61 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2984305Besse, Caroline, Niemann, Hartmut, and Sewald, Norbert. 2023. “Increasing the stability of flavin-dependent halogenases by disulfide engineering”. ChemBioChem: e202300700.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2966452Schnepel, Christian, Moritzer, Ann-Christin, Gäfe, Simon, Montua, Nicolai, Minges, Hannah, Nieß, Anke, Niemann, Hartmut, and Sewald, Norbert. 2023. “Enzymatic Late-Stage Halogenation of Peptides”. Chembiochem : a European journal of chemical biology 24 (1): e202200569.
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2023 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2980726Gäfe, Simon, and Niemann, Hartmut. 2023. “Structural basis of regioselective tryptophan dibromination by the single-component flavin-dependent halogenase AetF”. Acta Crystallographica Section D : Structural Biology 79 (Pt 7): 596-609.
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981627Alexander, Leila T, Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A, Bayo, Yusupha, Bhabha, Gira, Breyton, Cecile, et al. 2023. “Protein target highlights in CASP15: Analysis of models by structure providers”. Proteins: Structure, Function, and Bioinformatics .
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2979520Gilzer, Dominic, Kowal, Julia, Flottmann, Franziska, and Niemann, Hartmut. 2023. “The type III secretion chaperone SctY may shield the hydrophobic export gate-binding C-terminus of its substrate SctX”. Acta Crystallographica Section D : Structural Biology D79 (6): 508-517.
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2969061Hansen, Philipp, Haubenthal, Thomas, Reiter, Caroline, Kniewel, Jana, Bosse-Plois, Karla, Niemann, Hartmut, von Bargen, Kristine, and Haas, Albert. 2023. “Differential Effects of Rhodococcus equi Virulence-Associated Proteins on Macrophages and Artificial Lipid Membranes”. Microbiology Spectrum : e0341722.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2961733Geerds, Christina, Bleymüller, Willem M, Meyer, Timo, Widmann, Christiane, and Niemann, Hartmut. 2022. “A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat”. Acta Crystallographica Section D : Structural Biology 78 ( 3): 310-320.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2966836Gilzer, Dominic, Baum, Eileen, Lieske, Nele, Kowal, Julia, and Niemann, Hartmut. 2022. “Crystals of SctV from different species reveal variable symmetry for the cytosolic domain of the type III secretion system export gate”. Acta Crystallographica Section F : Structural Biology Communications 78 (11): 386-394.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2963687Gilzer, Dominic, Schreiner, Madeleine, and Niemann, Hartmut. 2022. “Direct interaction of a chaperone-bound type III secretion substrate with the export gate”. Nature Communications 13 (1): 2858.
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2021 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2954748Dachwitz, Steffen, Widmann, Christiane, Frese, Marcel, Niemann, Hartmut, and Sewald, Norbert. 2021. “Enzymatic halogenation: enzyme mining, mechanisms, and implementation in reaction cascades”. In Amino Acids, Peptides and Proteins. Volume 44, ed. Maxim Ryadnov and Ferenc Hudecz, 1-43. Amino Acids, Peptides And Proteins. Cambridge: Royal Society of Chemistry.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2956908Geerds, Christina, Haas, Albert, and Niemann, Hartmut. 2021. “Conformational changes of loops highlight a potential binding site in Rhodococcus equi VapB”. Acta crystallographica. Section F: Structural biology communications 77 (Pt 8): 246-253.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2950229Moritzer, Ann-Christin, Prior, Tina, and Niemann, Hartmut. 2020. “Not Cleaving the His-tag of Thal Results in More Tightly Packed and Better-Diffracting Crystals”. Crystals 10 (12): 1135.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945148Meyer, Timo, Zumbrägel, Nadine, Geerds, Christina, Gröger, Harald, and Niemann, Hartmut. 2020. “Structural Characterization of an S-enantioselective Imine Reductase from Mycobacterium Smegmatis”. Biomolecules 10 (8): 1130.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944738Widmann, Christiane, Ismail, Mohamed, Sewald, Norbert, and Niemann, Hartmut. 2020. “Structure of apo flavin-dependent halogenase Xcc4156 hints at a reason for cofactor-soaking difficulties”. Acta Crystallographica Section D Structural Biology 76 (7): 687-697.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934121Moritzer, Ann-Christin, Minges, Hannah, Prior, Tina, Frese, Marcel, Sewald, Norbert, and Niemann, Hartmut. 2019. “Structure-based switch of regioselectivity in the flavin-dependent tryptophan 6-halogenase Thal”. Journal of Biological Chemistry 294 (7): 2529-2542.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2937628Lüdel, Frank, Bufe, Sandra, Bleymüller, Willem M., de Jonge, Hugo de, Iamele, Luisa, Niemann, Hartmut, and Hellweg, Thomas. 2019. “Distinguishing Between Monomeric scFv and Diabody in Solution Using Light and Small Angle X-ray Scattering”. Antibodies 8 (4): 48.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2934796Andres, Fabio, Iamele, Luisa, Meyer, Timo, Stuber, Jakob C, Kast, Florian, Gherardi, Ermanno, Niemann, Hartmut, and Pluckthun, Andreas. 2019. “Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.”. Journal of molecular biology 431 (10): 2020-2039.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2939444Dietz, Marina S., Wehrheim, S. Sophia, Harwardt, Marie-Lena I. E., Niemann, Hartmut, and Heilemann, Mike. 2019. “Competitive Binding Study Revealing the Influence of Fluorophore Labels on Biomolecular Interactions”. NANO LETTERS 19 (11): 8245-8249.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2936258Buß, Maren, Tegtmeyer, Nicole, Schnieder, Jennifer, Dong, Xianchi, Li, Jing, Springer, Timothy A, Backert, Steffen, and Niemann, Hartmut. 2019. “Specific high affinity interaction of Helicobacterpylori CagL with integrin alphaV beta6 promotes type IV secretion of CagA into human cells.”. The FEBS journal 286 (20): 3980-3997.
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2019 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2934621Dietz, Marina S., Harwardt, Marie-Lena I. E., Wohland, Thorsten, Niemann, Hartmut, and Heilemann, Mike. 2019. “Met Receptor Tyrosine Kinase Activation Studied at the Single-Molecule Level”. In BIOPHYSICAL JOURNAL, 116:232A. Cambridge: Cell Press.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2919984Neubauer, Pia, Widmann, Christiane, Wibberg, Daniel, Schröder, Lea, Frese, Marcel, Kottke, Tilman, Kalinowski, Jörn, Niemann, Hartmut, and Sewald, Norbert. 2018. “A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination”. PLoS ONE 13 (5): e0196797.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920494Buß, Maren, Geerds, Christina, Patschkowski, Thomas, Niehaus, Karsten, and Niemann, Hartmut. 2018. “Perfect merohedral twinning combined with noncrystallographic symmetry potentially causes the failure of molecular replacement with low-homology search models for the flavin-dependent halogenase HalX from Xanthomonas campestris”. Acta Crystallographica Section F Structural Biology Communications 74 (6): 345-350.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2914444Harwardt, Maria-Lena I.E., Young, Phoebe, Bleymüller, Willem, Meyer, Timo, Karathanasis, Christos, Niemann, Hartmut, Heilemann, Mike, and Dietz, Marina S. 2017. “Membrane dynamics of resting and internalin B-bound MET receptor tyrosine kinase studied by single-molecule tracking”. FEBS Open Bio 7 (9): 1422-1440.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907323Bleymüller, Willem, Lämmermann, Nina, Ebbes, Maria, Maynard, Daniel, Geerds, Christina, and Niemann, Hartmut. 2016. “MET-activating Residues in the B-repeat of theListeria monocytogenesInvasion Protein InlB”. Journal of Biological Chemistry 291 (49): 25567-25577.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2905854Schreiner, Madeleine, Schlesinger, Ramona, Heberle, Joachim, and Niemann, Hartmut. 2016. “Crystal structure of Halobacterium salinarum halorhodopsin with a partially depopulated primary chloride-binding site.”. Acta crystallographica. Section F, Structural biology communications 72 (9): 692-699.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904685Koschut, David, Richert, Ludovic, Pace, Giuseppina, Niemann, Hartmut, Mely, Yves, and Orian-Rousseau, Veronique. 2016. “Live cell imaging shows hepatocyte growth factor-induced Met dimerization”. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1863 (7): 1552-1558.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2769481Volz, Yvonne, Koschut, David, Matzke-Ogi, Alexandra, Dietz, Marina S., Karathanasis, Christos, Richert, Ludovic, Wagner, Moritz G., et al. 2015. “Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6”. Bioscience Reports 35 (4): e00236.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2723568Barden, Stephan, and Niemann, Hartmut. 2015. “Adhesion of Several Cell Lines to Helicobacter pylori CagL Is Mediated by Integrin αVβ6 via an RGDLXXL Motif”. Journal of Molecular Biology 427 (6 Pt B): 1304-1315.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2757969Schreiner, Madeleine, Schlesinger, Ramona, Heberle, Joachim, and Niemann, Hartmut. 2015. “Structure of Halorhodopsin from Halobacterium salinarum in a new crystal form that imposes little restraint on the E-F loop”. Journal of Structural Biology 190 (3): 373-378.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2685751Geerds, Christina, Wohlmann, Jens, Haas, Albert, and Niemann, Hartmut. 2014. “Structure of Rhodococcus equi virulence-associated protein B (VapB) reveals an eight-stranded antiparallel β-barrel consisting of two Greek-key motifs”. Acta crystallographica. Section F, Structural biology communications 70 (Pt 7): 866-871.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2673656Dietz, Marina S., Fricke, Franziska, Krueger, Carmen L., Niemann, Hartmut, and Heilemann, Mike. 2014. “Receptor-Ligand Interactions: Binding Affinities Studied by Single-Molecule and Super-Resolution Microscopy on Intact Cells”. ChemPhysChem 15 (4): 671-676.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2673048Kolditz, F., Krausze, J., Heinz, D. W., Niemann, Hartmut, and Müller-Goymann, C. C. 2014. “Wound healing potential of a dimeric InlB variant analyzed by in vitro experiments on re-epithelialization of human skin models”. European journal of pharmaceutics and biopharmaceutics 86 (2: Theme Issue: Dermal and Transdermal Drug Delivery): 277-283.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2676579Barden, Stephan, Schomburg, Benjamin, Conradi, Jens, Backert, Steffen, Sewald, Norbert, and Niemann, Hartmut. 2014. “Structure of a three-dimensional domain-swapped dimer of the Helicobacter pylori type IV secretion system pilus protein CagL”. Acta crystallographica. Section D, Biological crystallography 70 (Pt 5): 1391-1400.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2607024Dietz, Marina S., Haße, Daniel, Ferraris, Davide M., Göhler, Antonia, Niemann, Hartmut, and Heilemann, Mike. 2013. “Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells”. BMC biophysics 6 (1): 6.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2635833Niemann, Hartmut. 2013. “Structural basis of MET receptor dimerization by the bacterial invasion protein InlB and the HGF/SF splice variant NK1”. Biochimica Et Biophysica Acta (Bba) - Proteins & Proteomics 1834 (10): 2195-2204.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2637151Barden, Stephan, Lange, Stefanie, Tegtmeyer, Nicole, Conradi, Jens, Sewald, Norbert, Backert, Steffen, and Niemann, Hartmut. 2013. “A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL”. Structure (London, England : 1993) 21 (11): 1931-1941.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2520078Schreiner, Madeleine, and Niemann, Hartmut. 2012. “Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD”. BMC Structural Biology 12 (1): 13.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2529531Niemann, Hartmut, Gherardi, Ermanno, Bleymüller, Willem, and Heinz, Dirk W. 2012. “Engineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex”. Protein Science 21 (10): 1528-1539.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2352218Niemann, Hartmut. 2011. “Structural insights into Met receptor activation”. European Journal of Cell Biology 90 (11): 972-981.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2093288Ebbes, Maria, Bleymüller, Willem, Cernescu, Mihaela, Noelker, Rolf, Brutschy, Bernd, and Niemann, Hartmut. 2011. “Fold and Function of the InlB B-repeat”. Journal of Biological Chemistry 286 (17): 15496-15506.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2317316Thoms, Sven, Hofhuis, Julia, Thöing, Christian, Gartner, Jutta, and Niemann, Hartmut. 2011. “The unusual extended C-terminal helix of the peroxisomal alpha/beta-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization”. Journal of Structural Biology 175 (3): 362-371.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1796416Lutz, Jens, Brabeck, Christine, Niemann, Hartmut, Kloz, Ulrich, Korth, Carsten, Lingappa, Vishwanath R., and Buerkle, Alexander. 2010. “Microdeletions within the hydrophobic core region of cellular prion protein alter its topology and metabolism”. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 393 (3): 439-444.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1588661Ferraris, Davide M., Gherardi, Ermanno, Di, Ying, Heinz, Dirk W., and Niemann, Hartmut. 2010. “Ligand-Mediated Dimerization of the Met Receptor Tyrosine Kinase by the Bacterial Invasion Protein InlB”. JOURNAL OF MOLECULAR BIOLOGY 395 (3): 522-532.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2444105Jung, C., Matzke, A., Niemann, Hartmut, Schwerk, Christian, Tenenbaum, Tobias, and Orian-Rousseau, V. 2009. “Involvement of CD44v6 in InlB-dependent Listeria invasion”. Molecular Microbiology 72 (5): 1196-1207.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592639Buttner, Carina R., Sorg, Isabel, Cornelis, Guy R., Heinz, Dirk W., and Niemann, Hartmut. 2008. “Structure of the Yersinia enterocolitica type III secretion translocator chaperone SycD”. JOURNAL OF MOLECULAR BIOLOGY 375 (4): 997-1012.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592014Niemann, Hartmut, Petoukhov, Maxim V., Hartlein, Michael, Moulin, Martine, Gherardi, Ermanno, Timmins, Peter, Heinz, Dirk W., and Svergun, Dmitri I. 2008. “X-ray and neutron small-angle scattering analysis of the complex formed by the met receptor and the Listeria monocytogenes invasion protein InlB”. JOURNAL OF MOLECULAR BIOLOGY 377 (2): 489-500.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927887Baumann, F., Tolnay, M., Brabeck, C., Pahnke, J., Kloz, U., Niemann, Hartmut, Heikenwalder, M., Rulicke, T., Burkle, A., and Aguzzi, A. 2007. “Lethal recessive myelin toxicity of prion protein lacking its central domain”. EMBO J 26 (2): 538-547.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927861Niemann, Hartmut, Jager, V., Butler, P. J., van den Heuvel, J., Schmidt, S., Ferraris, D., Gherardi, E., and Heinz, D. W. 2007. “Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB”. Cell 130 (2): 235-246.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927872Bosse, T., Ehinger, J., Czuchra, A., Benesch, S., Steffen, A., Wu, X., Schloen, K., et al. 2007. “Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways”. Mol Cell Biol 27 (19): 6615-6628.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927900Niemann, Hartmut, Schmoldt, H. U., Wentzel, A., Kolmar, H., and Heinz, D. W. 2006. “Barnase fusion as a tool to determine the crystal structure of the small disulfide-rich protein McoEeTI”. J Mol Biol 356 (1): 1-8.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927908Buttner, C. R., Cornelis, G. R., Heinz, D. W., and Niemann, Hartmut. 2005. “Crystal structure of Yersinia enterocolitica type III secretion chaperone SycT”. Protein Sci 14 (8): 1993-2002.
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927915Niemann, Hartmut, Schubert, W. D., and Heinz, D. W. 2004. “Adhesins and invasins of pathogenic bacteria: a structural view”. Microbes Infect 6 (1): 101-112.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927921Machner, M. P., Frese, S., Schubert, W. D., Orian-Rousseau, V., Gherardi, E., Wehland, J., Niemann, Hartmut, and Heinz, D. W. 2003. “Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes”. Mol Microbiol 48 (6): 1525-1536.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927932Klockow, B., Tichelaar, W., Madden, D. R., Niemann, Hartmut, Akiba, T., Hirose, K., and Manstein, D. J. 2002. “The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes”. EMBO J 21 (3): 240-250.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927942Niemann, Hartmut, Knetsch, M. L., Scherer, A., Manstein, D. J., and Kull, F. J. 2001. “Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms”. EMBO J 20 (21): 5813-5821.
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927950Dietzel, S., Niemann, Hartmut, Bruckner, B., Maurange, C., and Paro, R. 1999. “The nuclear distribution of Polycomb during Drosophila melanogaster development shown with a GFP fusion protein”. Chromosoma 108 (2): 83-94.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927957Ramirez-Alvarado, M., Blanco, F. J., Niemann, Hartmut, and Serrano, L. 1997. “Role of beta-turn residues in beta-hairpin formation and stability in designed peptides”. J Mol Biol 273 (4): 898-912.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1927964Maercker, C., Harjes, P., Neben, M., Niemann, Hartmut, Sianidis, G., and Lipps, H. J. 1997. “The formation of new nucleoli during macronuclear development of the hypotrichous ciliate Stylonychia lemnae visualized by in situ hybridization”. Chromosome Res 5 (5): 333-335.