32 Publikationen
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1617209Schroder, J, Wenzel, Herbert, Stammler, Hans-Georg, Stammler, A, Neumann, B, and Tschesche, Harald. 2001. “Novel heterocyclic inhibitors of matrix metalloproteinases: three 6H-1,3,4-thiadiazines”. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS 57 (5): 593-596.
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1616195Schröder, J., Henke, A, Wenzel, Herbert, Brandstetter, H, Stammler, Hans-Georg, Stammler, A, Pfeiffer, WD, and Tschesche, Harald. 2001. “Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold”. JOURNAL OF MEDICINAL CHEMISTRY 44 (20): 3231-3243.
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1624672Krumme, D, Wenzel, Herbert, and Tschesche, Harald. 1998. “Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases”. FEBS LETTERS 436 (2): 209-212.
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1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1628000Brinkmann, T, Korfer, R, Wenzel, Herbert, Tschesche, Harald, and Kleesiek, Knut. 1997. “Strong crossreaction of human anti-aprotinin antibodies from heart transplant patient with [Arg(15)]aprotinin”. IMMUNOPHARMACOLOGY 35 (3): 221-228.
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1995 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1641415WACHTFOGEL, YT, HACK, CE, NUIJENS, JH, KETTNER, C, REILLY, TM, KNABB, RM, BISCHOFF, R, et al. 1995. “SELECTIVE KALLIKREIN INHIBITORS ALTER HUMAN NEUTROPHIL ELASTASE RELEASE DURING EXTRACORPOREAL-CIRCULATION”. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 268 (3): H1352-H1357.
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1994 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1642944GROEGER, C, Wenzel, Herbert, and Tschesche, Harald. 1994. “BPTI BACKBONE VARIANTS AND IMPLICATIONS FOR INHIBITORY ACTIVITY”. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 44 (2): 166-172.
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1993 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1645607GROEGER, C, Wenzel, Herbert, and Tschesche, Harald. 1993. “THE IMPORTANCE OF THE RIGIDITY OF THE PEPTIDE BACKBONE FOR THE INHIBITORY PROPERTIES OF BPTI DEMONSTRATED BY SEMISYNTHETIC STRUCTURAL VARIANTS”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 32 (6): 898-900.
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1991 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 1629600Tschesche, Harald, Groeger, C., and Wenzel, Herbert. 1991. “ENZYMATIC FRAGMENT SUBSTITUTION AS A TOOL IN PROTEIN DESIGN”. In Emerg Med J, 50:S175-S180. BIOMEDICA BIOCHIMICA ACTA. AKADEMIE VERLAG GMBH.
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1991 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1649242GROEGER, C, Wenzel, Herbert, and Tschesche, Harald. 1991. “CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS”. JOURNAL OF PROTEIN CHEMISTRY 10 (5): 527-533.
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1991 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1649962GROEGER, C, Wenzel, Herbert, and Tschesche, Harald. 1991. “ENZYMATIC SEMISYNTHESIS OF APROTININ HOMOLOGS MUTATED IN P' POSITIONS”. JOURNAL OF PROTEIN CHEMISTRY 10 (2): 245-251.
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1990 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1650922Wenzel, Herbert, FELDMANN, A, ENGELBRECHT, S, and Tschesche, Harald. 1990. “ACTIVATION OF THE HUMAN-LEUKOCYTE PROTEINASES ELASTASE AND CATHEPSIN-G BY VARIOUS SURFACTANTS”. BIOLOGICAL CHEMISTRY HOPPE-SEYLER 371 (2): 721-724.
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1989 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1652842MEHLICH, A, BECKMANN, J, Wenzel, Herbert, and Tschesche, Harald. 1989. “SEMISYNTHETIC APROTININ DERIVATIVES WITH SPECIFIC ALTERATIONS AT THE REACTIVE-SITE PEPTIDE-BOND CAN BE USED TO STUDY STRUCTURE-FUNCTION-RELATIONSHIPS”. BIOCHIMICA ET BIOPHYSICA ACTA 996 (1-2): 23-29.
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1989 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1652670SIEKMANN, J, BECKMANN, J, MEHLICH, A, Wenzel, Herbert, Tschesche, Harald, SCHNABEL, E, and MULLERESTERL, W. 1989. “IMMUNOLOGICAL CHARACTERIZATION OF NATURAL AND SEMISYNTHETIC APROTININ VARIANTS”. BIOLOGICAL CHEMISTRY HOPPE-SEYLER 370 (2): 677-682.
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1989 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1653324BECKMANN, J, MEHLICH, A, SCHRODER, W, Wenzel, Herbert, and Tschesche, Harald. 1989. “SEMISYNTHESIS OF ARG-15-APROTININ, GLU-15-APROTININ, MET-15-APROTININ, AND NLE15-APROTININ INVOLVING ENZYMATIC PEPTIDE-BOND RESYNTHESIS”. JOURNAL OF PROTEIN CHEMISTRY 8 (1): 101-113.
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1988 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1653441MEHLICH, A, BECKMANN, J, Wenzel, Herbert, and Tschesche, Harald. 1988. “APROTININ DERIVATIVES WITH CHROMOPHORIC LEAVING GROUPS CAN BE USED AS HIGHLY SELECTIVE ACTIVE-SITE TITRANTS FOR SERINE PROTEINASES AND PERMIT THE DETERMINATION OF KINETIC CONSTANTS OF ENZYME-INHIBITOR COMPLEXES”. BIOCHIMICA ET BIOPHYSICA ACTA 957 (3): 420-429.
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1988 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1653768BECKMANN, J, MEHLICH, A, SCHRODER, W, Wenzel, Herbert, and Tschesche, Harald. 1988. “PREPARATION OF CHEMICALLY MUTATED APROTININ HOMOLOGS BY SEMISYNTHESIS - P1 SUBSTITUTIONS CHANGE INHIBITORY SPECIFICITY”. EUROPEAN JOURNAL OF BIOCHEMISTRY 176 (3): 675-682.
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1988 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1654061SCHNABEL, E, REINHARDT, G, SCHRODER, W, Tschesche, Harald, Wenzel, Herbert, and MEHLICH, A. 1988. “ENZYMATIC RESYNTHESIS OF THE REACTIVE SITE BOND IN THE MODIFIED APROTININ DERIVATIVES [SECO-15/16]APROTININ AND [DI-SECO-15/16,39/40]APROTININ”. BIOLOGICAL CHEMISTRY HOPPE-SEYLER 369 (1): 461-468.
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1988 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1654439SIEKMANN, J, Wenzel, Herbert, SCHRODER, W, and Tschesche, Harald. 1988. “CHARACTERIZATION AND SEQUENCE DETERMINATION OF 6 APROTININ HOMOLOGS FROM BOVINE LUNGS”. BIOLOGICAL CHEMISTRY HOPPE-SEYLER 369 (1): 157-164.
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1988 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1653623SIEKMANN, J, Wenzel, Herbert, MATUSZAK, E, VONGOLDAMMER, E, and Tschesche, Harald. 1988. “THE PH-DEPENDENCE OF THE EQUILIBRIUM-CONSTANT KHYD FOR THE HYDROLYSIS OF THE LYS15-ALA16 REACTIVE-SITE PEPTIDE-BOND IN BOVINE PANCREATIC TRYPSIN-INHIBITOR (APROTININ)”. JOURNAL OF PROTEIN CHEMISTRY 7 (5): 633-640.
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1988 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948524Beckmann, J, Mehlich, A, Wenzel, Herbert, and Tschesche, Harald. 1988. “Semisynthetic inhibitors of human leukocyte elastase and their protective effect on lung elastin degradation in vitro”. Adv Exp Med Biol 240: 107-114.
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1987 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1655390Tschesche, Harald, BECKMANN, J, MEHLICH, A, SCHNABEL, E, TRUSCHEIT, E, and Wenzel, Herbert. 1987. “SEMISYNTHETIC ENGINEERING OF PROTEINASE-INHIBITOR HOMOLOGS”. BIOCHIMICA ET BIOPHYSICA ACTA 913 (1): 97-101.
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1987 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1655547SCOTT, CF, Wenzel, Herbert, Tschesche, Harald, and COLMAN, RW. 1987. “KINETICS OF INHIBITION OF HUMAN-PLASMA KALLIKREIN BY A SITE-SPECIFIC MODIFIED INHIBITOR ARG15-APROTININ - EVALUATION USING A MICROPLATE SYSTEM AND COMPARISON WITH OTHER PROTEASES”. BLOOD 69 (5): 1431-1436.
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1987 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1654700SIEKMANN, J, Wenzel, Herbert, SCHRODER, W, SCHUTT, H, TRUSCHEIT, E, ARENS, A, RAUENBUSCH, E, CHAZIN, WJ, WUTHRICH, K, and Tschesche, Harald. 1987. “PYROGLUTAMYL-APROTININ, A NEW APROTININ HOMOLOG FROM BOVINE LUNGS - ISOLATION, PROPERTIES, SEQUENCE-ANALYSIS AND CHARACTERIZATION USING HYDROGEN NUCLEAR MAGNETIC-RESONANCE IN SOLUTION”. BIOLOGICAL CHEMISTRY HOPPE-SEYLER 368 (2): 1589-1596.
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1987 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1654832HANKOVSZKY, OH, HIDEG, K, VONGOLDAMMER, E, MATUSZAK, E, KOLKENBROCK, H, Tschesche, Harald, and Wenzel, Herbert. 1987. “NEW NITROXIDE REAGENTS FOR THE SELECTIVE SPIN-LABELING AT THE GUANIDINO MOIETY OF ARGININE RESIDUES IN PEPTIDES AND PROTEINS”. BIOCHIMICA ET BIOPHYSICA ACTA 916 (1): 152-155.
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1987 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1655347SCHWARZ, H, HINZ, HJ, MEHLICH, A, Tschesche, Harald, and Wenzel, Herbert. 1987. “STABILITY STUDIES ON DERIVATIVES OF THE BOVINE PANCREATIC TRYPSIN-INHIBITOR”. BIOCHEMISTRY 26 (12): 3544-3551.
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1984 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1658517BODE, W, WALTER, J, HUBER, R, Wenzel, Herbert, and Tschesche, Harald. 1984. “THE REFINED 2.2-A (0.22-NM) X-RAY CRYSTAL-STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOG OF BOVINE PANCREATIC TRYPSIN-INHIBITOR”. EUROPEAN JOURNAL OF BIOCHEMISTRY 144 (1): 185-190.
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1982 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1660972ENGELBRECHT, S, PIEPER, E, MACARTNEY, HW, RAUTENBERG, W, Wenzel, Herbert, and Tschesche, Harald. 1982. “SEPARATION OF THE HUMAN-LEUKOCYTE ENZYMES ALANINE AMINOPEPTIDASE, CATHEPSIN-G, COLLAGENASE, ELASTASE AND MYELOPEROXIDASE”. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 363 (1): 305-316.
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1982 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1660931Wenzel, Herbert, Tschesche, Harald, VONGOLDAMMER, E, and NETZELMANN, U. 1982. “COMPLEX-FORMATION OF GUANIDINATED BOVINE TRYPSIN-INHIBITOR (KUNITZ) WITH TRYPSIN, CHYMOTRYPSIN AND TRYPSINOGEN AS STUDIED BY THE SPIN-LABEL TECHNIQUE”. FEBS LETTERS 140 (1): 53-57.
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1982 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1660955BURKHARDT, H, MENNINGER, H, BERNER, W, Wenzel, Herbert, Tschesche, Harald, HOOS, R, and MIERAU, HD. 1982. “INHIBITION OF RHEUMATOID CARTILAGE DEGRADATION - A BIOMECHANICAL ASSAY FOR POTENTIAL ANTI-RHEUMATIC DRUGS”. AKTUELLE RHEUMATOLOGIE 7 (02): 60-62.
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1981 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1661716Wenzel, Herbert, and Tschesche, Harald. 1981. “CHEMICAL MUTATION BY AMINO-ACID EXCHANGE IN THE REACTIVE SITE OF A PROTEINASE-INHIBITOR AND ALTERATION OF ITS INHIBITOR SPECIFITY”. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH 20 (3): 295-296.
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1981 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1661674Wenzel, Herbert, and Tschesche, Harald. 1981. “CLEAVAGE OF PEPTIDE-4-NITROANILIDE SUBSTRATES WITH VARYING CHAIN-LENGTH BY HUMAN-LEUKOCYTE ELASTASE”. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 362 (6): 829-831.
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1980 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1662186Wenzel, Herbert, ENGELBRECHT, S, REICH, H, MONDRY, W, and Tschesche, Harald. 1980. “SYNTHESIS AND ANALYTICAL USE OF 3-CARBOXYPROPIONYL-ALANYL-ALANYL-VALINE-4-NITROANILIDE - A SPECIFIC SUBSTRATE FOR HUMAN-LEUKOCYTE ELASTASE”. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE 361 (2): 1413-1416.