40 Publikationen
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949613Bakonyi, D., Toelzer, C., Stricker, M., Hummel, W., Niefind, K., Gröger, H.: Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile. Catalysts. 10, : 1281 (2020).PUB | PDF | DOI | WoS
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916563Bakonyi, D., Hummel, W.: Cloning, expression, and biochemical characterization of a novel NADP(+)-dependent 7 alpha-hydroxysteroid dehydrogenase from Clostridium difficile and its application for the oxidation of bile acids. ENZYME AND MICROBIAL TECHNOLOGY. 99, 16-24 (2017).PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909081Rulli, G., Duangdee, N., Hummel, W., Berkessel, A., Gröger, H.: First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2017, 812-817 (2017).PUB | DOI | WoS
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909084Biermann, M., Bakonyi, D., Hummel, W., Gröger, H.: Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants. GREEN CHEMISTRY. 19, 405-410 (2017).PUB | DOI | WoS
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904890Bulut, D., Duangdee, N., Gröger, H., Berkessel, A., Hummel, W.: Screening, Molecular Cloning, and Biochemical Characterization of an Alcohol Dehydrogenase from Pichia pastoris Useful for the Kinetic Resolution of a Racemic β-Hydroxy-β-trifluoromethyl Ketone. Chembiochem. 17, 1349-1358 (2016).PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2764353Metzner, R., Hummel, W., Wetterich, F., Koenig, B., Gröger, H.: Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block. Organic Process Research & Development. 19, 635-638 (2015).PUB | DOI | WoS
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2721884Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., Liese, A., Herz, H.-G., Bornscheuer, U.T.: An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers. Angewandte Chemie (International ed. in English). 54, 2784-2787 (2015).PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729781Sato, H., Hummel, W., Gröger, H.: Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Media. Angewandte Chemie (International ed. in English). 54, 4488-4492 (2015).PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2759821Engels, L., Henze, M., Hummel, W., Elling, L.: Enzyme Module Systems for the Synthesis of Uridine 5 '-Diphospho-alpha-D-glucuronic Acid and Non-Sulfated Human Natural Killer Cell-1 (HNK-1) Epitope. Advanced Synthesis & Catalysis. 357, 1751-1762 (2015).PUB | DOI | WoS
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2761249Bulut, D., Gröger, H., Hummel, W.: Development of a growth-dependent selection system for identification of L-threonine aldolases. Applied Microbiology and Biotechnology. 99, 5875-5883 (2015).PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729792Heidlindemann, M., Hammel, M., Scheffler, U., Mahrwald, R., Hummel, W., Berkessel, A., Gröger, H.: Chemoenzymatic Synthesis of Vitamin B5-Intermediate (R)-Pantolactone via Combined Asymmetric Organo- and Biocatalysis. The Journal of Organic Chemistry. 80, 3387-3396 (2015).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2677387Winkler, T., Gröger, H., Hummel, W.: Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from a, b- Unsaturated Aldehydes. ChemCatChem. 6, 961-964 (2014).PUB | DOI | WoS
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708863Müller, C.A., Dennig, A., Welters, T., Winkler, T., Ruff, A.J., Hummel, W., Gröger, H., Schwaneberg, U.: Whole-cell double oxidation of n-heptane. Journal of biotechnology. 191, 196-204 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708851Hummel, W., Gröger, H.: Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems. Journal of biotechnology. 191, 22-31 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2690890Heidlindemann, M., Rulli, G., Berkessel, A., Hummel, W., Gröger, H.: Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catalysis. 4, 1099-1103 (2014).PUB | DOI | WoS
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2681761Greschner, W., Lanzerath, C., Reß, T., Tenbrink, K., Borchert, S., Mix, A., Hummel, W., Gröger, H.: Artificial cofactor regeneration with an iron(III)porphyrin as NADH-oxidase mimic in the enzymatic oxidation of L-glutamate to alpha-ketoglutarate. Journal of Molecular Catalysis B Enzymatic. 103, 10-15 (2014).PUB | DOI | WoS
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2682298Gröger, H., Hummel, W.: Combining the 'two worlds' of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media. Current opinion in chemical biology. 19, 171-179 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2612864Mueller, C.A., Akkapurathu, B., Winkler, T., Staudt, S., Hummel, W., Gröger, H., Schwaneberg, U.: In Vitro Double Oxidation of n-Heptane with Direct Cofactor Regeneration. Advanced Synthesis & Catalysis. 355, 1787-1798 (2013).PUB | DOI | WoS
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2560792Staudt, S., Burda, E., Giese, C., Müller, C.A., Marienhagen, J., Schwaneberg, U., Hummel, W., Drauz, K., Gröger, H.: Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water. Angewandte Chemie International Edition. 52, 2359-2363 (2013).PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2637130Rulli, G., Heidlindemann, M., Berkessel, A., Hummel, W., Gröger, H.: Towards catalyst compartimentation in combined chemo- and biocatalytic processes: Immobilization of alcohol dehydrogenases for the diastereoselective reduction of a β-hydroxy ketone obtained from an organocatalytic aldol reaction. Journal of biotechnology. 168, 271-276 (2013).PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621189Burda, E., Reß, T., Winkler, T., Giese, C., Kostrov, X., Huber, T., Hummel, W., Gröger, H.: Highly Enantioselective Reduction of α-Methylated Nitroalkenes. Angewandte Chemie (International ed. in English). 52, 9323-9326 (2013).PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621177Staudt, S., Bornscheuer, U.T., Menyes, U., Hummel, W., Gröger, H.: Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology. 53, 288-292 (2013).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471821Schnapperelle, I., Hummel, W., Gröger, H.: Formal Asymmetric Hydration of Non-Activated Alkenes in Aqueous Medium through a "Chemoenzymatic Catalytic System". Chemistry - A European Journal. 18, 1073-1076 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397781Hummel, W., Gröger, H.: Reductive Amination of Keto Acids. In: Drauz, K., Gröger, H., and May, O. (eds.) Enzyme Catalysis in Organic Synthesis. 3, 3rd ed. p. 1165-1221. Wiley-VCH, Weinheim (2012).PUB
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397699Gröger, H., Hummel, W., Borchert, S., Kraußer, M.: Reduction of Ketones and Aldehydes to Alcohols. In: Drauz, K., Gröger, H., and May, O. (eds.) Enzyme Catalysis in Organic Synthesis. 2, 3rd ed. Wiley-VCH, Weinheim (2012).PUB
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2445196Borchert, S., Burda, E., Schatz, J., Hummel, W., Gröger, H.: Combination of a Suzuki cross-coupling reaction using a water-soluble palladium catalyst with an asymmetric enzymatic reduction towards a one-pot reaction in aqueous medium at room temperature. J. Mol. Catal. B: Enzym. 84, 89-93 (2012).PUB | DOI | WoS
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2398903Gröger, H., Hummel, W., Metzner, R.: Asymmetric Biocatalytic Reduction of Ketones. In: Carreira, E.M. and Yamamoto, H. (eds.) Synthetic Methods VI – Enzymatic and Semi-Enzymatic. Comprehensive Chirality. 7, p. 181-215. Elsevier, Oxford (2012).PUB | DOI
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407538Maid, H., Böhm, P., Huber, S.M., Bauer, W., Hummel, W., Jux, N., Gröger, H.: Eisenkatalyse zur In-situ-Regenerierung oxidierter Cofaktoren durch Aktivierung und Reduktion von O2: ein synthetisches Metallporphyrin als biomimetische NAD(P)H-Oxidase. Angewandte Chemie. 123, 2445-2448 (2011).PUB | DOI
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344721Maid, H., Boehm, P., Huber, S.M., Bauer, W., Hummel, W., Jux, N., Gröger, H.: Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase. Angewandte Chemie International Edition. 50, 2397-2400 (2011).PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407610Rulli, G., Duangdee, N., Baer, K., Hummel, W., Berkessel, A., Gröger, H.: Gesteuerte kinetisch oder thermodynamisch kontrollierte Organokatalyse und Anwendung in der chemoenzymatischen Synthese. Angew. Chem. 123, 8092-8095 (2011).PUB | DOI
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344713Rulli, G., Duangdee, N., Baer, K., Hummel, W., Berkessel, A., Gröger, H.: Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 50, 7944-7947 (2011).PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344730Richter, N., Gröger, H., Hummel, W.: Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 89, 79-89 (2011).PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344704Krausser, M., Winkler, T., Richter, N., Dommer, S., Fingerhut, A., Hummel, W., Gröger, H.: Combination of C=C Bond Formation by Wittig Reaction and Enzymatic C=C Bond Reduction in a One-Pot Process in Water. ChemCatChem. 3, 293-296 (2011).PUB | DOI | WoS
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2010 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2344784Weckbecker, A., Gröger, H., Hummel, W.: Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds. In: Wittmann, C. and Krull, W.R. (eds.) BIOSYSTEMS ENGINEERING I: CREATING SUPERIOR BIOCATALYSTS. Advances in Biochemical Engineering-Biotechnology. 120, p. 195-242. Springer Berlin Heidelberg, Berlin, Heidelberg (2010).PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344737Dückers, N., Baer, K., Simon, S., Gröger, H., Hummel, W.: Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 88, 409-424 (2010).PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344761Baer, K., Dueckers, N., Hummel, W., Gröger, H.: Expanding the Application Range of Aldolases: Novel Asymmetric Syntheses of alpha-Methylated beta-Hydroxy alpha-Amino Acids and beta-Amino Alcohols. ChemCatChem. 2, 939-942 (2010).PUB | DOI | WoS
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344772Neupert, A., Ress, T., Wittmann, J., Hummel, W., Gröger, H.: Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences. 65, 337-340 (2010).PUB | DOI | WoS