40 Publikationen
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949613Bakonyi, Daniel, Toelzer, Christine, Stricker, Michael, Hummel, Werner, Niefind, Karsten, and Gröger, Harald. 2020. “Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile”. Catalysts 10 (11): 1281.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916563Bakonyi, Daniel, and Hummel, Werner. 2017. “Cloning, expression, and biochemical characterization of a novel NADP(+)-dependent 7 alpha-hydroxysteroid dehydrogenase from Clostridium difficile and its application for the oxidation of bile acids”. ENZYME AND MICROBIAL TECHNOLOGY 99: 16-24.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909081Rulli, Giuseppe, Duangdee, Nongnaphat, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2017. “First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols”. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017 (4): 812-817.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909084Biermann, Marc, Bakonyi, Daniel, Hummel, Werner, and Gröger, Harald. 2017. “Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants”. GREEN CHEMISTRY 19 (2): 405-410.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904890Bulut, Dalia, Duangdee, Nongnaphat, Gröger, Harald, Berkessel, Albrecht, and Hummel, Werner. 2016. “Screening, Molecular Cloning, and Biochemical Characterization of an Alcohol Dehydrogenase from Pichia pastoris Useful for the Kinetic Resolution of a Racemic β-Hydroxy-β-trifluoromethyl Ketone”. Chembiochem 17 (14): 1349-1358.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2764353Metzner, Richard, Hummel, Werner, Wetterich, Frank, Koenig, Burghard, and Gröger, Harald. 2015. “Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block”. Organic Process Research & Development 19 (6): 635-638.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2721884Schmidt, Sandy, Scherkus, Christian, Muschiol, Jan, Menyes, Ulf, Winkler, Till, Hummel, Werner, Gröger, Harald, Liese, Andreas, Herz, Hans-Georg, and Bornscheuer, Uwe T. 2015. “An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers”. Angewandte Chemie (International ed. in English) 54 (9): 2784-2787.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729781Sato, Hirofumi, Hummel, Werner, and Gröger, Harald. 2015. “Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Media”. Angewandte Chemie (International ed. in English) 54 (15): 4488-4492.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2759821Engels, Leonie, Henze, Manja, Hummel, Werner, and Elling, Lothar. 2015. “Enzyme Module Systems for the Synthesis of Uridine 5 '-Diphospho-alpha-D-glucuronic Acid and Non-Sulfated Human Natural Killer Cell-1 (HNK-1) Epitope”. Advanced Synthesis & Catalysis 357 (8): 1751-1762.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2758474Reß, Tina, Hummel, Werner, Hanlon, Steven P., Iding, Hans, and Gröger, Harald. 2015. “The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization”. ChemCatChem 7 (8): 1302-1311.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2761249Bulut, Dalia, Gröger, Harald, and Hummel, Werner. 2015. “Development of a growth-dependent selection system for identification of L-threonine aldolases”. Applied Microbiology and Biotechnology 99 (14): 5875-5883.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729792Heidlindemann, Marcel, Hammel, Matthias, Scheffler, Ulf, Mahrwald, Rainer, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2015. “Chemoenzymatic Synthesis of Vitamin B5-Intermediate (R)-Pantolactone via Combined Asymmetric Organo- and Biocatalysis”. The Journal of Organic Chemistry 80 (7): 3387-3396.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2677387Winkler, Till, Gröger, Harald, and Hummel, Werner. 2014. “Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from a, b- Unsaturated Aldehydes”. ChemCatChem 6 (4): 961-964.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708863Müller, Christina A., Dennig, Alexander, Welters, Tim, Winkler, Till, Ruff, Anna Joelle, Hummel, Werner, Gröger, Harald, and Schwaneberg, Ulrich. 2014. “Whole-cell double oxidation of n-heptane”. Journal of biotechnology 191: 196-204.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708851Hummel, Werner, and Gröger, Harald. 2014. “Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems”. Journal of biotechnology 191: 22-31.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2690890Heidlindemann, Marcel, Rulli, Giuseppe, Berkessel, Albrecht, Hummel, Werner, and Gröger, Harald. 2014. “Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments”. ACS Catalysis 4 (4): 1099-1103.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2681761Greschner, Wilko, Lanzerath, Carsten, Reß, Tina, Tenbrink, Katharina, Borchert, Sonja, Mix, Andreas, Hummel, Werner, and Gröger, Harald. 2014. “Artificial cofactor regeneration with an iron(III)porphyrin as NADH-oxidase mimic in the enzymatic oxidation of L-glutamate to alpha-ketoglutarate”. Journal of Molecular Catalysis B Enzymatic 103: 10-15.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2682298Gröger, Harald, and Hummel, Werner. 2014. “Combining the 'two worlds' of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media”. Current opinion in chemical biology 19: 171-179.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2612864Mueller, Christina A., Akkapurathu, Beneeta, Winkler, Till, Staudt, Svenja, Hummel, Werner, Gröger, Harald, and Schwaneberg, Ulrich. 2013. “In Vitro Double Oxidation of n-Heptane with Direct Cofactor Regeneration”. Advanced Synthesis & Catalysis 355 (9): 1787-1798.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2560792Staudt, Svenja, Burda, Edyta, Giese, Carolin, Müller, Christina A., Marienhagen, Jan, Schwaneberg, Ulrich, Hummel, Werner, Drauz, Karlheinz, and Gröger, Harald. 2013. “Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water”. Angewandte Chemie International Edition 52 (8): 2359-2363.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2637130Rulli, Giuseppe, Heidlindemann, Marcel, Berkessel, Albrecht, Hummel, Werner, and Gröger, Harald. 2013. “Towards catalyst compartimentation in combined chemo- and biocatalytic processes: Immobilization of alcohol dehydrogenases for the diastereoselective reduction of a β-hydroxy ketone obtained from an organocatalytic aldol reaction”. Journal of biotechnology 168 (3): 271-276.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621189Burda, Edyta, Reß, Tina, Winkler, Till, Giese, Carolin, Kostrov, Xenia, Huber, Tobias, Hummel, Werner, and Gröger, Harald. 2013. “Highly Enantioselective Reduction of α-Methylated Nitroalkenes”. Angewandte Chemie (International ed. in English) 52 (35): 9323-9326.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621177Staudt, Svenja, Bornscheuer, Uwe T, Menyes, Ulf, Hummel, Werner, and Gröger, Harald. 2013. “Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone”. Enzyme and microbial technology 53 (4): 288-292.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471821Schnapperelle, Ingo, Hummel, Werner, and Gröger, Harald. 2012. “Formal Asymmetric Hydration of Non-Activated Alkenes in Aqueous Medium through a "Chemoenzymatic Catalytic System"”. Chemistry - A European Journal 18 (4): 1073-1076.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397781Hummel, Werner, and Gröger, Harald. 2012. “Reductive Amination of Keto Acids”. In Enzyme Catalysis in Organic Synthesis, ed. Karlheinz Drauz, Harald Gröger, and Oliver May, 3rd ed., 3:1165-1221. Weinheim: Wiley-VCH.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397699Gröger, Harald, Hummel, Werner, Borchert, Sonja, and Kraußer, Marina. 2012. “Reduction of Ketones and Aldehydes to Alcohols”. In Enzyme Catalysis in Organic Synthesis, ed. Karlheinz Drauz, Harald Gröger, and Oliver May, 3rd ed. Vol. 2. Weinheim: Wiley-VCH.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2445196Borchert, Sonja, Burda, Edyta, Schatz, Jürgen, Hummel, Werner, and Gröger, Harald. 2012. “Combination of a Suzuki cross-coupling reaction using a water-soluble palladium catalyst with an asymmetric enzymatic reduction towards a one-pot reaction in aqueous medium at room temperature”. J. Mol. Catal. B: Enzym. 84 (SI): 89-93.
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2398903Gröger, Harald, Hummel, Werner, and Metzner, Richard. 2012. “Asymmetric Biocatalytic Reduction of Ketones”. In Synthetic Methods VI – Enzymatic and Semi-Enzymatic, ed. Erick M. Carreira and Hisashi Yamamoto, 7:181-215. Comprehensive Chirality. Oxford: Elsevier.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407538Maid, H., Böhm, P., Huber, S.M., Bauer, W., Hummel, Werner, Jux, N., and Gröger, Harald. 2011. “Eisenkatalyse zur In-situ-Regenerierung oxidierter Cofaktoren durch Aktivierung und Reduktion von O2: ein synthetisches Metallporphyrin als biomimetische NAD(P)H-Oxidase”. Angewandte Chemie 123 (10): 2445-2448.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344721Maid, Harald, Boehm, Philipp, Huber, Stefan M., Bauer, Walter, Hummel, Werner, Jux, Norbert, and Gröger, Harald. 2011. “Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase”. Angewandte Chemie International Edition 50 (10): 2397-2400.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407610Rulli, Giuseppe, Duangdee, Nongnaphat, Baer, Katrin, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2011. “Gesteuerte kinetisch oder thermodynamisch kontrollierte Organokatalyse und Anwendung in der chemoenzymatischen Synthese”. Angew. Chem. 123 (34): 8092-8095.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344713Rulli, Giuseppe, Duangdee, Nongnaphat, Baer, Katrin, Hummel, Werner, Berkessel, Albrecht, and Gröger, Harald. 2011. “Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50 (34): 7944-7947.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344730Richter, Nina, Gröger, Harald, and Hummel, Werner. 2011. “Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 89 (1): 79-89.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344704Krausser, Marina, Winkler, Till, Richter, Nina, Dommer, Sabine, Fingerhut, Anja, Hummel, Werner, and Gröger, Harald. 2011. “Combination of C=C Bond Formation by Wittig Reaction and Enzymatic C=C Bond Reduction in a One-Pot Process in Water”. ChemCatChem 3 (2): 293-296.
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2010 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2344784Weckbecker, Andrea, Gröger, Harald, and Hummel, Werner. 2010. “Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds”. In BIOSYSTEMS ENGINEERING I: CREATING SUPERIOR BIOCATALYSTS, ed. C. Wittmann and W. R. Krull, 120:195-242. Advances in Biochemical Engineering-Biotechnology. Berlin, Heidelberg: Springer Berlin Heidelberg.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344737Dückers, Nina, Baer, Katrin, Simon, Sabine, Gröger, Harald, and Hummel, Werner. 2010. “Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 88 (2): 409-424.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344761Baer, Katrin, Dueckers, Nina, Hummel, Werner, and Gröger, Harald. 2010. “Expanding the Application Range of Aldolases: Novel Asymmetric Syntheses of alpha-Methylated beta-Hydroxy alpha-Amino Acids and beta-Amino Alcohols”. ChemCatChem 2 (8): 939-942.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344772Neupert, Adrian, Ress, Tina, Wittmann, Jürgen, Hummel, Werner, and Gröger, Harald. 2010. “Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones”. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences 65 (3): 337-340.