48 Publikationen
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2024 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2987979M. Sun, C. K. Kaminsky, P. Deppe, M. - B. Ilse, F. M. Vaz, B. Plecko, T. Lübke, and L. M. Randolph, “A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis”, Genes & Diseases, 2024, 11, : 101025.PUB | DOI
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2981846M. Sun, C. K. Kaminsky, P. Deppe, M. - B. Ilse, F. M. Vaz, B. Plecko, T. Lübke, and L. M. Randolph, “A novel homozygous missense variant in ARSK causes MPS X, a new subtype of mucopolysaccharidosis”, Genes & Diseases, 2023.PUB | DOI | PubMed | Europe PMC
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2962857A. Linhorst, and T. Lübke, “The Human Ntn-Hydrolase Superfamily: Structure, Functions and Perspectives”, Cells, 2022, 11, : 1592.PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
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2022 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2967253K. Smith, B. S. Haslund-Gourley, P. V. Aziz, D. M. Heithoff, D. Restagno, J. C. Fried, M. - B. Ilse, H. Bäumges, M. J. Mahan, T. Lübke, et al., “Establishment of Blood Glycosidase Activities and their Excursions in Sepsis”, Glycobiology , 2022, 32, 1034-1035.PUB | WoS
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2965167B. S. Haslund-Gourley, P. V. Aziz, D. M. Heithoff, D. Restagno, J. C. Fried, M. - B. Ilse, H. Bäumges, M. J. Mahan, T. Lübke, and J. D. Marth, “Establishment of blood glycosidase activities and their excursions in sepsis”, PNAS Nexus, 2022, 1, : pgac113.PUB | DOI | PubMed | Europe PMC
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2021 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2961637P. V. Aziz, B. J. Lewis, B. S. Haslund-Gourley, D. M. Heithoff, J. S. Westman, D. Restagno, J. C. Fried, M. - B. Ilse, T. Lübke, and J. D. Marth, “Excursions of blood glycosidase activities in the pathogenesis and prognosis of Sepsis”, Glycobiology , 2021, 31, 1700.PUB | DOI | WoS
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2960244S. Verheyen, J. Blatterer, M. R. Speicher, G. S. L. Bhavani, G. - J. Boons, M. - B. Ilse, D. Andrae, J. Sproß, F. M. Vaz, S. G. Kircher, et al., “Novel subtype of mucopolysaccharidosis caused by arylsulfatase K (ARSK) deficiency”, Journal of Medical Genetics, 2021, : jmedgenet-2021-108061.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2956816B. Kowalewski, H. Lange, S. Galle, T. Dierks, T. Lübke, and M. Damme, “Decoding the consecutive lysosomal degradation of 3-O-sulfate containing heparan sulfate by Arylsulfatase G (ARSG)”, Biochemical Journal, 2021.PUB | DOI | WoS | PubMed | Europe PMC
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948390T. Lübke, and M. Damme, “Lysosomal sulfatases: a growing family*”, Biochemical Journal, 2020, 477, 3963-3983.PUB | DOI | WoS | PubMed | Europe PMC
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945876C. Trabszo, B. Ramms, P. Chopra, R. Lüllmann-Rauch, S. Stroobants, J. Sproß, A. Jeschke, T. Schinke, G. - J. Boons, J. Esko, et al., “Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate”, Biochemical Journal, 2020.PUB | DOI | WoS | PubMed | Europe PMC
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937243M. Korf-Klingebiel, M. R. Reboll, K. Grote, H. Schleiner, Y. Wang, X. Wu, S. Klede, Y. Mikhed, J. Bauersachs, M. Klintschar, et al., “Heparan Sulfate-Editing Extracellular Sulfatases Enhance Vascular Endothelial Growth Factor Bioavailability for Ischemic Heart Repair”, Circulation research, 2019, 125, 787-801.PUB | DOI | WoS | PubMed | Europe PMC
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2018 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2920271S. Stroobants, H. Wolf, Z. Callaerts-Vegh, T. Dierks, T. Lübke, and R. D'Hooge, “Sensorimotor and Neurocognitive Dysfunctions Parallel Early Telencephalic Neuropathology in Fucosidosis Mice”, FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2018, 12, : 15.PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2909150X. Pan, Y. Wang, T. Lübke, A. Hinek, and A. V. Pshezhetsky, “Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings”, PLoS One, 2017, 12, : e0172854.PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2908778O. P. Dhamale, R. Lawrence, E. Wiegmann, B. A. Shah, K. Al-Mafraji, W. C. Lamanna, T. Lübke, T. Dierks, G. - J. Boons, and J. D. Esko, “Arylsulfatase K is the Lysosomal 2-Sulfoglucuronate Sulfatase”, ACS Chemical Biology, 2017, 12, 367-373.PUB | DOI | WoS | PubMed | Europe PMC
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2905616H. Wolf, M. Damme, S. Stroobants, R. D'Hooge, H. C. Beck, I. Hermans-Borgmeyer, R. Lüllmann-Rauch, T. Dierks, and T. Lübke, “A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease”, Disease Models & Mechanisms, 2016, 9, 1015-1028.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2658538X. Y. Kong, C. K. Nesset, M. Damme, E. - M. Loeberg, T. Lübke, J. Maehlen, K. B. Andersson, N. Roos, G. H. Thoresen, A. C. Rustan, et al., “Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells”, Disease Models & Mechanisms, 2014, 7, 351-362.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2672894X. Pan, L. Grigoryeva, V. Seyrantepe, J. Peng, K. Kollmann, J. Tremblay, J. L. Lavoie, A. Hinek, T. Lübke, and A. V. Pshezhetsky, “Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1”, PLoS genetics, 2014, 10, : e1004146.PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2699273B. Kowalewski, T. Lübke, K. Kollmann, T. Braulke, T. Reinheckel, T. Dierks, and M. Damme, “Molecular Characterization of Arylsulfatase G: EXPRESSION, PROCESSING, GLYCOSYLATION, TRANSPORT, AND ACTIVITY”, The Journal of biological chemistry, 2014, 289, 27992-28005.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623550E. Wiegmann, E. Westendorf, I. Kalus, T. H. Pringle, T. Lübke, and T. Dierks, “Arylsulfatase K, a Novel Lysosomal Sulfatase”, Journal of Biological Chemistry, 2013, 288, 30019-30028.PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2623533F. Milz, A. Harder, P. Neuhaus, O. Breitkreuz-Korff, V. Walhorn, T. Lübke, D. Anselmetti, and T. Dierks, “Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate”, Biochim Biophys Acta, 2013, 1830, 5287-5298.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2471754G. Makrypidi, M. Damme, S. Müller-Loennies, M. Trusch, B. Schmidt, H. Schlüter, J. Heeren, T. Lübke, P. Saftig, and T. Braulke, “Mannose 6 dephosphorylation of lysosomal proteins mediated by Acid phosphatases acp2 and acp5”, Molecular and cellular biology, 2012, 32, 774-782.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2529586K. Kollmann, M. Damme, S. Markmann, W. Morelle, M. Schweizer, I. Hermans-Borgmeyer, A. K. Rochert, S. Pohl, T. Lübke, J. - C. Michalski, et al., “Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice”, Brain, 2012, 135, 2661-2675.PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2494022B. Kowalewski, W. C. Lamanna, R. Lawrence, M. Damme, M. Padva, S. Stroobants, I. Kalus, M. - A. Frese, T. Lübke, R. Lüllmann-Rauch, et al., “Arylsulfatase G Inactivation Causes Loss of Heparan Sulfate 3-O-Sulfatase Activity and Mucopolysaccharidosis in Mice”, Proc. Natl. Acad. Sci. USA, 2012, 109, 10310-10315.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940515M. Damme, S. Stroobants, S. U. Walkley, R. Lüllmann-Rauch, R. D'Hooge, J. Fogh, P. Saftig, T. Lübke, and J. Blanz, “Cerebellar alterations and gait defects as therapeutic outcome measures for enzyme replacement therapy in alpha-mannosidosis”, Journal of Neuropathology & Experimental Neurology, 2011, 70, 83-94.PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2352585L. R. Savalas, B. Gasnier, M. Damme, T. Lübke, C. Wrocklage, C. Debacker, A. Jezeqou, T. Reinheckel, A. Hasilik, P. Saftig, et al., “Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.”, Biochemical Journal, 2011, 436, 113-121.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939855C. Rosner, P. H. Kruse, T. Lübke, and L. Walter, “Erratum to: Rhesus macaque MHC class I molecules show differential subcellular localizations”, Immunogenetics, 2010, 62, 409-418.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2776186C. Rosner, P. H. Kruse, T. Lübke, and L. Walter, “Rhesus macaque MHC class I molecules show differential subcellular localizations”, Immunogenetics, 2010, 62, 149-158.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939885K. Kollmann, S. Pohl, K. Marschner, M. Encarnacao, I. Sakwa, S. Tiede, B. J. Poorthuis, T. Lübke, S. Müller-Loennies, S. Storch, et al., “Mannose phosphorylation in health and disease”, European Journal of Cell Biology, 2010, 89, 117-123.PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902203M. Damme, W. Morelle, B. Schmidt, C. Andersson, J. Fogh, J. - C. Michalski, and T. Lübke, “Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.”, Molecular and Cellular Biology, 2010, 30, 273-283.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939923K. Lakomek, A. Dickmanns, M. Kettwig, H. Urlaub, R. Ficner, and T. Lübke, “Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography”, BMC Structural Biology, 2009, 9, 56-72.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1902143O. Schieweck, M. Damme, B. Schröder, A. Hasilik, B. Schmidt, and T. Lübke, “NCU-G1 is a highly glycosylated integral membrane protein of the lysosome.”, Biochemical Journal, 2009, 422, 83-90.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939981T. Lübke, P. Lobel, and D. E. Sleat, “Proteomics of the lysosome”, Biochimica et Biophysica Acta, 2009, 1793, 625-635.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940533K. Kollmann, M. Damme, F. Deuschl, J. Kahle, R. D'Hooge, R. Lüllmann-Rauch, and T. Lübke, “Molecular characterization and gene disruption of mouse lysosomal putative serine carboxypeptidase 1”, Febs Journal, 2009, 276, 1356-1369.PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939939K. Lakomek, A. Dickmanns, U. Mueller, K. Kollmann, F. Deuschl, A. Berndt, T. Lübke, and R. Ficner, “De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse”, Acta Crystallographica Section D, 2009, 65, 220-228.PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1939993A. O. Fedele, M. Filocamo, M. Di Rocco, G. Sersale, T. Lübke, P. di Natale, M. P. Cosma, and A. Ballabio, “Mutational analysis of the HGSNAT gene in Italian patients with mucopolysaccharidosis IIIC (Sanfilippo C syndrome)”, Human Mutation, 2007, 28, 523.PUB | DOI
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2007 | Zeitschriftenaufsatz | PUB-ID: 1940006C. Hellbusch, M. Sperandio, D. Frommhold, S. Yakubenia, M. K. Wild, D. Popovici, D. Vestweber, H. - J. Gröne, K. von Figura, T. Lübke, et al., “Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency II”, Journal of Biological Chemistry, 2007, 282, 10762-10772.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940030F. Deuschl, K. Kollmann, K. von Figura, and T. Lübke, “Molecular characterization of the hypothetical 66.3-kDa protein in mouse: lysosomal targeting, glycosylation, processing and tissue distribution”, Febs Letters, 2006, 580, 5747-5752.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940045C. Thiel, T. Lübke, G. Matthijs, K. von Figura, and C. Körner, “Targeted disruption of the mouse phosphomannomutase 2 gene causes early embryonic lethality”, Molecular and Cellular Biology, 2006, 26, 5615-5620.PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940057S. Tiede, S. Storch, T. Lübke, B. Henrissat, R. Bargal, A. Raas-Rothschild, and T. Braulke, “Mucolipidosis II is caused by mutations in GNPTA encoding the alpha/beta GlcNAc-1-phosphotransferase”, Nature Medicine, 2006, 11, 1109-1112.PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940072K. Kollmann, K. E. Mutenda, M. Balleininger, E. Eckermann, K. von Figura, B. Schmidt, and T. Lübke, “Identification of novel lysosomal matrix proteins by proteome analysis”, Proteomics, 2005, 5, 3966-3978.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940085D. Hartmann, B. de Strooper, L. Serneels, K. Craessaerts, A. Herreman, W. Annaert, L. Umans, T. Lübke, A. L. Illert, K. von Figura, et al., “The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts”, Human Molecular Genetics, 2002, 11, 2615-2624.PUB | DOI | WoS | PubMed | Europe PMC
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940103B. Hansske, C. Thiel, T. Lübke, M. Hasilik, S. Höning, V. Peters, P. H. Heidemann, G. F. Hoffmann, E. G. Berger, K. von Figura, et al., “Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId”, Journal of Clinical Investigation, 2002, 109, 725-733.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940119T. Lübke, T. Marquardt, A. Etzioni, E. Hartmann, K. von Figura, and C. Körner, “Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency”, Nature Genetics, 2001, 28, 73-76.PUB | DOI | WoS | PubMed | Europe PMC
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2001 | Dissertation | PUB-ID: 1940291T. Lübke, Congenital Disorder of Glycosylation (CDG)-IIc: Eine retrovirale Expressionsklonierung identifiziert das CDG-IIc Syndrom (Leukozyten Adhäsionsdefekt II) als eine GDP-Fukose Transporter Defizienz, Elektronische Dissertation Der Georg-August-Universität Göttingen, Göttingen, Deutschland, 2001.PUB
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940146L. A. Andersson, E. McNairn, T. Lübke, R. N. Pau, and D. H. Boxer, “ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli”, Journal of Bacteriology, 2000, 182, 7035-7043.PUB | DOI | WoS | PubMed | Europe PMC
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1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1940173T. Lübke, T. Marquardt, K. von Figura, and C. Körner, “A new type of carbohydrate-deficient glycoprotein syndrome due to a decreased import of GDP-fucose into the golgi”, Journal of Biological Chemistry, 1999, 274, 25986-25989.PUB | DOI | WoS | PubMed | Europe PMC