48 Publikationen

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  • [48]
    2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2987979
    M. Sun, C. K. Kaminsky, P. Deppe, M. - B. Ilse, F. M. Vaz, B. Plecko, T. Lübke, and L. M. Randolph, “A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis”, Genes & Diseases, 2024, 11, : 101025.
    PUB | DOI
     
  • [47]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981846
    M. Sun, C. K. Kaminsky, P. Deppe, M. - B. Ilse, F. M. Vaz, B. Plecko, T. Lübke, and L. M. Randolph, “A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis”, Genes & Diseases, 2023.
    PUB | DOI | PubMed | Europe PMC
     
  • [46]
    2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962857 OA
    A. Linhorst, and T. Lübke, “The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives”, Cells, 2022, 11, : 1592.
    PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
     
  • [45]
    2022 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2967253
    K. Smith, B. S. Haslund-Gourley, P. V. Aziz, D. M. Heithoff, D. Restagno, J. C. Fried, M. - B. Ilse, H. Bäumges, M. J. Mahan, T. Lübke, et al., “Establishment of Blood Glycosidase Activities and their Excursions in Sepsis”, Glycobiology , 2022, 32, 1034-1035.
    PUB | WoS
     
  • [44]
    2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2965167
    B. S. Haslund-Gourley, P. V. Aziz, D. M. Heithoff, D. Restagno, J. C. Fried, M. - B. Ilse, H. Bäumges, M. J. Mahan, T. Lübke, and J. D. Marth, “Establishment of blood glycosidase activities and their excursions in sepsis”, PNAS Nexus, 2022, 1, : pgac113.
    PUB | DOI | PubMed | Europe PMC
     
  • [43]
    2021 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2961637
    P. V. Aziz, B. J. Lewis, B. S. Haslund-Gourley, D. M. Heithoff, J. S. Westman, D. Restagno, J. C. Fried, M. - B. Ilse, T. Lübke, and J. D. Marth, “Excursions of blood glycosidase activities in the pathogenesis and prognosis of Sepsis”, Glycobiology , 2021, 31, 1700.
    PUB | DOI | WoS
     
  • [42]
    2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2960244 OA
    S. Verheyen, J. Blatterer, M. R. Speicher, G. S. L. Bhavani, G. - J. Boons, M. - B. Ilse, D. Andrae, J. Sproß, F. M. Vaz, S. G. Kircher, et al., “Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency”, Journal of Medical Genetics, 2021, : jmedgenet-2021-108061.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [41]
    2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2956816
    B. Kowalewski, H. Lange, S. Galle, T. Dierks, T. Lübke, and M. Damme, “Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG)”, Biochemical Journal, 2021.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [40]
    2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2946513
    P. Aziz, B. Haslund-Gourley, D. Heithoff, J. Westman, D. Restagno, B. Lewis, J. Fried, M. - B. Ilse, T. Lübke, and J. Marth, in FASEB JOURNAL, Wiley, Hoboken, 2020.
    PUB | DOI | WoS
     
  • [39]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948390
    T. Lübke, and M. Damme, “Lysosomal sulfatases: a growing family*”, Biochemical Journal, 2020, 477, 3963-3983.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [38]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945876
    C. Trabszo, B. Ramms, P. Chopra, R. Lüllmann-Rauch, S. Stroobants, J. Sproß, A. Jeschke, T. Schinke, G. - J. Boons, J. Esko, et al., “Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate”, Biochemical Journal, 2020.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [37]
    2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937243
    M. Korf-Klingebiel, M. R. Reboll, K. Grote, H. Schleiner, Y. Wang, X. Wu, S. Klede, Y. Mikhed, J. Bauersachs, M. Klintschar, et al., “Heparan Sulfate-Editing Extracellular Sulfatases Enhance Vascular Endothelial Growth Factor Bioavailability for Ischemic Heart Repair”, Circulation research, 2019, 125, 787-801.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [36]
    2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920271
    S. Stroobants, H. Wolf, Z. Callaerts-Vegh, T. Dierks, T. Lübke, and R. D'Hooge, “Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice”, FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2018, 12, : 15.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [35]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909150
    X. Pan, Y. Wang, T. Lübke, A. Hinek, and A. V. Pshezhetsky, “Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings”, PLoS One, 2017, 12, : e0172854.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [34]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2908778
    O. P. Dhamale, R. Lawrence, E. Wiegmann, B. A. Shah, K. Al-Mafraji, W. C. Lamanna, T. Lübke, T. Dierks, G. - J. Boons, and J. D. Esko, “Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase”, ACS Chemical Biology, 2017, 12, 367-373.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [33]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2905616 OA
    H. Wolf, M. Damme, S. Stroobants, R. D'Hooge, H. C. Beck, I. Hermans-Borgmeyer, R. Lüllmann-Rauch, T. Dierks, and T. Lübke, “A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease”, Disease Models & Mechanisms, 2016, 9, 1015-1028.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [32]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2658538 OA
    X. Y. Kong, C. K. Nesset, M. Damme, E. - M. Loeberg, T. Lübke, J. Maehlen, K. B. Andersson, N. Roos, G. H. Thoresen, A. C. Rustan, et al., “Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells”, Disease Models & Mechanisms, 2014, 7, 351-362.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [31]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2672894 OA
    X. Pan, L. Grigoryeva, V. Seyrantepe, J. Peng, K. Kollmann, J. Tremblay, J. L. Lavoie, A. Hinek, T. Lübke, and A. V. Pshezhetsky, “Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1”, PLoS genetics, 2014, 10, : e1004146.
    PUB | PDF | DOI | WoS | PubMed | Europe PMC
     
  • [30]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699273
    B. Kowalewski, T. Lübke, K. Kollmann, T. Braulke, T. Reinheckel, T. Dierks, and M. Damme, “Molecular Characterization of Arylsulfatase G: EXPRESSION, PROCESSING, GLYCOSYLATION, TRANSPORT, AND ACTIVITY”, The Journal of biological chemistry, 2014, 289, 27992-28005.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [29]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623550
    E. Wiegmann, E. Westendorf, I. Kalus, T. H. Pringle, T. Lübke, and T. Dierks, “Arylsulfatase K, a Novel Lysosomal Sulfatase”, Journal of Biological Chemistry, 2013, 288, 30019-30028.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [28]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623533
    F. Milz, A. Harder, P. Neuhaus, O. Breitkreuz-Korff, V. Walhorn, T. Lübke, D. Anselmetti, and T. Dierks, “Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate”, Biochim Biophys Acta, 2013, 1830, 5287-5298.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [27]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471754
    G. Makrypidi, M. Damme, S. Müller-Loennies, M. Trusch, B. Schmidt, H. Schlüter, J. Heeren, T. Lübke, P. Saftig, and T. Braulke, “Mannose 6 dephosphorylation of lysosomal proteins mediated by Acid phosphatases acp2 and acp5”, Molecular and cellular biology, 2012, 32, 774-782.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [26]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2529586
    K. Kollmann, M. Damme, S. Markmann, W. Morelle, M. Schweizer, I. Hermans-Borgmeyer, A. K. Rochert, S. Pohl, T. Lübke, J. - C. Michalski, et al., “Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice”, Brain, 2012, 135, 2661-2675.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [25]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2494022
    B. Kowalewski, W. C. Lamanna, R. Lawrence, M. Damme, M. Padva, S. Stroobants, I. Kalus, M. - A. Frese, T. Lübke, R. Lüllmann-Rauch, et al., “Arylsulfatase G Inactivation Causes Loss of Heparan Sulfate 3-O-Sulfatase Activity and Mucopolysaccharidosis in Mice”, Proc. Natl. Acad. Sci. USA, 2012, 109, 10310-10315.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [24]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940515
    M. Damme, S. Stroobants, S. U. Walkley, R. Lüllmann-Rauch, R. D'Hooge, J. Fogh, P. Saftig, T. Lübke, and J. Blanz, “Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in alpha-mannosidosis”, Journal of Neuropathology & Experimental Neurology, 2011, 70, 83-94.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [23]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2352585
    L. R. Savalas, B. Gasnier, M. Damme, T. Lübke, C. Wrocklage, C. Debacker, A. Jezeqou, T. Reinheckel, A. Hasilik, P. Saftig, et al., “Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.”, Biochemical Journal, 2011, 436, 113-121.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [22]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939855
    C. Rosner, P. H. Kruse, T. Lübke, and L. Walter, “Erratum to: Rhesus macaque MHC class I molecules show differential subcellular localizations”, Immunogenetics, 2010, 62, 409-418.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [21]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2776186
    C. Rosner, P. H. Kruse, T. Lübke, and L. Walter, “Rhesus macaque MHC class I molecules show differential subcellular localizations”, Immunogenetics, 2010, 62, 149-158.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [20]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939885
    K. Kollmann, S. Pohl, K. Marschner, M. Encarnacao, I. Sakwa, S. Tiede, B. J. Poorthuis, T. Lübke, S. Müller-Loennies, S. Storch, et al., “Mannose phosphorylation in health and disease”, European Journal of Cell Biology, 2010, 89, 117-123.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [19]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902203
    M. Damme, W. Morelle, B. Schmidt, C. Andersson, J. Fogh, J. - C. Michalski, and T. Lübke, “Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.”, Molecular and Cellular Biology, 2010, 30, 273-283.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [18]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939923
    K. Lakomek, A. Dickmanns, M. Kettwig, H. Urlaub, R. Ficner, and T. Lübke, “Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography”, BMC Structural Biology, 2009, 9, 56-72.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [17]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902143
    O. Schieweck, M. Damme, B. Schröder, A. Hasilik, B. Schmidt, and T. Lübke, “NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.”, Biochemical Journal, 2009, 422, 83-90.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [16]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939981
    T. Lübke, P. Lobel, and D. E. Sleat, “Proteomics of the lysosome”, Biochimica et Biophysica Acta, 2009, 1793, 625-635.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [15]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940533
    K. Kollmann, M. Damme, F. Deuschl, J. Kahle, R. D'Hooge, R. Lüllmann-Rauch, and T. Lübke, “Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1”, Febs Journal, 2009, 276, 1356-1369.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [14]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939939
    K. Lakomek, A. Dickmanns, U. Mueller, K. Kollmann, F. Deuschl, A. Berndt, T. Lübke, and R. Ficner, “De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse”, Acta Crystallographica Section D, 2009, 65, 220-228.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [13]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939993
    A. O. Fedele, M. Filocamo, M. Di Rocco, G. Sersale, T. Lübke, P. di Natale, M. P. Cosma, and A. Ballabio, “Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome)”, Human Mutation, 2007, 28, 523.
    PUB | DOI
     
  • [12]
    2007 | Zeitschriftenaufsatz | PUB-ID: 1940006
    C. Hellbusch, M. Sperandio, D. Frommhold, S. Yakubenia, M. K. Wild, D. Popovici, D. Vestweber, H. - J. Gröne, K. von Figura, T. Lübke, et al., “Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II”, Journal of Biological Chemistry, 2007, 282, 10762-10772.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [11]
    2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940030
    F. Deuschl, K. Kollmann, K. von Figura, and T. Lübke, “Molecular characterization of the hypothetical 66.3-kDa protein in mouse: lysosomal targeting, glycosylation, processing and tissue distribution”, Febs Letters, 2006, 580, 5747-5752.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [10]
    2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940045
    C. Thiel, T. Lübke, G. Matthijs, K. von Figura, and C. Körner, “Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality”, Molecular and Cellular Biology, 2006, 26, 5615-5620.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [9]
    2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940057
    S. Tiede, S. Storch, T. Lübke, B. Henrissat, R. Bargal, A. Raas-Rothschild, and T. Braulke, “Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase”, Nature Medicine, 2006, 11, 1109-1112.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [8]
    2005 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 1940182
    T. Lübke, and J. Landgrebe, in Lysosomes (Ed.: P. Saftig), Landes Bioscience, Georgetown, Texas, USA, 2005, p. 130-143.
    PUB | DOI
     
  • [7]
    2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940072
    K. Kollmann, K. E. Mutenda, M. Balleininger, E. Eckermann, K. von Figura, B. Schmidt, and T. Lübke, “Identification of novel lysosomal matrix proteins by proteome analysis”, Proteomics, 2005, 5, 3966-3978.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [6]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940085
    D. Hartmann, B. de Strooper, L. Serneels, K. Craessaerts, A. Herreman, W. Annaert, L. Umans, T. Lübke, A. L. Illert, K. von Figura, et al., “The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts”, Human Molecular Genetics, 2002, 11, 2615-2624.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [5]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940103
    B. Hansske, C. Thiel, T. Lübke, M. Hasilik, S. Höning, V. Peters, P. H. Heidemann, G. F. Hoffmann, E. G. Berger, K. von Figura, et al., “Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId”, Journal of Clinical Investigation, 2002, 109, 725-733.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [4]
    2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940119
    T. Lübke, T. Marquardt, A. Etzioni, E. Hartmann, K. von Figura, and C. Körner, “Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency”, Nature Genetics, 2001, 28, 73-76.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [3]
    2001 | Dissertation | PUB-ID: 1940291
    T. Lübke, Congenital Disorder of Glycosylation (CDG)-IIc: Eine retrovirale Expressionsklonierung identifiziert das CDG-IIc Syndrom (Leukozyten Adhäsionsdefekt II) als eine GDP-Fukose Transporter Defizienz, Elektronische Dissertation Der Georg-August-Universität Göttingen, Göttingen, Deutschland, 2001.
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  • [2]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940146
    L. A. Andersson, E. McNairn, T. Lübke, R. N. Pau, and D. H. Boxer, “ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli”, Journal of Bacteriology, 2000, 182, 7035-7043.
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  • [1]
    1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940173
    T. Lübke, T. Marquardt, K. von Figura, and C. Körner, “A new type of carbohydrate-deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi”, Journal of Biological Chemistry, 1999, 274, 25986-25989.
    PUB | DOI | WoS | PubMed | Europe PMC
     

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