40 Publikationen
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949613Bakonyi, D., Toelzer, C., Stricker, M., Hummel, W., Niefind, K., & Gröger, H. (2020). Expanding the Application Range of Microbial Oxidoreductases by an Alcohol Dehydrogenase from Comamonas testosteroni with a Broad Substrate Spectrum and pH Profile. Catalysts, 10(11), 1281. doi:10.3390/catal10111281PUB | PDF | DOI | WoS
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916563Bakonyi, D., & Hummel, W. (2017). Cloning, expression, and biochemical characterization of a novel NADP(+)-dependent 7 alpha-hydroxysteroid dehydrogenase from Clostridium difficile and its application for the oxidation of bile acids. ENZYME AND MICROBIAL TECHNOLOGY, 99, 16-24. doi:10.1016/j.enzmictec.2016.12.006PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909081Rulli, G., Duangdee, N., Hummel, W., Berkessel, A., & Gröger, H. (2017). First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017(4), 812-817. doi:10.1002/ejoc.201600831PUB | DOI | WoS
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909084Biermann, M., Bakonyi, D., Hummel, W., & Gröger, H. (2017). Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants. GREEN CHEMISTRY, 19(2), 405-410. doi:10.1039/c6gc01668ePUB | DOI | WoS
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904890Bulut, D., Duangdee, N., Gröger, H., Berkessel, A., & Hummel, W. (2016). Screening, Molecular Cloning, and Biochemical Characterization of an Alcohol Dehydrogenase from Pichia pastoris Useful for the Kinetic Resolution of a Racemic β-Hydroxy-β-trifluoromethyl Ketone. Chembiochem, 17(14), 1349-1358. doi:10.1002/cbic.201600101PUB | DOI | WoS | PubMed | Europe PMC
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2917152Biermann, M., Gruß, H., Hummel, W., & Gröger, H. (2016). Guerbet Alcohols: From Processes under Harsh Conditions to Synthesis at Room Temperature under Ambient Pressure. CHEMCATCHEM, 8(5), 895-899. doi:10.1002/cctc.201501241PUB | DOI | WoS
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2764353Metzner, R., Hummel, W., Wetterich, F., Koenig, B., & Gröger, H. (2015). Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block. Organic Process Research & Development, 19(6), 635-638. doi:10.1021/acs.oprd.5b00057PUB | DOI | WoS
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2721884Schmidt, S., Scherkus, C., Muschiol, J., Menyes, U., Winkler, T., Hummel, W., Gröger, H., et al. (2015). An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers. Angewandte Chemie (International ed. in English), 54(9), 2784-2787. doi:10.1002/anie.201410633PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729781Sato, H., Hummel, W., & Gröger, H. (2015). Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Media. Angewandte Chemie (International ed. in English), 54(15), 4488-4492. doi:10.1002/anie.201409590PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2759821Engels, L., Henze, M., Hummel, W., & Elling, L. (2015). Enzyme Module Systems for the Synthesis of Uridine 5 '-Diphospho-alpha-D-glucuronic Acid and Non-Sulfated Human Natural Killer Cell-1 (HNK-1) Epitope. Advanced Synthesis & Catalysis, 357(8), 1751-1762. doi:10.1002/adsc.201500180PUB | DOI | WoS
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2758474Reß, T., Hummel, W., Hanlon, S. P., Iding, H., & Gröger, H. (2015). The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization. ChemCatChem, 7(8), 1302-1311. doi:10.1002/cctc.201402903PUB | DOI | WoS
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2761249Bulut, D., Gröger, H., & Hummel, W. (2015). Development of a growth-dependent selection system for identification of L-threonine aldolases. Applied Microbiology and Biotechnology, 99(14), 5875-5883. doi:10.1007/s00253-014-6333-zPUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2729792Heidlindemann, M., Hammel, M., Scheffler, U., Mahrwald, R., Hummel, W., Berkessel, A., & Gröger, H. (2015). Chemoenzymatic Synthesis of Vitamin B5-Intermediate (R)-Pantolactone via Combined Asymmetric Organo- and Biocatalysis. The Journal of Organic Chemistry, 80(7), 3387-3396. doi:10.1021/jo502667xPUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2677387Winkler, T., Gröger, H., & Hummel, W. (2014). Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from a, b- Unsaturated Aldehydes. ChemCatChem, 6(4), 961-964. doi:10.1002/cctc.201300764PUB | DOI | WoS
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708863Müller, C. A., Dennig, A., Welters, T., Winkler, T., Ruff, A. J., Hummel, W., Gröger, H., et al. (2014). Whole-cell double oxidation of n-heptane. Journal of biotechnology, 191, 196-204. doi:10.1016/j.jbiotec.2014.06.001PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2708851Hummel, W., & Gröger, H. (2014). Strategies for regeneration of nicotinamide coenzymes emphasizing self-sufficient closed-loop recycling systems. Journal of biotechnology, 191, 22-31. doi:10.1016/j.jbiotec.2014.07.449PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2690890Heidlindemann, M., Rulli, G., Berkessel, A., Hummel, W., & Gröger, H. (2014). Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments. ACS Catalysis, 4(4), 1099-1103. doi:10.1021/cs4010387PUB | DOI | WoS
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2681761Greschner, W., Lanzerath, C., Reß, T., Tenbrink, K., Borchert, S., Mix, A., Hummel, W., et al. (2014). Artificial cofactor regeneration with an iron(III)porphyrin as NADH-oxidase mimic in the enzymatic oxidation of L-glutamate to alpha-ketoglutarate. Journal of Molecular Catalysis B Enzymatic, 103, 10-15. doi:10.1016/j.molcatb.2013.12.015PUB | DOI | WoS
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2682298Gröger, H., & Hummel, W. (2014). Combining the 'two worlds' of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media. Current opinion in chemical biology, 19, 171-179. doi:10.1016/j.cbpa.2014.03.002PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2612864Mueller, C. A., Akkapurathu, B., Winkler, T., Staudt, S., Hummel, W., Gröger, H., & Schwaneberg, U. (2013). In Vitro Double Oxidation of n-Heptane with Direct Cofactor Regeneration. Advanced Synthesis & Catalysis, 355(9), 1787-1798. doi:10.1002/adsc.201300143PUB | DOI | WoS
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2560792Staudt, S., Burda, E., Giese, C., Müller, C. A., Marienhagen, J., Schwaneberg, U., Hummel, W., et al. (2013). Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water. Angewandte Chemie International Edition, 52(8), 2359-2363. doi:10.1002/anie.201204464PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2637130Rulli, G., Heidlindemann, M., Berkessel, A., Hummel, W., & Gröger, H. (2013). Towards catalyst compartimentation in combined chemo- and biocatalytic processes: Immobilization of alcohol dehydrogenases for the diastereoselective reduction of a β-hydroxy ketone obtained from an organocatalytic aldol reaction. Journal of biotechnology, 168(3), 271-276. doi:10.1016/j.jbiotec.2013.08.031PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621189Burda, E., Reß, T., Winkler, T., Giese, C., Kostrov, X., Huber, T., Hummel, W., et al. (2013). Highly Enantioselective Reduction of α-Methylated Nitroalkenes. Angewandte Chemie (International ed. in English), 52(35), 9323-9326. doi:10.1002/anie.201301814PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2621177Staudt, S., Bornscheuer, U. T., Menyes, U., Hummel, W., & Gröger, H. (2013). Direct biocatalytic one-pot-transformation of cyclohexanol with molecular oxygen into ɛ-caprolactone. Enzyme and microbial technology, 53(4), 288-292. doi:10.1016/j.enzmictec.2013.03.011PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471821Schnapperelle, I., Hummel, W., & Gröger, H. (2012). Formal Asymmetric Hydration of Non-Activated Alkenes in Aqueous Medium through a "Chemoenzymatic Catalytic System". Chemistry - A European Journal, 18(4), 1073-1076. https://doi.org/10.1002/chem.201102579PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397781Hummel, W., & Gröger, H. (2012). Reductive Amination of Keto Acids. In K. Drauz, H. Gröger, & O. May (Eds.), Enzyme Catalysis in Organic Synthesis (3rd ed., Vol. 3, pp. 1165-1221). Weinheim: Wiley-VCH.PUB
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2397699Gröger, H., Hummel, W., Borchert, S., & Kraußer, M. (2012). Reduction of Ketones and Aldehydes to Alcohols. In K. Drauz, H. Gröger, & O. May (Eds.), Enzyme Catalysis in Organic Synthesis (3rd ed., Vol. 2). Weinheim: Wiley-VCH.PUB
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2445196Borchert, S., Burda, E., Schatz, J., Hummel, W., & Gröger, H. (2012). Combination of a Suzuki cross-coupling reaction using a water-soluble palladium catalyst with an asymmetric enzymatic reduction towards a one-pot reaction in aqueous medium at room temperature. J. Mol. Catal. B: Enzym., 84(SI), 89-93. https://doi.org/10.1016/j.molcatb.2012.03.006PUB | DOI | WoS
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2012 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2398903Gröger, H., Hummel, W., & Metzner, R. (2012). Asymmetric Biocatalytic Reduction of Ketones. In E. M. Carreira & H. Yamamoto (Eds.), Comprehensive Chirality: Vol. 7. Synthetic Methods VI – Enzymatic and Semi-Enzymatic (pp. 181-215). Oxford: Elsevier. https://doi.org/10.1016/b978-0-08-095167-6.00712-6PUB | DOI
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407538Maid, H., Böhm, P., Huber, S. M., Bauer, W., Hummel, W., Jux, N., & Gröger, H. (2011). Eisenkatalyse zur In-situ-Regenerierung oxidierter Cofaktoren durch Aktivierung und Reduktion von O2: ein synthetisches Metallporphyrin als biomimetische NAD(P)H-Oxidase. Angewandte Chemie, 123(10), 2445-2448. https://doi.org/10.1002/ange.201004101PUB | DOI
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344721Maid, H., Boehm, P., Huber, S. M., Bauer, W., Hummel, W., Jux, N., & Gröger, H. (2011). Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase. Angewandte Chemie International Edition, 50(10), 2397-2400. https://doi.org/10.1002/anie.201004101PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2407610Rulli, G., Duangdee, N., Baer, K., Hummel, W., Berkessel, A., & Gröger, H. (2011). Gesteuerte kinetisch oder thermodynamisch kontrollierte Organokatalyse und Anwendung in der chemoenzymatischen Synthese. Angew. Chem., 123(34), 8092-8095. https://doi.org/10.1002/ange.201008042PUB | DOI
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344713Rulli, G., Duangdee, N., Baer, K., Hummel, W., Berkessel, A., & Gröger, H. (2011). Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(34), 7944-7947. https://doi.org/10.1002/anie.201008042PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344730Richter, N., Gröger, H., & Hummel, W. (2011). Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 89(1), 79-89. https://doi.org/10.1007/s00253-010-2793-yPUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344704Krausser, M., Winkler, T., Richter, N., Dommer, S., Fingerhut, A., Hummel, W., & Gröger, H. (2011). Combination of C=C Bond Formation by Wittig Reaction and Enzymatic C=C Bond Reduction in a One-Pot Process in Water. ChemCatChem, 3(2), 293-296. https://doi.org/10.1002/cctc.201000391PUB | DOI | WoS
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2010 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2344784Weckbecker, A., Gröger, H., & Hummel, W. (2010). Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds. In C. Wittmann & W. R. Krull (Eds.), Advances in Biochemical Engineering-Biotechnology: Vol. 120. BIOSYSTEMS ENGINEERING I: CREATING SUPERIOR BIOCATALYSTS (pp. 195-242). Berlin, Heidelberg: Springer Berlin Heidelberg. https://doi.org/10.1007/10_2009_55PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344737Dückers, N., Baer, K., Simon, S., Gröger, H., & Hummel, W. (2010). Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic beta-hydroxy-alpha-amino acids. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 88(2), 409-424. https://doi.org/10.1007/s00253-010-2751-8PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344778Burda, E., Bauer, W., Hummel, W., & Gröger, H. (2010). Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols. ChemCatChem, 2(1), 67-72. https://doi.org/10.1002/cctc.200900156PUB | DOI | WoS
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344761Baer, K., Dueckers, N., Hummel, W., & Gröger, H. (2010). Expanding the Application Range of Aldolases: Novel Asymmetric Syntheses of alpha-Methylated beta-Hydroxy alpha-Amino Acids and beta-Amino Alcohols. ChemCatChem, 2(8), 939-942. https://doi.org/10.1002/cctc.201000007PUB | DOI | WoS
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2344772Neupert, A., Ress, T., Wittmann, J., Hummel, W., & Gröger, H. (2010). Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones. Zeitschrift für Naturforschung. Section B, a journal of chemical sciences, 65(3), 337-340. https://doi.org/10.1515/znb-2010-0317PUB | DOI | WoS