49 Publikationen
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2987979Sun, M., Kaminsky, C. K., Deppe, P., Ilse, M. - B., Vaz, F. M., Plecko, B., Lübke, T., and Randolph, L. M. (2024). A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis. Genes & Diseases 11:101025.PUB | DOI
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2023 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2988232Smith, K., Haslund-Gourley, B. S., Aziz, P. V., Heithoff, D. M., Restagno, D., Fried, J. C., Ilse, M. - B., Bäumges, H., Mahan, M. J., Lübke, T., et al. (2023). Establishment of Blood Glycosidase Activities and their Excursions in Sepsis. Glycobiology 33, 1016.PUB | WoS
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981846Sun, M., Kaminsky, C. K., Deppe, P., Ilse, M. - B., Vaz, F. M., Plecko, B., Lübke, T., and Randolph, L. M. (2023). A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis. Genes & Diseases.PUB | DOI | PubMed | Europe PMC
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962857Linhorst, A., and Lübke, T. (2022). The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives. Cells 11:1592.PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
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2022 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2967253Smith, K., Haslund-Gourley, B. S., Aziz, P. V., Heithoff, D. M., Restagno, D., Fried, J. C., Ilse, M. - B., Bäumges, H., Mahan, M. J., Lübke, T., et al. (2022). Establishment of Blood Glycosidase Activities and their Excursions in Sepsis. Glycobiology 32, 1034-1035.PUB | WoS
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2965167Haslund-Gourley, B. S., Aziz, P. V., Heithoff, D. M., Restagno, D., Fried, J. C., Ilse, M. - B., Bäumges, H., Mahan, M. J., Lübke, T., and Marth, J. D. (2022). Establishment of blood glycosidase activities and their excursions in sepsis. PNAS Nexus 1:pgac113.PUB | DOI | PubMed | Europe PMC
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2021 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2961637Aziz, P. V., Lewis, B. J., Haslund-Gourley, B. S., Heithoff, D. M., Westman, J. S., Restagno, D., Fried, J. C., Ilse, M. - B., Lübke, T., and Marth, J. D. (2021). Excursions of blood glycosidase activities in the pathogenesis and prognosis of Sepsis. Glycobiology 31, 1700.PUB | DOI | WoS
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2960244Verheyen, S., Blatterer, J., Speicher, M. R., Bhavani, G. S. L., Boons, G. - J., Ilse, M. - B., Andrae, D., Sproß, J., Vaz, F. M., Kircher, S. G., et al. (2021). Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency. Journal of Medical Genetics:jmedgenet-2021-108061.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2956816Kowalewski, B., Lange, H., Galle, S., Dierks, T., Lübke, T., and Damme, M. (2021). Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG). Biochemical Journal.PUB | DOI | WoS | PubMed | Europe PMC
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2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2946513Aziz, P., Haslund-Gourley, B., Heithoff, D., Westman, J., Restagno, D., Lewis, B., Fried, J., Ilse, M. - B., Lübke, T., and Marth, J. (2020). “Altered glycosidase Activities at Physiological pH in the Pathogenesis of Sepsis” in FASEB JOURNAL, vol. 34, (Hoboken: Wiley).PUB | DOI | WoS
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948390Lübke, T., and Damme, M. (2020). Lysosomal sulfatases: a growing family*. Biochemical Journal 477, 3963-3983.PUB | DOI | WoS | PubMed | Europe PMC
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945876Trabszo, C., Ramms, B., Chopra, P., Lüllmann-Rauch, R., Stroobants, S., Sproß, J., Jeschke, A., Schinke, T., Boons, G. - J., Esko, J., et al. (2020). Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate. Biochemical Journal.PUB | DOI | WoS | PubMed | Europe PMC
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937243Korf-Klingebiel, M., Reboll, M. R., Grote, K., Schleiner, H., Wang, Y., Wu, X., Klede, S., Mikhed, Y., Bauersachs, J., Klintschar, M., et al. (2019). Heparan Sulfate-Editing Extracellular Sulfatases Enhance Vascular Endothelial Growth Factor Bioavailability for Ischemic Heart Repair. Circulation research 125, 787-801.PUB | DOI | WoS | PubMed | Europe PMC
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920271Stroobants, S., Wolf, H., Callaerts-Vegh, Z., Dierks, T., Lübke, T., and D'Hooge, R. (2018). Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 12:15.PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909150Pan, X., Wang, Y., Lübke, T., Hinek, A., and Pshezhetsky, A. V. (2017). Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings. PLoS One 12:e0172854.PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2908778Dhamale, O. P., Lawrence, R., Wiegmann, E., Shah, B. A., Al-Mafraji, K., Lamanna, W. C., Lübke, T., Dierks, T., Boons, G. - J., and Esko, J. D. (2017). Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase. ACS Chemical Biology 12, 367-373.PUB | DOI | WoS | PubMed | Europe PMC
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2905616Wolf, H., Damme, M., Stroobants, S., D'Hooge, R., Beck, H. C., Hermans-Borgmeyer, I., Lüllmann-Rauch, R., Dierks, T., and Lübke, T. (2016). A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. Disease Models & Mechanisms 9, 1015-1028.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2658538Kong, X. Y., Nesset, C. K., Damme, M., Loeberg, E. - M., Lübke, T., Maehlen, J., Andersson, K. B., Roos, N., Thoresen, G. H., Rustan, A. C., et al. (2014). Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells. Disease Models & Mechanisms 7, 351-362.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2672894Pan, X., Grigoryeva, L., Seyrantepe, V., Peng, J., Kollmann, K., Tremblay, J., Lavoie, J. L., Hinek, A., Lübke, T., and Pshezhetsky, A. V. (2014). Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1. PLoS genetics 10:e1004146.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699273Kowalewski, B., Lübke, T., Kollmann, K., Braulke, T., Reinheckel, T., Dierks, T., and Damme, M. (2014). Molecular Characterization of Arylsulfatase G: EXPRESSION, PROCESSING, GLYCOSYLATION, TRANSPORT, AND ACTIVITY. The Journal of biological chemistry 289, 27992-28005.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623550Wiegmann, E., Westendorf, E., Kalus, I., Pringle, T. H., Lübke, T., and Dierks, T. (2013). Arylsulfatase K, a Novel Lysosomal Sulfatase. Journal of Biological Chemistry 288, 30019-30028.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623533Milz, F., Harder, A., Neuhaus, P., Breitkreuz-Korff, O., Walhorn, V., Lübke, T., Anselmetti, D., and Dierks, T. (2013). Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate. Biochim Biophys Acta 1830, 5287-5298.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471754Makrypidi, G., Damme, M., Müller-Loennies, S., Trusch, M., Schmidt, B., Schlüter, H., Heeren, J., Lübke, T., Saftig, P., and Braulke, T. (2012). Mannose 6 dephosphorylation of lysosomal proteins mediated by Acid phosphatases acp2 and acp5. Molecular and cellular biology 32, 774-782.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2529586Kollmann, K., Damme, M., Markmann, S., Morelle, W., Schweizer, M., Hermans-Borgmeyer, I., Rochert, A. K., Pohl, S., Lübke, T., Michalski, J. - C., et al. (2012). Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice. Brain 135, 2661-2675.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2494022Kowalewski, B., Lamanna, W. C., Lawrence, R., Damme, M., Padva, M., Stroobants, S., Kalus, I., Frese, M. - A., Lübke, T., Lüllmann-Rauch, R., et al. (2012). Arylsulfatase G Inactivation Causes Loss of Heparan Sulfate 3-O-Sulfatase Activity and Mucopolysaccharidosis in Mice. Proc. Natl. Acad. Sci. USA 109, 10310-10315.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940515Damme, M., Stroobants, S., Walkley, S. U., Lüllmann-Rauch, R., D'Hooge, R., Fogh, J., Saftig, P., Lübke, T., and Blanz, J. (2011). Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in alpha-mannosidosis. Journal of Neuropathology & Experimental Neurology 70, 83-94.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2352585Savalas, L. R., Gasnier, B., Damme, M., Lübke, T., Wrocklage, C., Debacker, C., Jezeqou, A., Reinheckel, T., Hasilik, A., Saftig, P., et al. (2011). Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L. Biochemical Journal 436, 113-121.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939855Rosner, C., Kruse, P. H., Lübke, T., and Walter, L. (2010). Erratum to: Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics 62, 409-418.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2776186Rosner, C., Kruse, P. H., Lübke, T., and Walter, L. (2010). Rhesus macaque MHC class I molecules show differential subcellular localizations. Immunogenetics 62, 149-158.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939885Kollmann, K., Pohl, S., Marschner, K., Encarnacao, M., Sakwa, I., Tiede, S., Poorthuis, B. J., Lübke, T., Müller-Loennies, S., Storch, S., et al. (2010). Mannose phosphorylation in health and disease. European Journal of Cell Biology 89, 117-123.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902203Damme, M., Morelle, W., Schmidt, B., Andersson, C., Fogh, J., Michalski, J. - C., and Lübke, T. (2010). Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis. Molecular and Cellular Biology 30, 273-283.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939923Lakomek, K., Dickmanns, A., Kettwig, M., Urlaub, H., Ficner, R., and Lübke, T. (2009). Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography. BMC Structural Biology 9, 56-72.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902143Schieweck, O., Damme, M., Schröder, B., Hasilik, A., Schmidt, B., and Lübke, T. (2009). NCU-G1 is a highly glycosylated integral membrane protein of the lysosome. Biochemical Journal 422, 83-90.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939981Lübke, T., Lobel, P., and Sleat, D. E. (2009). Proteomics of the lysosome. Biochimica et Biophysica Acta 1793, 625-635.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940533Kollmann, K., Damme, M., Deuschl, F., Kahle, J., D'Hooge, R., Lüllmann-Rauch, R., and Lübke, T. (2009). Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1. Febs Journal 276, 1356-1369.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939939Lakomek, K., Dickmanns, A., Mueller, U., Kollmann, K., Deuschl, F., Berndt, A., Lübke, T., and Ficner, R. (2009). De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse. Acta Crystallographica Section D 65, 220-228.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939993Fedele, A. O., Filocamo, M., Di Rocco, M., Sersale, G., Lübke, T., di Natale, P., Cosma, M. P., and Ballabio, A. (2007). Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome). Human Mutation 28, 523.PUB | DOI
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2007 | Zeitschriftenaufsatz | PUB-ID: 1940006Hellbusch, C., Sperandio, M., Frommhold, D., Yakubenia, S., Wild, M. K., Popovici, D., Vestweber, D., Gröne, H. - J., von Figura, K., Lübke, T., et al. (2007). Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II. Journal of Biological Chemistry 282, 10762-10772.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940030Deuschl, F., Kollmann, K., von Figura, K., and Lübke, T. (2006). Molecular characterization of the hypothetical 66.3-kDa protein in mouse: lysosomal targeting, glycosylation, processing and tissue distribution. Febs Letters 580, 5747-5752.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940045Thiel, C., Lübke, T., Matthijs, G., von Figura, K., and Körner, C. (2006). Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality. Molecular and Cellular Biology 26, 5615-5620.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940057Tiede, S., Storch, S., Lübke, T., Henrissat, B., Bargal, R., Raas-Rothschild, A., and Braulke, T. (2006). Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase. Nature Medicine 11, 1109-1112.PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940072Kollmann, K., Mutenda, K. E., Balleininger, M., Eckermann, E., von Figura, K., Schmidt, B., and Lübke, T. (2005). Identification of novel lysosomal matrix proteins by proteome analysis. Proteomics 5, 3966-3978.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940085Hartmann, D., de Strooper, B., Serneels, L., Craessaerts, K., Herreman, A., Annaert, W., Umans, L., Lübke, T., Illert, A. L., von Figura, K., et al. (2002). The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Human Molecular Genetics 11, 2615-2624.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940103Hansske, B., Thiel, C., Lübke, T., Hasilik, M., Höning, S., Peters, V., Heidemann, P. H., Hoffmann, G. F., Berger, E. G., von Figura, K., et al. (2002). Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId. Journal of Clinical Investigation 109, 725-733.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940119Lübke, T., Marquardt, T., Etzioni, A., Hartmann, E., von Figura, K., and Körner, C. (2001). Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nature Genetics 28, 73-76.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Dissertation | PUB-ID: 1940291Lübke, T. (2001). Congenital Disorder of Glycosylation (CDG)-IIc: Eine retrovirale Expressionsklonierung identifiziert das CDG-IIc Syndrom (Leukozyten Adhäsionsdefekt II) als eine GDP-Fukose Transporter Defizienz. Göttingen, Deutschland: Elektronische Dissertation der Georg-August-Universität Göttingen.PUB
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940146Andersson, L. A., McNairn, E., Lübke, T., Pau, R. N., and Boxer, D. H. (2000). ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli. Journal of Bacteriology 182, 7035-7043.PUB | DOI | WoS | PubMed | Europe PMC
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940173Lübke, T., Marquardt, T., von Figura, K., and Körner, C. (1999). A new type of carbohydrate-deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi. Journal of Biological Chemistry 274, 25986-25989.PUB | DOI | WoS | PubMed | Europe PMC