56 Publikationen
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2969198Stoeger, Thomas, Grant, Rogan A., McQuattie-Pimentel, Alexandra C., Anekalla, Kishore R., Liu, Sophia S., Tejedor-Navarro, Heliodoro, Singer, Benjamin D., et al. 2022. “Aging is associated with a systemic length-associated transcriptome imbalance”. Nature Aging 2 (12): 1191-1206.
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2959493Donkervoort, Sandra, Krause, Niklas, Dergai, Mykola, Yun, Pomi, Koliwer, Judith, Gorokhova, Svetlana, Hauserman, Janelle Geist, et al. 2021. “BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy”. EMBO Molecular Medicine : e13787.
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2020 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2948754Saminathan, Anand, Devany, John, Veetil, Aneesh Tazhe, Suresh, Bhavyashree, Pillai, Kavya Smitha, Schwake, Michael, and Krishnan, Yamuna. 2020. “A DNA-based voltmeter for organelles”. Nature Nanotechnology.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936923Heybrock, Saskia, Kanerva, Kristiina, Meng, Ying, Ing, Chris, Liang, Anna, Xiong, Zi-Jian, Weng, Xialian, et al. 2019. “Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export”. Nature Communications 10 (1): 3521.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2931407Strigli, Anne, Raab, Christian, Hessler, Sabine, Huth, Tobias, Schuldt, Adam J. T., Alzheimer, Christian, Friedrich, Thomas, Burridge, Paul W., Luedde, Mark, and Schwake, Michael. 2018. “Doxorubicin induces caspase-mediated proteolysis of KV7.1”. Communications Biology 1 (1): 155.
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2932410Donkervoort, S., Hu, Y., Shieh, P., Koliwer, Judith, Tsai, L., Cummings, B., Snyder, M., et al. 2018. “Recessive mutations in BET1 and GOSR2 establish Q-SNARE Golgi-vesicle-transport genes as a cause for congenital muscular dystrophy with epilepsy”. NEUROMUSCULAR DISORDERS 28 (Suppl. 2): S30.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953333Conrad, Karen S., Cheng, Ting-Wen, Ysselstein, Daniel, Heybrock, Saskia, Hoth, Lise R., Chrunyk, Boris A., am Ende, Christopher W., et al. 2017. “Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies”. Nature Communications 8 (1): 1908.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953334Valdez, Clarissa, Wong, Yvette C, Schwake, Michael, Bu, Guojun, Wszolek, Zbigniew K, and Krainc, Dimitri. 2017. “Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients”. Human Molecular Genetics 26 (24): 4861-4872.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916109Rujano, Maria A., Serio, Magda Cannata, Panasyuk, Ganna, P, Romain Anne, Reunert, Janine, Rymen, Daisy, Hauser, Virginie, et al. 2017. “Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects”. JOURNAL OF EXPERIMENTAL MEDICINE 214 (12): 3707-3729.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2916411Völker, Jörn Michael, Dergai, Mykola, Abriata, Luciano A., Mingard, Yves, Ysselstein, Daniel, Krainc, Dimitri, Dal Peraro, Matteo, et al. 2017. “Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies”. DISEASE MODELS & MECHANISMS 10 (12): 1391-1398.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953335Zheng, Jianbin, Chen, Long, Schwake, Michael, Silverman, Richard B., and Krainc, Dimitri. 2016. “Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators”. Journal of Medicinal Chemistry 59 (18): 8508-8520.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2903027Zunke, Friederike, Andresen, Lisa, Wesseler, Sophia, Groth, Johann, Arnold, Philipp, Rothaug, Michelle, Mazzulli, Joseph R., et al. 2016. “Characterization of the complex formed by beta-glucocerebrosidase and the lysosomal integral membrane protein type-2”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113 (14): 3791-3796.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2904109Kook, Seunghyi, Wang, Ping, Young, Lisa R., Schwake, Michael, Saftig, Paul, Weng, Xialian, Meng, Ying, et al. 2016. “Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice”. JOURNAL OF BIOLOGICAL CHEMISTRY 291 (16): 8414-8427.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2901299Agsten, Marianne, Hessler, Sabine, Lehnert, Sandra, Volk, Tilmann, Rittger, Andrea, Hartmann, Stephanie, Raab, Christian, et al. 2015. “BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (I-Ks)”. Journal of Molecular and Cellular Cardiology 89 (pt b): 335-348.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2731234Hessler, Sabine, Zheng, Fang, Hartmann, Stephanie, Rittger, Andrea, Lehnert, Sandra, Voelkel, Meike, Nissen, Matthias, et al. 2015. “beta-Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a beta-Subunit-Like Fashion”. Journal of Neuroscience 35 (8): 3298-3311.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2731248Peters, Judith, Rittger, Andrea, Weisner, Rebecca, Knabbe, Johannes, Zunke, Friederike, Rothaug, Michelle, Damme, Markus, et al. 2015. “Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease”. Biochemical and Biophysical Research Communications 457 (3): 334-340.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2901039Blanz, Judith, Zunke, Friederike, Markmann, Sandra, Damme, Markus, Braulke, Thomas, Saftig, Paul, and Schwake, Michael. 2015. “Mannose 6-phosphate-independent Lysosomal Sorting of Limp-2”. Traffic 16 (10): 1127-1136.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2759802Kissing, Sandra, Hermsen, Christina, Repnik, Urska, Nesset, Cecilie Kasi, von Bargen, Kristine, Griffiths, Gareth, Ichihara, Atsuhiro, et al. 2015. “Vacuolar ATPase in Phagosome-Lysosome Fusion”. Journal of Biological Chemistry 290 (22): 14166-14180.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2671368Lemke, Johannes R., Hendrickx, Rik, Geider, Kirsten, Laube, Bodo, Schwake, Michael, Harvey, Robert J., James, Victoria M., et al. 2014. “GRIN2B Mutations in West Syndrome and Intellectual Disability with Focal Epilepsy”. Annals of Neurology 75 (1): 147-154.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2660866Gaspar, Paulo, Kallemeijn, Wouter W., Strijland, Anneke, Scheij, Saskia, Van Eijk, Marco, Aten, Jan, Overkleeft, Herman S., et al. 2014. “Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis”. The Journal of Lipid Research 55 (1): 138-145.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2694992Rosendahl, Alva, Niemann, Gianina, Lange, Sascha, Ahadzadeh, Erfan, Krebs, Christian, Contrepas, Aurelie, van Goor, Harry, et al. 2014. “Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice”. Laboratory Investigation 94 (8): 863-872.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2707698Rothaug, Michelle, Zunke, Friederike, Mazzulli, Joseph R., Schweizer, Michaela, Altmeppen, Hermann, Luellmann-Rauch, Renate, Kallemeijn, Wouter W., et al. 2014. “LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance”. Proceedings of the National Academy of Sciences 111 (43): 15573-15578.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2681867Schwarz, Jeanette, Schmidt, Stefanie, Will, Olga, Koudelka, Tomas, Koehler, Kaja, Boss, Melanie, Rabe, Bjoern, et al. 2014. “Polo-like Kinase 2, a Novel ADAM17 Signaling Component, Regulates Tumor Necrosis Factor similar to Ectodomain Shedding”. Journal of Biological Chemistry 289 (5): 3080-3093.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953336Smith, K. R., Dahl, H.-H. M., Canafoglia, L., Andermann, E., Damiano, J., Morbin, M., Bruni, A. C., et al. 2013. “Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis”. Human Molecular Genetics 22 (7): 1417-1423.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953337Schwake, Michael, Schröder, Bernd, and Saftig, Paul. 2013. “Lysosomal Membrane Proteins and Their Central Role in Physiology”. Traffic 14 (7): 739-748.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953338Schmid, Johannes, Oelbe, Miriam, Saftig, Paul, Schwake, Michael, and Schweda, Frank. 2013. “Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles”. Pflügers Archiv - European Journal of Physiology 465 (6): 895-905.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953339Boehlen, A, Schwake, Michael, Dost, R, Kunert, A, Fidzinski, P, Heinemann, U, and Gebhardt, C. 2013. “The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential”. British Journal of Pharmacology 168 (5): 1182-1200.
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2013 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2953341Schwake, Michael, and Saftig, Paul. 2013. “Lysosomal Membrane Defects”. In Lysosomal Storage Disorders. A Practical Guide, ed. Atul Mehta and Bryan Winchester, 131-136. Oxford: Wiley-Blackwell.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2625613Lemke, Johannes R., Lal, Dennis, Reinthaler, Eva M., Steiner, Isabelle, Nothnagel, Michael, Alber, Michael, Geider, Kirsten, et al. 2013. “Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes”. Nature Genetics 45 (9): 1067-1072.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2645175Neculai, Dante, Schwake, Michael, Ravichandran, Mani, Zunke, Friederike, Collins, Richard F., Peters, Judith, Neculai, Mirela, et al. 2013. “Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36”. Nature 504 (7478): 172-176.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953340Zachos, Christina, Blanz, Judith, Saftig, Paul, and Schwake, Michael. 2012. “A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase”. Traffic 13 (8): 1113-1123.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953342Chadha, Preet S., Zunke, Friederike, Davis, Alison J., Jepps, Thomas A., Linders, Joannes T. M., Schwake, Michael, Towart, Rob, and Greenwood, Iain A. 2012. “Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries”. British Journal of Pharmacology 166 (4): 1377-1387.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953343Prox, Johannes, Willenbrock, Michael, Weber, Silvio, Lehmann, Tobias, Schmidt-Arras, Dirk, Schwanbeck, Ralf, Saftig, Paul, and Schwake, Michael. 2012. “Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10”. Cellular and Molecular Life Sciences 69 (17): 2919-2932.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953344Corbett, Mark A., Schwake, Michael, Bahlo, Melanie, Dibbens, Leanne M., Lin, Meng, Gandolfo, Luke C., Vears, Danya F., et al. 2011. “A Mutation in the Golgi Qb-SNARE Gene GOSR2 Causes Progressive Myoclonus Epilepsy with Early Ataxia”. The American Journal of Human Genetics 88 (5): 657-663.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953345Valkova, C., Albrizio, M., Roder, I. V., Schwake, Michael, Betto, R., Rudolf, R., and Kaether, C. 2011. “Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits”. Proceedings of the National Academy of Sciences 108 (2): 621-625.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953346Desmond, M. J., Lee, D., Fraser, S. A., Katerelos, M., Gleich, K., Martinello, P., Li, Y. Q., et al. 2011. “Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2”. American Journal of Physiology-Renal Physiology 300 (6): F1437-F1447.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953347Blanz, Judith, Groth, Johann, Zachos, Christina, Wehling, Christina, Saftig, Paul, and Schwake, Michael. 2010. “Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand β-glucocerebrosidase”. Human Molecular Genetics 19 (4): 563-572.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953348Lange, Wienke, Geißendörfer, Jan, Schenzer, Anne, Grötzinger, Joachim, Seebohm, Guiscard, Friedrich, Thomas, and Schwake, Michael. 2009. “Refinement of the Binding Site and Mode of Action of the Anticonvulsant Retigabine on KCNQ K Channels”. Molecular Pharmacology 75 (2): 272-280.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953349Yeung, S Y M, Schwake, Michael, Pucovský, V, and Greenwood, I A. 2008. “Bimodal effects of the K 7 channel activator retigabine on vascular K+ currents”. British Journal of Pharmacology 155 (1): 62-72.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953350Yeung, Shuk Yin M., Lange, Wienke, Schwake, Michael, and Greenwood, Iain A. 2008. “Expression profile and characterisation of a truncated KCNQ5 splice variant”. Biochemical and Biophysical Research Communications 371 (4): 741-746.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953351Yamasaki, Ryo, Zhang, Jian, Koshiishi, Ichiro, Sastradipura Suniarti, Dewi F., Wu, Zhou, Peters, Christoph, Schwake, Michael, et al. 2007. “Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice”. Molecular and Cellular Neuroscience 35 (4): 573-584.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953352Reczek, David, Schwake, Michael, Schröder, Jenny, Hughes, Heather, Blanz, Judith, Jin, Xiaoying, Brondyk, William, Van Patten, Scott, Edmunds, Tim, and Saftig, Paul. 2007. “LIMP-2 Is a Receptor for Lysosomal Mannose-6-Phosphate-Independent Targeting of β-Glucocerebrosidase”. Cell 131 (4): 770-783.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953353Schroen, Blanche, Leenders, Joost J., van Erk, Arie, Bertrand, Anne T., van Loon, Mirjam, van Leeuwen, Rick E., Kubben, Nard, et al. 2007. “Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy”. Journal of Experimental Medicine 204 (5): 1227-1235.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953354Wehling, Christina, Beimgraben, Christian, Gelhaus, Christoph, Friedrich, Thomas, Saftig, Paul, Grötzinger, Joachim, and Schwake, Michael. 2007. “Self-assembly of the isolated KCNQ2 subunit interaction domain”. FEBS Letters 581 (8): 1594-1598.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953358Schwake, Michael. 2006. “Structural Determinants of M-Type KCNQ (Kv7) K+ Channel Assembly”. Journal of Neuroscience 26 (14): 3757-3766.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953355Knipper, Marlies, Claussen, Cathrin, Rüttiger, Lukas, Zimmermann, Ulrike, Lüllmann-Rauch, Renate, Eskelinen, Eeva-Liisa, Schröder, Jenny, Schwake, Michael, and Saftig, Paul. 2006. “Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis”. The Journal of Physiology 576 (1): 73-86.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953356Caeyenberghs, Karen, Balschun, Detlef, Roces, Diego Prieto, Schwake, Michael, Saftig, Paul, and D'Hooge, Rudi. 2006. “Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment”. Neurobiology of Disease 23 (2): 422-432.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953357Pachnio, A, Dietrich, S, Klapper, W, Humpe, A, Schwake, Michael, Sedlacek, R, Gramatzki, M, and Beck, C. 2006. “Proliferation-based T-cell selection for immunotherapy and graft-versus-host-disease prophylaxis in the context of bone marrow transplantation”. Bone Marrow Transplantation 38 (2): 157-167.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953361Dominguez, Diana, Tournoy, Jos, Hartmann, Dieter, Huth, Tobias, Cryns, Kim, Deforce, Siska, Serneels, Lutgarde, et al. 2005. “Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice”. Journal of Biological Chemistry 280 (35): 30797-30806.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953360D'Hooge, Rudi, Lüllmann-Rauch, Renate, Beckers, Tom, Balschun, Detlef, Schwake, Michael, Reiss, Karina, von Figura, Kurt, and Saftig, Paul. 2005. “Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human α-Mannosidosis”. Journal of Neuroscience 25 (28): 6539-6549.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953359Schenzer, Anne, Friedrich, Thomas, Pusch, Michael, Saftig, Paul, Jentsch, Thomas J., Grötzinger, Joachim, and Schwake, Michael. 2005. “Molecular Determinants of KCNQ (Kv7) K+ Channel Sensitivity to the Anticonvulsant Retigabine”. Journal of Neuroscience 25 (20): 5051-5060.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953362Schwake, Michael, Jentsch, Thomas J, and Friedrich, Thomas. 2003. “A carboxy‐terminal domain determines the subunit specificity of KCNQ K+ channel assembly”. EMBO reports 4 (1): 76-81.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953363Schwake, Michael, Friedrich, Thomas, and Jentsch, Thomas J. 2001. “An Internalization Signal in ClC-5, an Endosomal Cl−Channel Mutated in Dent's Disease”. Journal of Biological Chemistry 276 (15): 12049-12054.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953364Piwon, Nils, Günther, Willy, Schwake, Michael, Bösl, Michael R., and Jentsch, Thomas J. 2000. “ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease”. Nature 408 (6810): 369-373.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2953365Schwake, Michael, Pusch, Michael, Kharkovets, Tatjana, and Jentsch, Thomas J. 2000. “Surface Expression and Single Channel Properties of KCNQ2/KCNQ3, M-type K+ Channels Involved in Epilepsy”. Journal of Biological Chemistry 275 (18): 13343-13348.