Project, Karlsruhe, Germany.
    PUB
     
  • [110]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912556
    Binder D, Probst C, Bier C, Loeschcke A, Grünberger A. Lichtgesteuerte Genexpression auf Einzelzellebene. Biospektrum. 2015;21(6):612-615.
    PUB | DOI
     
  • [109]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912563
    Sachs CC, Helfrich S, Grünberger A, et al. High-throughput, long-term growth characterization of C. glutamicum on single cell level using the Mother Machine. Presented at the 3rd International Conference of the Cluster of Excellence Tailor-Made Fuels from Biomass, Aachen, Germany.
    PUB
     
  • [108]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912804
    Krämer C, Helfrich S, Singh A, et al. Instantaneous microfluidic metabolic activity sensing for non-invasive single cell physiology analysis of a prokaryote and its descendants. Presented at the 3nd International Conference IMPLEMENTATION OF MICROREACTOR TECHNOLOGY INTO BIOTECHNOLOGY (IMTB 2015), Opatija, Croatia.
    PUB
     
  • [107]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912763
    Grünberger A. Microfluidic Single-Cell Cultivation: The key for next generation bioprocess development? Presented at the Colloquium Biotechnology, Technical Faculty - Bielefeld University, Bielefeld.
    PUB
     
  • [106]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912542
    Probst C, Grünberger A, Binder D, Steffen I, Wiechert W, Kohlheyer D. Optical control of gene expression in bacteria on the single-cell level by caged compounds. Presented at the Synthetic Biology: Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
    PUB
     
  • [105]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912559
    Sachs CC, Helfrich S, Grünberger A, et al. High-throughput long-term growth characterization of C. glutamicum on single cell using the Mother Machine. Presented at the Colloquium Synthetic Biology - Opportunities for Interdisciplinary Research from Biology to Engineering, Aachen, Germany.
    PUB
     
  • [104]
    2015 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912566
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Single-Cell Bioreactors: Cutting Edge Cultivation Devices for the Ultimate Scale-Down of Bioprocesses. Presented at the DECHEMA-Himmelfahrtstagung "Scale-up and scale-down of bioprocesses", Hamburg-Bergedorf, Germany.
    PUB
     
  • [103]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912605
    Schendzielorz G, Dippong M, Grünberger A, et al. Taking Control over Control: Use of Product Sensing in Single Cells to Remove Flux Control at Key Enzymes in Biosynthesis Pathways. ACS Synthetic Biology. 2014;3(1):21–29.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [102]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912594 OA
    Binder D, Grünberger A, Loeschcke A, et al. Light-responsive control of bacterial gene Expression: precise triggering of the lac promoter activity using photocaged IPTG. Integrative biology. 2014;6(8):755-765.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [101]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912573 OA
    Mustafi N, Grünberger A, Mahr R, et al. Application of a Genetically Encoded Biosensor for Live Cell Imaging of L-Valine Production in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains. PLoS one. 2014;9(1): e85731.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [100]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912589
    Helfrich S, Krämer C, Grünberger A, et al. Microfluids as platform for the spatiotemporal analysis of bacterial populations at single-cell level. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
    PUB
     
  • [99]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912591
    Grünberger A, Probst C, Frunzke J, Noack S, Wiechert W, Kohlheyer D. Microfluidic Single-Cell Cultivation: Opportunity for Industrial Bioprocess Development. Presented at the EMBL Conference – Microfluidics 2014, Heidelberg, Germany.
    PUB
     
  • [98]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912596
    Grünberger A, Probst C, Unthan S, et al. Single-cell cultivation in picoliter scale: Opportunity for bioprocess development. Presented at the 3rd BioProScale Symposium, Berlin, Germany.
    PUB
     
  • [97]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912616
    Unthan S, Grünberger A, van Ooyen J, et al. Beyond growth rate 0.6. What drives Corynebacterium glutamicum to higher growth rates in defined medium. Biotechnology and bioengineering. 2014;111(2):359–371.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [96]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912806
    Binder D, Grünberger A, Loeschcke A, et al. Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
    PUB
     
  • [95]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912730 OA
    Nanda AM, Heyer A, Kramer C, Grünberger A, Kohlheyer D, Frunzke J. Analysis of SOS-Induced Spontaneous Prophage Induction in Corynebacterium glutamicum at the Single-Cell Level. Journal of Bacteriology. 2014;196(1):180-188.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [94]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912766
    Grünberger A. Picoliter Bioreactors. Learning from Single Cells about Large Scale Processes. Presented at the iGEM Meetup, Aachen, Germany.
    PUB
     
  • [93]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912805
    Kohlheyer D, Grünberger A, Weber S, Nedbal L, Wiechert W. Microfluidic Single-Cell Analysis – Potential for Microalgae Research? Presented at the BioSC Workshop | Exploration "Perspectives of Algal Technologies", Jülich, Germany.
    PUB
     
  • [92]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912808
    Mahr R, Mustafi N, Grünberger A, et al. Metabolite biosensors for single cell analysis and the development of production strains. Presented at the 30th Symposium „Mechanisms of gene regulation”, Düsseldorf, Germany.
    PUB
     
  • [91]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912586
    Helfrich S, Azzouzi CE, Krämer C, et al. Microbial Populations on the Microfluidic Analyst's Couch: Approaching Cellular Heterogeneity. Presented at the BioImage Informatics 2014, Leuven, Belgium.
    PUB
     
  • [90]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912588
    Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K. Investigating single-cell growth of microbial cell factories: is counting cells enough? Presented at the 2nd International Workshop on Image-based Systems Biology, Jena (Germany.
    PUB
     
  • [89]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912590
    Mahr R, Mustafi N, Grünberger A, et al. Transcription factor-based biosensor for microbial strain development. Presented at the 30th Symposium "Mechanisms of Gene Regulation" of the VAAM study group "Regulation & Signal Transduction in Prokaryotes", Düsseldorf, Germany.
    PUB
     
  • [88]
    2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912593
    Grünberger A, Unthan S, Mahr R, et al. Systematic screening of single-cell growth and production in a picoliter cultivation platform. Chemie Ingenieur Technik. 2014;86(9):1408.
    PUB | DOI
     
  • [87]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912595
    Kohlheyer D, Grünberger A, Probst C, et al. Single-cell Bioreactors boost Bioprocess Development: New Insights into Cellular Metabolism. Presented at the Metabolic Engineering X, Vancouver, Canada.
    PUB
     
  • [86]
    2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912601
    Grünberger A, Schmitz K, Probst C, Noack S, Wiechert W, Kohlheyer D. Simple microfluidics for complex organisms: A microfluidic chip System for growth and Morphogenesis studies of filamentous fungi. In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2013). Red Hook, NY: Curran; 2014.
    PUB
     
  • [85]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912569
    Binder D, Grünberger A, Loeschcke A, et al. Cage me if you can! Optogenetic bacterial gene regulation using photocaged inducers. Presented at the VAAM Jahrestagung, Dresden, Germany.
    PUB
     
  • [84]
    2014 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912571
    Grünberger A, Probst C, Helfrich S, et al. Microfluidic Single-Cell Analysis Platform for Biotechnological Process Development. In: MicroTAS 2014. San Diego, California: CBM Society; 2014: 3 p.
    PUB
     
  • [83]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912576
    Dusny C, Grünberger A, Wiechert W, Kohlheyer D, Schmid A. From extracellular Environment to functional phenotype. Quantitative comparison of single cell physiology in static and steady environments. Presented at the 3rd BioProScale Symposium "Inhomogeneities in large-scale bioprocesses. System biology and process dynamics", Berlin, Germany.
    PUB
     
  • [82]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912583
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Picoliter Bioreactors. Learning from Single Cells about Large-Scale Bioprocesses. Presented at the 24th Annual conference of the German Society for Cytometry, Dresden, Germany.
    PUB
     
  • [81]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912587
    Mahr R, Mustafi N, Grünberger A, et al. Metabolite biosensors for single cell analysis and the development of production strains. Presented at the Gemeinsame Jahrestagung der Deutschen Gesellschaft für Hygiene und Mikrobiologie und der Vereinigung für Allgemeine und Angewandte Mikrobiologie, Dresden, Germany.
    PUB
     
  • [80]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912575
    Krämer C, Helfrich S, Azzouzi CE, et al. Microfluidics as platform for the spatiotemporal analysis of bacterial populations at single-cell level. Presented at the International Meeting, Phenotypic heterogeneity and sociobiology of bacterial populations, Irsee, Germany.
    PUB
     
  • [79]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912582
    Grünberger A, Probst C, Nanda A, Frunzke J, Wiechert W, Kohlheyer D. Microfluidic Single-Cell Cultivation Systems: Versatile Tools for Microbiology. Presented at the 4th Annual Conference of the Association for General and Applied Microbiology, Dresden, Germany.
    PUB
     
  • [78]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912823
    Mahr R, Mustafi N, Grünberger A, et al. Application of a genetically-encoded metabolite sensor for single cell analysis and development of production strains. Presented at the Metabolic engineering X, Vancouver, Canada.
    PUB
     
  • [77]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912814
    Grünberger A, Probst C. Introduction into Microfluidic Single-Cell Analysis. Presented at the Biology feat, Engineering – SYNBIO – Single Cell Analysis in Microfluidic Devices (Workshop), Jülich, Germany.
    PUB
     
  • [76]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912585
    Sachs CC, Grünberger A, Wiechert W, Nöh K, Kohlheyer D. Robust Automated Image Analysis of Mother Machine Microfluidic Growth Devices. Presented at the BioImage Informatics 2014, Leuven, Belgium.
    PUB
     
  • [75]
    2014 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2912592
    Weber S, Grünberger A, Probst C, Wiechert W, Kohlheyer D. Optimizing growth performance of Corynebacterium glutamicum at the single-cell level. Chemie Ingenieur Technik. 2014;88(9):1414.
    PUB | DOI
     
  • [74]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912597
    Grünberger A, Wiechert W, Kohlheyer D. Single-cell microfluidics: opportunity for bioprocess development. Current opinion in biotechnology. 2014;29:15-23.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [73]
    2014 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912580
    Dusny C, Grünberger A, Rosenthal K, Wiechert W, Schmid A. Quantitative Physiology of Single Cells for Linking Phenotype and Environment. Presented at the 24th Annual Conference of the German Society for Flow Cytometry, Dresden, Germany.
    PUB
     
  • [72]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912599 OA
    Grünberger A, Probst C, Heyer A, Wiechert W, Frunzke J, Kohlheyer D. Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation. Journal of visualized experiments. Bioengineering. 2013;82(82): e50560.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [71]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912606
    Hoffmann K, Grünberger A, Lausberg F, Bott M, Eggeling L. Visualization of Imbalances in Sulfur Assimilation and Synthesis of Sulfur-Containing Amino Acids at the Single-Cell Level. Applied and environmental microbiology. 2013;79(21):6730-6736.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [70]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912604
    Mahr R, Mustafi N, Grünberger A, et al. Application of a genetically encoded biosensor for single cell analysis and strain development of production strains. Presented at the New concepts and approaches in microbiology, Heidelberg, Germany.
    PUB
     
  • [69]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912609
    Nanda A, Heyer A, Grünberger A, et al. Single-cell Dynamics of the SOS Response in Corynebacterium glutamicum. Presented at the Bacterial Networks, Pultusk, Poland.
    PUB
     
  • [68]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912611 OA
    Probst C, Grünberger A, Wiechert W, Kohlheyer D. Polydimethylsiloxane (PDMS) Sub-Micron Traps for Single-Cell Analysis of Bacteria. Micromachines. 2013;4(4):357-369.
    PUB | PDF | DOI | WoS
     
  • [67]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912623
    Heyer A, Nanda A, Grünberger A, Kohlheyer D, Frunzke J. Spontaneous prophage induction in Corynebacterium glutamicum. Presented at the VAAM-Tagung 2013, Bremen, Germany.
    PUB
     
  • [66]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912630
    Kohlheyer D, Grünberger A, Probst C, et al. Microbial single cell analysis of production strains in microfabricated habitats. Presented at the DECHEMA-Workshop Microfluidics for Systems Biology and Bioprocess Development, Frankfurt, Germany.
    PUB
     
  • [65]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912825
    Binder D, Grünberger A, Loeschcke A, et al. Characterization of light-triggered gene expression in E. coli with respect to population and single cell response. Presented at the Jülich Biotech Day, Jülich, Germany.
    PUB
     
  • [64]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912745
    Grünberger A, Lai P-K, Blanco MA, Roberts CJ. Coarse-Grained Modeling of Protein Second Osmotic Virial Coefficients: Sterics and Short-Ranged Attractions. The Journal of Physical Chemistry B. 2013;117(3):763-770.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [63]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912810
    Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K. Analysis of microbial observables on single cell level: Challenges of Cell Clusters for Microscopy-based Image Processing. Presented at the 9th European Congress of Chemical Engineering (ECCE9)/ 2nd European Congress of Applied Biotechnology (ECAB2), The Hague, Netherlands.
    PUB
     
  • [62]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912824
    Nanda AM, Heyer A, Grünberger A, et al. Single-cell dynamics of the SOS response in Corynebacterium glutamicum. Presented at the Jülich Biotech Day, Jülich, Germany.
    PUB
     
  • [61]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912827
    Mahr R, Mustafi N, Grünberger A, et al. Application of a genetically- encoded metabolite sensor for single cell analysis and the development of production strains. Presented at the Jülich Biotech Day, Jülich, Germany.
    PUB
     
  • [60]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912829
    Sachs C, Grünberger A, Probst C, Wiechert W, Kohlheyer D. Automated image analysis pipeline for single cell bacterial growth studies. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
    PUB
     
  • [59]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912834
    Binder D, Grünberger A, Loeschcke A, et al. Characterization of light-triggered gene expression in E. coli with respect to population and single cell response. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
    PUB
     
  • [58]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912836
    Binder D, Grünberger A, Loeschcke A, et al. Characterization of light-triggered gene expression in E. coli with respect to population and single cell response. Presented at the New Approaches and Concepts in Microbiology, Heidelberg, Germany.
    PUB
     
  • [57]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912603
    Grünberger A, Probst C, Unthan S, et al. Single Cell Bioreactors for Bioprocess Optimization. Presented at the Jülich Biotech Day 2013, Jülich,Germany.
    PUB
     
  • [56]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912608
    Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J. SOS-induced spontaneous prophage induction in Corynebacterium glutamicum. Presented at the Jülich Biotech Day 2013, Jülich, Germany.
    PUB
     
  • [55]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912613
    Probst C, Grünberger A, Frunzke J, Wiechert W, Kohlheyer D. Microfluidic cultivation technology and application: analysing single-microbes under perfect environmental control. Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
    PUB
     
  • [54]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912615
    Helfrich S, Azzouzi CE, Grünberger A, Wiechert W, Nöh K. Explorative Analysis of Cell Population Development: Customizable Interactive Lineage Trees. Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
    PUB
     
  • [53]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912618
    Kohlheyer D, Grünberger A, Probst C, Frunzke J, Wiechert W. Picoliter fermentation with single bacteria: Learning from the one to unravel the crowd. Presented at the 2nd International Congress Implementation of Microreactor Technology in Biotechnology, Cavtat, Croatia.
    PUB
     
  • [52]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912620
    Noack S, Grünberger A, van Ooyen J, Kohlheyer D, Wiechert W. Increasing biomass productivity of C. glutamicum - new insights from microscale cultivations. Presented at the 9th European Congress of Chemical Engineering, Den Haag, The Netherlands.
    PUB
     
  • [51]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912622
    Wiechert W, Kohlheyer D, Noack S, Frunzke J, Mustafi N, Grünberger A. Picoliter Bioreactors. Learning from Single Cells about Large Scale Processes. Presented at the Copenhagen Bioscience Conferences, Cell Factories and Biosustainability, Favrholm, Denmark.
    PUB
     
  • [50]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912625
    Heinrich J, Grünberger A, Probst C, Wiechert W, Kohlheyer D. Single cell growth under constant environmental conditions and defined C sources: A case study for Corynebacterium glutamicum. Presented at the VAAM-Tagung 2013, Bremen, Germany.
    PUB
     
  • [49]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912627
    Probst C, Frank P, Grünberger A, Wiechert W, Kohlheyer D. Time lapse microbial single cell analysis in a micro fabricated batch reactor. Presented at the Single Cell Analysis Europe 2013, Barcelona, Spain.
    PUB
     
  • [48]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2614036
    Baumgart M, Unthan S, Rückert C, et al. Construction of a prophage-free variant of Corynebacterium glutamicum ATCC 13032 - a platform strain for basic research and industrial biotechnology. Applied and environmental microbiology. 2013;79(19):6006-6015.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [47]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912602
    Grünberger A, Helfrich S, Mustafi N, et al. Automated High-Throughput Time-Lapse Microscopy of Bacteria Microcolonies in Parallelized Monolayer Growth Chambers. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications, Jülich, Germany.
    PUB
     
  • [46]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912607
    Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J. SOS-induced spontaneous prophage induction in Corynebacterium glutamicum. Presented at the Nikon Symposium on Advanced Imaging in Cell- and Microbiology Technology and Applications, Jülich, Germany.
    PUB
     
  • [45]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912614
    Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D. Continuous Non-Invasive Real-Time Viability Measurement of Bacteria on Single Cell Level in Microfluidic Chip Cultures. Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
    PUB
     
  • [44]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912619
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Femtoliter chemostat for long-term bacteria growth and production analysis on single cell level. Presented at the 2nd International Conference Implementation of Microreactor Technology in Biotechnology, Cavtat, Croatia.
    PUB
     
  • [43]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912621
    Grünberger A, Mustafi N, Probst C, Frunzke J, Wiechert W, Kohlheyer D. Towards High-Throughput Microbial Single Cell Analysis In Picoliter Bioreactors. Presented at the 9th European Congress of Chemical Engineering, Den Haag, The Netherlands.
    PUB
     
  • [42]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912626
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Femtoliter chemostat for long-term bacteria growth and production analysis on single cell level. Presented at the Single Cell Analysis Europe 2013, Barcelona, Spain.
    PUB
     
  • [41]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912809
    Frunzke J, Mahr R, Grünberger A, Mustafi N, Kohlheyer D. Microbial Metabolite Production – Live in Concert. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
    PUB
     
  • [40]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912828
    Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D. Continuous Non-Invasive Real-Time Viability Measurement of Bacteria on Single Cell Level in Microfluidic Chip Cultures? Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
    PUB
     
  • [39]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912830
    Probst C, Grünberger A, Krämer C, Wiechert W, Kohlheyer D. Microfluidic single-cell analysis in dynamic environments. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
    PUB
     
  • [38]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912835
    Mahr R, Mustafi N, Grünberger A, et al. Application of a genetically- encoded metabolite sensor for single cell analysis and the development of production strains. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
    PUB
     
  • [37]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912826
    Helfrich S, Azzouzi CE, Grünberger A, Wiechert W, Nöh K. Exploration and Analysis of cell population development. Customizable interactive lineage trees. Presented at the Jülich Biotech Day, Jülich, Germany.
    PUB
     
  • [36]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912833
    Nanda AM, Heyer A, Grünberger A, et al. Single-cell dynamics of the SOS response in Corynebacterium glutamicum. Presented at the Advanced Imaging in Cell- and Microbiology: Technology and Applications (AICMB), Jülich, Germany.
    PUB
     
  • [35]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912600
    Probst C, Grünberger A, Wiechert W, Kohlheyer D. Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes. Journal of microbiological methods. 2013;95(3):470-476.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [34]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912612
    Nanda A, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J. SOS-induced spontaneous prophage induction in Corynebacterium glutamicum. Presented at the EMBL Heidelberg "New Approaches and Concepts in Microbiology", Heidelberg, Germany.
    PUB
     
  • [33]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912617
    Krämer C, Grünberger A, Probst C, Wiechert W, Kohlheyer D. Continuous viability fluorescent staining of growing Corynebacterium glutamicum colonies without sample preparation in an automated microfluidic measurement system. Presented at the How Deas Is Dead III Conference, Berlin, Germany.
    PUB
     
  • [32]
    2013 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912624
    Grünberger A, Mustafi N, Probst C, Frunzke J, Wiechert W, Kohlheyer D. High-throughput Microbial Single Cell analysis in Picoliter Bioreactors. Presented at the VAAM-Tagung 2013, Bremen, Germany.
    PUB
     
  • [31]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912631
    Grünberger A, van Ooyen J, Paczia N, et al. Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments. Biotechnology and bioengineering. 2013;110(1):220-228.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [30]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912747
    Scholz KE, Okrob D, Kopka B, et al. Synthesis of Chiral Cyanohydrins by Recombinant Escherichia coli Cells in a Micro-Aqueous Reaction System. Applied and Environmental Microbiology. 2012;78(14):5025-5027.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [29]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912635
    Binder S, Schendzielorz G, Kohlheyer D, et al. Metabolite sensors for single-cell isolation of producing bacteria. Presented at the Metabolic Engineering IX, Biarritz, France.
    PUB
     
  • [28]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912642
    Grünberger A, Frank P, Probst C, Wiechert W, Kohlheyer D. Single Cell Microfluidics: From Fabrication to Application. Presented at the Jülich Biotech Day, Jülich, Germany.
    PUB
     
  • [27]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912647
    Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K. Semi-Automated Evaluation of Microbial Observables from High-Throughput Time-lapse Microscopy. Presented at the German Conference on Bioinformatics 2012, Jena (Germany).
    PUB
     
  • [26]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912767
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Fermentation at Picoliter Scale: Microfluidics for single cell analysis of prokaryotic production strains. Presented at the Achema 2012, Frankfurt, Germany.
    PUB
     
  • [25]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912837
    Probst C, Grünberger A, Wiechert W, Kohlheyer D. Screening of Escherichia coli on single-cell level by hyphenating microfluidic picoliter fermentation and optical tweezers. Presented at the 3rd European Conference on Microfluidics, Heidelberg, Germany.
    PUB
     
  • [24]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912728 OA
    Grünberger A, Paczia N, Probst C, et al. A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level. Lab on a Chip. 2012;12(11):2060-2068.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [23]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912776
    Grünberger A, Probst. C, Frank P, Wiechert W, Kohlheyer D. Single Cell Analysis of Industrially Relevant Bacterial Strains in Picoliter Environments. Presented at the EMBL Conference – Microfluidics 2012, Heidelberg, Germany.
    PUB
     
  • [22]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912839
    Probst C, Grünberger A, Wiechert W, Kohlheyer D. Phenotypic Sorting and Analysis of Bacteria Production Strains using Optical Tweezers and Microfluidics. Presented at the EMBL Conference – Microfluidics 2012, Heidelberg, Germany.
    PUB
     
  • [21]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912841
    Nanda AM, Grünberger A, Heyer A, et al. Dynamics of the SOS response in single cells of Corynebacterium glutamicum. Presented at the 2nd Molecular Microbiology Meeting Würzburg, Würzburg, Germany.
    PUB
     
  • [20]
    2012 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912639
    Probst C, Grünberger A, Kohlheyer D, Wiechert W. Phenotypic Sorting and Analysis of Bacteria ProductionStrains Using Optical Tweezers and Microfluidics. Chemie - Ingenieur - Technik: CIT. 2012;84(8):1344.
    PUB | DOI
     
  • [19]
    2012 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912641
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Femtoliter Growth Channels. Bacteria Long-Term Growth Patterns Analysis on Singel Cell Level. Chemie - Ingenieur - Technik (CIT). 2012;84(8):1407.
    PUB | DOI
     
  • [18]
    2012 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912646
    Grünberger A, Helfrich S, Probst C, Nöh K, Wiechert W, Kohlheyer D. Industrial Biotechnology meets Microfluidics - Disposable high-throughput single cell analysis device for industrially relevant bacterial strains. In: Colin S, ed. Proceedings - µFLU-12. Publications S.H.F. Paris: SHF; 2012.
    PUB
     
  • [17]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912633
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Picoliter bioreactors for growth heterogeneity studies of industrially relevant bacteria on single cell level. Presented at the 2nd BioProScale Symposium: Inhomogeneities in large-scale bioprocesses: System biology and process dynamics, Berlin, Germany.
    PUB
     
  • [16]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912638
    Mustafi N, Grünberger A, Helfrich S, et al. A biosensor for the intracellular detection of L-methionine and branched-chain amino acids - Monitoring of amino acid production at the single cell level. Presented at the 15th International Conference on Biotechnology, Istanbul, Turkey.
    PUB
     
  • [15]
    2012 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912640
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. High-Throughput Growth Rate Determination of Bacteria Micro colonies on Single Cell Level. Chemie - Ingenieur - Technik: CIT. 2012;84(8):1336-1337.
    PUB | DOI
     
  • [14]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912645
    Kohlheyer D, Grünberger A, Probst C, Frank P, Wiechert W. Catch it and batch it: picoliter fermentation at the single cell level. Presented at the International Workshop on New and Synthetic Bioproduction Systems, Hamburg-Harburg, Germany.
    PUB
     
  • [13]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2912746
    Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J. The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids. Metabolic Engineering. 2012;14(4):449-457.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [12]
    2012 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912758
    Grünberger A, Probst C, Binder S, et al. Single Cell Trapping and Analysis for Prokaryotic Production Strains in Sub-µm Fluidic Structures. In: Landers J, ed. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011 (MiroTAS 2011). Red Hook, NY: Curran; 2012.
    PUB
     
  • [11]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912777
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Towards high-throughput single cell growth optimization and production analysis using picoliter bioreactors. Presented at the Metabolic Engineering IX 2012, Biarritz, France.
    PUB
     
  • [10]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912838
    Frank P, Probst C, Grünberger A, Wiechert W, Kohlheyer D. “Catch it and Batch it”- Microfluidics single cell batch cultivation utilizing picoliter bioreactors. Presented at the ProcessNet- Jahrestagung 2012 und 30. DECHEMA Jahrestagung der Biotechnologen, Karlsruhe, Germany.
    PUB
     
  • [9]
    2012 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912840
    Nanda AM, Grünberger A, Heyer A, et al. Dynamics of the SOS response in single cells of Corynebacterium glutamicum. Presented at the Microbial Stress: from Molecules to System, Belgirate (VB)/Maggiore Lake, Italy.
    PUB
     
  • [8]
    2012 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2912643
    Grünberger A, Helfrich S, Probst C, Wiechert W, Nöh K, Kohlheyer D. High-Throughput lineage tree investigations of bacteria microcolonies using arrays of monolayer growth chambers. In: Proceedings of The Sixteenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2012). San Diego, California: CBMS; 2012.
    PUB
     
  • [7]
    2011 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912778
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. Single Cell Trapping and Analysis for Prokaryotic Production Strains in Sub -µm Fluidic Structures. Presented at the NanoBioTech-Montreux 2011, Montreux, Switzerland.
    PUB
     
  • [6]
    2011 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912843
    Scholz KE, Okrob D, Kopka B, et al. Fluorescence reporters for the analysis of whole cell biocatalysts in non-conventional media. Presented at the Biotrans 2011, Giardini Naxos (Messina), Italy.
    PUB
     
  • [5]
    2011 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912811
    Kohlheyer D, Grünberger A, Probst C, Wiechert W. Sub-µm Fluidic Structures for Single Cell Trapping and Analysis of Prokaryotic Production Strains. Presented at the 21st Annual conference of the German Society for Cytometry, Bonn, Germany.
    PUB
     
  • [4]
    2011 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912842
    Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J. A biosensor for the intracellular detection of L-methionine and branched-chain amino acids. Presented at the 5th International Conference on Analysis of Microbial Cells at the Single Cell Level, Caryy-Le-Rouet, France.
    PUB
     
  • [3]
    2011 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912768
    Grünberger A, Probst C, Wiechert W, Kohlheyer D. A continuous picoliter bioreactor for heterogeneity studies of bacteria microcolonies. Presented at the NanoBioTech-Montreux 2011, Montreux, Switzerland.
    PUB
     
  • [2]
    2010 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912812
    Blanko MA, Grünberger A, Sahin E, Roberts CJ. Protein Interactions from Kirwood-Buff Analysis of Light Scattering and Coarse-Grained Molecular Models. Presented at the AIChE Annual Meeting, Salt Lake City (UT), USA.
    PUB
     
  • [1]
    2009 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2912813
    Grünberger A, Stephens E, Hankamer B. Media optimization for the microalgae Chamydomonas reinhardtii Stm6 using statistical design. Presented at the IMB Summer Symposium: A systems Biology approach to biofuel production: From light capture to biodiesel production, Brisbane, Australia.
    PUB
     

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