100 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2979009Klimpel, M., Terrao, M., Ching, N., Climenti, V., Noll, T., Pirzas, V., Laux, H.: Development of a perfusion process for continuous lentivirus production using stable suspension producer cell lines. Biotechnology and Bioengineering. (2023).PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2963556Romanova, N., Schmitz, J., Strakeljahn, M., Grünberger, A., Bahnemann, J., Noll, T.: Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response. Cells. 11, : 1763 (2022).PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2966624Hertel, O., Neuss, A., Busche, T., Brandt, D., Kalinowski, J., Bahnemann, J., Noll, T.: Enhancing stability of recombinant CHO cells by CRISPR/Cas9-mediated site-specific integration into regions with distinct histone modifications. Frontiers in Bioengineering and Biotechnology. 10, (2022).PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952449Witte, K.E., Hertel, O., Windmöller, B.A., Helweg, L., Höving, A.L., Knabbe, C., Busche, T., Greiner, J., Kalinowski, J., Noll, T., Mertzlufft, F., Beshay, M., Pfitzenmaier, J., Kaltschmidt, B., Kaltschmidt, C., Banz-Jansen, C., Simonis, M.: Nanopore Sequencing Reveals Global Transcriptome Signatures of Mitochondrial and Ribosomal Gene Expressions in Various Human Cancer Stem-like Cell Populations. Cancers. 13, : 1136 (2021).PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2954736Keysberg, C., Hertel, O., Schelletter, L., Busche, T., Sochart, C., Kalinowski, J., Hoffrogge, R., Otte, K., Noll, T.: Exploring the molecular content of CHO exosomes during bioprocessing. Applied Microbiology and Biotechnology. 105, 3673-3689 (2021).PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2955090Schmitz, J., Hertel, O., Yermakov, B., Noll, T., Grünberger, A.: Growth and eGFP-production of CHO-K1 suspension cells cultivated from single-cell to laboratory scale. Frontiers in Bioengineering and Biotechnology. 9, : 716343 (2021).PUB | PDF | DOI | WoS | PubMed | Europe PMC | Preprint
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2953580Budde, D., Albano, G.-L., Noll, T., Jurkiewicz, E.: Interaction of leachable model compounds and their impact on Chinese hamster ovary cell cultivation. Biotechnology Progress. : e3150 (2021).PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952639Romanova, N., Niemann, T., Greiner, J., Kaltschmidt, B., Kaltschmidt, C., Noll, T.: Hyperosmolality in CHO Culture: Effects on cellular behavior and morphology. Biotechnology and Bioengineering. 118, 2348-2359 (2021).PUB | PDF | DOI | Download (ext.) | WoS | PubMed | Europe PMC
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949089Schmitz, J., Täuber, S., Westerwalbesloh, C., von Lieres, E., Noll, T., Grünberger, A.: Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution. Biotechnology and Bioengineering. 118, 992-1005 (2021).PUB | Dateien verfügbar | DOI | WoS | PubMed | Europe PMC | Preprint
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944311Schelletter, L., Hertel, O., Antar, S.J., Scherling, C., Lattig, J., Noll, T., Hoffrogge, R.: A Positive Pressure Workstation for Semi Automated Peptide Purification of Complex Proteomic Samples. Rapid communications in mass spectrometry. 35, : e8873 (2020).PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948753Beatson, R., Graham, R., Grundland Freile, F., Cozzetto, D., Kannambath, S., Pfeifer, E., Woodman, N., Owen, J., Nuamah, R., Mandel, U., Pinder, S., Gillett, C., Noll, T., Bouybayoune, I., Taylor-Papadimitriou, J., Burchell, J.M.: Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype. Communications biology. 3, : 644 (2020).PUB | DOI | WoS | PubMed | Europe PMC
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2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945942Pries, A., Brachtvogel, L., Noll, T., Hoffrogge, R.: Impact of NaBu and RA on histones and nuclear signaling in CHO cells. BMC Proceedings. 14, : P-159 (2020).PUB
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2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945943Schelletter, L., Noll, T., Hoffrogge, R.: Media supplement induced signaling in CHO cells via triple SILAC-MS. BMC Proceedings. 14, : P-565 (2020).PUB
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945107Coronel, J., Gränicher, G., Sandig, V., Noll, T., Genzel, Y., Reichl, U.: Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion Mode. Frontiers in Bioengineering and Biotechnology. 8, : 672 (2020).PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944324Budde, D., Maier, T.V., Jurkiewicz, E., Pahl, I., Hauk, A., Tauscher, E., Gorls, H., Noll, T., Menzel, R.: Identification and evaluation of cell- growth-inhibiting bDtBPP-analogue degradation products from phosphite antioxidants used in polyolefin bioprocessing materials. Analytical and bioanalytical chemistry. 412, 4505-4518 (2020).PUB | DOI | WoS | PubMed | Europe PMC
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936490Seeger, B., Mentz, A., Knebel, C., Schmidt, F., Bednarz, H., Niehaus, K., Albaum, S., Kalinowski, J., Noll, T., Steinberg, P., Marx-Stoelting, P., Heise, T.: Assessment of mixture toxicity of (tri)azoles and their hepatotoxic effects in vitro by means of omics technologies. Archives of toxicology. 93, 2321-2333 (2019).PUB | DOI | WoS | PubMed | Europe PMC
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934600Krattenmacher, F., Heermann, T., Calvet, A., Krawczyk, B., Noll, T.: Effect of manufacturing temperature and storage duration on stability of chemically defined media measured with LC-MS/MS. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY. 94, 1144-1155 (2019).PUB | DOI | WoS
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2938369Coronel, J., Heinrich, C., Klausing, S., Noll, T., Figueredo-Cardero, A., Castilho, L.R.: Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production. Biotechnology progress. 36, e2915 (2019).PUB | DOI | WoS | PubMed | Europe PMC
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937250Schelletter, L., Albaum, S., Walter, S., Noll, T., Hoffrogge, R.: Clonal variations in CHO IGF signaling investigated by SILAC-based phosphoproteomics and LFQ-MS. Applied microbiology and biotechnology. 103, 8127-8143 (2019).PUB | DOI | WoS | PubMed | Europe PMC
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933358Schmitz, J., Noll, T., Grünberger, A.: Heterogeneity Studies of Mammalian Cells for Bioproduction. From Tools to Application. Trends in Biotechnology. 37, 645-660 (2019).PUB | DOI | WoS | PubMed | Europe PMC
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2018 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945946Brachtvogel, L., Walter, S., Noll, T., Hoffrogge, R.: MS-SILAC approach for phosphoproteomics of IGF signaling in producer CHO cells. BMC Proceedings. 12, : 3 (2018).PUB
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2018 | Konferenzbeitrag | PUB-ID: 2933363Schmitz, J., Noll, T., Grünberger, A.: Towards Microfluidic Single-Cell Cultivation of Mammalian Cell Lines. Presented at the Young Scientist Cell Culture Biotechnology Retreat, Laupheim (2018).PUB
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2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933359Schmitz, J., Kerkhoff, Y., Noll, T., Kohlheyer, D., Grünberger, A.: Towards dynamic single-cell cultivation systems for industrially relevant mammalian cell lines. Presented at the BioProcessing Days 2018, Recklinghausen (2018).PUB
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2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933362Schmitz, J., Kerkhoff, Y., Noll, T., Grünberger, A.: Dynamic microfluidical single-cell cultivation of mammalian cell lines. From experiment to analysis. Presented at the CeBiTec Symposium 2018, Bielefeld (2018).PUB
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2915619Romanova, N., Noll, T.: Engineered and Natural Promoters and Chromatin-Modifying Elements for Recombinant Protein Expression in CHO Cells. Biotechnology Journal. 13, : e1700232 (2017).PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2911396Müller, B., Heinrich, C., Jabs, W., Kaspar-Schönefeld, S., Schmidt, A., Wehmeier, N., Albaum, S., Baessmann, C., Noll, T., Hoffrogge, R.: Label-free protein quantification of sodium butyrate treated CHO cells by ESI-UHR-TOF-MS. Journal of Biotechnology. 257, 87-98 (2017).PUB | DOI | WoS | PubMed | Europe PMC
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2914045Wippermann, A., Noll, T.: DNA methylation in CHO cells. Journal of Biotechnology. 258, 206-210 (2017).PUB | DOI | WoS | PubMed | Europe PMC
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906640Coronel, J., Klausing, S., Heinrich, C., Noll, T., Figueredo-Cardero, A., Castilho, L.R.: Valeric acid supplementation combined to mild hypothermia increases productivity in CHO cell cultivations. Biochemical Engineering Journal. 114, 101-109 (2016).PUB | DOI | WoS
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907079Wippermann, A., Rupp, O., Brinkrolf, K., Hoffrogge, R., Noll, T.: Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology. 257, 150-161 (2016).PUB | DOI | WoS | PubMed | Europe PMC
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906641Beatson, R., Tajadura-Ortega, V., Achkova, D., Picco, G., Tsourouktsoglou, T.-D., Klausing, S., Hillier, M., Maher, J., Noll, T., Crocker, P.R., Taylor-Papadimitriou, J., Burchell, J.M.: The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nature Immunology. 17, 1273-1281 (2016).PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718767Wingens, M., Gätgens, J., Schmidt, A., Albaum, S., Büntemeyer, H., Noll, T., Hoffrogge, R.: 2D-DIGE screening of high-productive CHO cells under glucose limitation — Basic changes in the proteome equipment and hints for epigenetic effects. Journal of Biotechnology. 201, 86-97 (2015).PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718773Wippermann, A., Rupp, O., Brinkrolf, K., Hoffrogge, R., Noll, T.: The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells. Journal of Biotechnology. 199, 38-46 (2015).PUB | DOI | WoS | PubMed | Europe PMC
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2015 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2902782Knebel, C., Marx-Stoelting, P., Pfeil, R., Seeger, B., Steinberg, P., Mentz, A., Bednarz, H., Niehaus, K., Kalinowski, J., Noll, T., Heise, T.: Multi-level omics analysis of combination effects of (tri-)azoles in a set of different cell lines. Toxicology Letters. 238, S355 (2015).PUB | DOI | WoS
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656819Wippermann, A., Klausing, S., Rupp, O., Albaum, S., Büntemeyer, H., Noll, T., Hoffrogge, R.: Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells. Applied Microbiology and Biotechnology. 98, 579-589 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2694187Brinkrolf, K., Hoffrogge, R., Hackl, M., Tauch, A., Baumann, M., Noll, T., Goesmann, A., Pühler, A., Borth, N.: Functional -Omics for Cell Lines and Processes - The -Omics Technologies on the Example of CHO Cells. In: Hauser, H. and Wagner, R. (eds.) Animal Cell Biotechnology In Biologics Production. p. 702. Walter de Gruyter, Berlin, Germany (2014).PUB
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2685988Jakobi, T., Brinkrolf, K., Tauch, A., Noll, T., Stoye, J., Pühler, A., Goesmann, A.: Discovery of transcription start sites in the Chinese hamster genome by next-generation RNA sequencing. Journal of Biotechnology. 190, 64-75 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2676552Becker, J., Timmermann, C., Rupp, O., Albaum, S., Brinkrolf, K., Goesmann, A., Pühler, A., Tauch, A., Noll, T.: Transcriptome analyses of CHO cells with the next-generation microarray CHO41K: Development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR(3.). Journal of biotechnology. 178, 23-31 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2701280Noll, T., Pühler, A., Weisshaar, B., Wendisch, V.F.: The Genomics Revolution and its Impact on Future Biotechnology. Journal of Biotechnology. 190, : 1 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656773Rupp, O., Becker, J., Brinkrolf, K., Timmermann, C., Borth, N., Pühler, A., Noll, T., Goesmann, A.: Construction of a Public CHO Cell Line Transcript Database Using Versatile Bioinformatics Analysis Pipelines. PLoS ONE. 9, : e85568 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2679670Rath, A.G., Rehberg, M., Janke, R., Genzel, Y., Scholz, S., Noll, T., Rose, T., Sandig, V., Reichl, U.: The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells. Journal of Biotechnology. 178, 43-53 (2014).PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2615581Brinkrolf, K., Rupp, O., Laux, H., Kollin, F., Ernst, W., Linke, B., Kofler, R., Romand, S., Hesse, F., Budach, W.E., Galosy, S., Müller, D., Noll, T., Wienberg, J., Jostock, T., Leonard, M., Grillari, J., Tauch, A., Goesmann, A., Helk, B., Mott, J.E., Pühler, A., Borth, N.: Chinese hamster genome sequenced from sorted chromosomes. Nature Biotechnology. 31, 694-695 (2013).PUB | DOI | WoS | PubMed | Europe PMC
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2577265Klenke, C., Widera, D., Engelen, T., Müller, J., Noll, T., Niehaus, K., Schmitz, M., Kaltschmidt, B., Kaltschmidt, C.: Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS ONE. 8, : e65280 (2013).PUB | PDF | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2351519Lenger, J., Schröder, M., Ennemann, E., Müller, B., Wong, C.-H., Noll, T., Dierks, T., Hanson, S.R., Sewald, N.: Evaluation of sulfatase-directed quinone methide traps for proteomics. Bioorganic & Medicinal Chemistry. 20, 622-627 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2553404Carrondo, M.J.T., Alves, P.M., Carinhas, N., Glassey, J., Hesse, F., Merten, O.-W., Micheletti, M., Noll, T., Oliveira, R., Reichl, U., Staby, A., Teixeira, A.P., Weichert, H., Mandenius, C.-F.: How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal. 7, 1522-1529 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2424989Beckmann, T., Krämer, O., Klausing, S., Heinrich, C., Thüte, T., Büntemeyer, H., Hoffrogge, R., Noll, T.: Effects of high passage cultivation on CHO cells: a global analysis. Applied Microbiology Biotechnology. 94, 659-671 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2501364Meleady, P., Hoffrogge, R., Henry, M., Rupp, O., Bort, J.H., Clarke, C., Brinkrolf, K., Kelly, S., Müller, B., Doolan, P., Hackl, M., Beckmann, T., Noll, T., Grillari, J., Barron, N., Pühler, A., Clynes, M., Borth, N.: Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics. Biotechnology and Bioengineering. 109, 1386-1394 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2478526Hackl, M., Jadhav, V., Jakobi, T., Rupp, O., Brinkrolf, K., Goesmann, A., Pühler, A., Noll, T., Borth, N., Grillari, J.: Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines. Journal of Biotechnology. 158, 151-155 (2012).PUB | DOI | WoS | PubMed | Europe PMC
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2544205Barradas, O.P., Jandt, U., Da Minh Phan, L., Villanueva, M.E., Schaletzky, M., Rath, A., Freund, S., Reichl, U., Skerhutt, E.M., Scholz, S., Noll, T., Sandig, V., Poertner, R., Zeng, A.-P.: Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Engineering In Life Sciences. 12, 518-528 (2012).PUB | DOI | WoS
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375038Beckmann, T., Thüte, T., Heinrich, C., Büntemeyer, H., Noll, T.: Proteomic and metabolomic characterization of CHO DP-12 cell lines with different high passage histories. BMC Proceedings. 5, : P92 (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375605Klausing, S., Krämer, O., Noll, T.: Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment – comparative transcriptome analysis with CHO cDNA microarrays. BMC Proceedings. 5, : P98 (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2453760Heinrich, C., Timo, W., Christina, K., Northoff, S., Noll, T.: Growth characterization of CHO DP-12 cell lines with different high passage histories. In: Hansjörg, H. (ed.) BMC Proceedings. BMC Proceedings. 5, BioMed Central (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453768Becker, J., Timmermann, C., Jakobi, T., Rupp, O., Szczepanowski, R., Hackl, M., Goesmann, A., Tauch, A., Borth, N., Grillari, J., Pühler, A., Noll, T., Brinkrolf, K.: Next-generation sequencing of the CHO cell transcriptome. BMC Proceedings. 5, P6 (2011).PUB | DOI
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2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453752Volmer, M., Gettmann, J., Scholz, S., Büntemeyer, H., Noll, T.: A method for metabolomic sampling of suspended animal cells using fast filtration. BMC Proceedings. 5, 95 (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442810Skerhutt, E.M., Scholz, S., Sandig, V., Hoffrogge, R., Noll, T.: Analysis of the mitochondrial subproteome of the human cell line AGE1.HN – a contribution to a systems biology approach. BMC Proceedings. 5, (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442843Skerhutt, E.M., Scholz, S., Niklas, J., Rath, A., Platas Barradas, O., Jandt, U., Sandig, V., Rose, T., Pörtner, R., Reichl, U., Zeng, A.-P., Heinzle, E., Noll, T.: Characterisation of cultivation of the human cell line AGE1.HN.AAT. BMC Proceedings. 5, (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447643Scholz, S., Luebbecke, M., Rath, A., Schräder, E.M., Rose, T., Büntemeyer, H., Scheper, T., Reichl, U., Noll, T.: Characterization of the human AGE1.HN cell line: a systems biology approach. BMC Proceedings. 5, (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447654Platas Barradas, O., Jandt, U., Da Minh Phan, L., Villanueva, M., Rath, A., Reichl, U., Schräder, E.M., Scholz, S., Noll, T., Sandig, V., Pörtner, R., Zeng, A.-P.: Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture. BMC Proceedings. 5, (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2289895Niklas, J., Skerhutt, E.M., Sandig, V., Noll, T., Heinzle, E.: Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioprocess and Biosystems Engineering. 34, 533-545 (2011).PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375051Heinrich, C., Beckmann, T., Büntemeyer, H., Noll, T.: Utilization of multifrequency permittivity measurements in addition to biomass monitoring. BMC Proceedings. 5, (2011).PUB | DOI | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396576Becker, J., Hackel, M., Jakobi, T., Rupp, O., Schneider, J., Szczepanowski, R., Bekel, T., Borth, N., Goesmann, A., Grillari, J., Kaltschmidt, C., Noll, T., Pühler, A., Tauch, A., Brinkrolf, K.: Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Journal of Biotechnology. 156, 227-235 (2011).PUB | DOI | WoS | PubMed | Europe PMC
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2094364Volmer, M., Northoff, S., Scholz, S., Thüte, T., Büntemeyer, H., Noll, T.: Fast filtration for metabolome sampling of suspended animal cells. Biotechnology Letters. 33, 495-502 (2011).PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396494Nottorf, T., Büntemeyer, H., Siwiora Brenke, S., Lütkemeyer, D., Loa, A., Noll, T., Lehmann, J.: An integrated production process for human growth hormone. In: Noll, T. and European Society of Animal Cell Technology (eds.) ESACT Proceedings. ESACT proceedings. 4, p. 205-208. Springer, Dordrecht (2010).PUB
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396499Bäckström, M., Karlsson, H., Gätgens, J., Noll, T., Hansson, G.C.: O-glycans on recombinant MUC1 produced in CHO K1 cells becomes less sialylated with increased productivity as determined by LC ESI MS. In: Noll, T. and European Society of Animal Cell Technology (eds.) ESACT Proceedings. ESACT proceedings. 4, p. 285-288. Springer, Dordrecht (2010).PUB
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396502Wiendahl, C., Brandner, J.J., Klein, B., Küppers, C., Luo, B., Ritchie, S., Mazurek, S., Scheefers, H., Noll, T., Schygulla, U., Oldiges, M.: Metabolome analysis in mammalian cells: Development and application of a sampling technique. In: Noll, T. and European Society of Animal Cell Technology (eds.) ESACT Proceedings. ESACT proceedings. 4, p. 413-420. Springer, Dordrecht (2010).PUB | DOI
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2010 | Herausgeber*in Sammelwerk | Veröffentlicht | PUB-ID: 2453825Noll, T., European Society of Animal Cell Technology eds: Cells and Culture. ESACT Proceedings, 4. Springer, Dordrecht (2010).PUB
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396497Wingens, M., Gätgens, J., Hoffrogge, R., Noll, T.: Proteomic characterization of a glucose-limited CHO perfusion process-analysis of metabolic changes and increase in productivity. In: Noll, T. and European Society of Animal Cell Technology (eds.) ESACT Proceedings. ESACT proceedings. 4, p. 265-269. Springer, Dordrecht (2010).PUB
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396489Krämer, O., Klausing, S., Noll, T.: Methods in mammalian cell line engineering: from random mutagenesis to sequence specific approaches. Applied Microbiology and Biotechnology. 88, 425-436 (2010).PUB | DOI | WoS | PubMed | Europe PMC
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2010 | Konferenzbeitrag | PUB-ID: 2396573Northoff, S., Büntemeyer, H., Sandig, V., Zietze, S., Noll, T.: Characterization of the novel human AGE1hn cell line for production of recombinant proteins. In: Noll, T. and European Society of Animal Cell Technology (eds.) ESACT Proceedings. ESACT proceedings. 4, p. 693-697. Spinger, Dordrecht (2010).PUB
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1929340Burgemeister, S., Nattkemper, T.W., Noll, T., Hoffrogge, R., Flaschel, E.: CellViCAM-Cell viability classification for animal cell cultures using dark field micrographs. JOURNAL OF BIOTECHNOLOGY. 149, 310-316 (2010).PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1590674Widera, D., Zander, C., Heidbreder, M., Kasperek, Y., Noll, T., Seitz, O., Saldamli, B., Sudhoff, H., Sader, R., Kaltschmidt, C., Kaltschmidt, B.: Adult Palatum as a Novel Source of Neural Crest-Related Stem Cells. Stem Cells. 27, 1899-1910 (2009).PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396483Kubitzki, T., Minör, D., Mackfeld, U., Noll, T.: Application of immobilized bovine enterokinase in repetitive fusion protein cleavage for the production of MUC1. Journal of Biotechnology. 4, 1610-1618 (2009).PUB | DOI | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395472Magin, S., Körfer, N., Partenheimer, H., Lange, C., Zander, A., Noll, T.: Primary cells as feeder cells for clinical co-culture expansion of human hematopoietic stem cells from umbilical cord blood – a comparative study. Stem Cell and Development. 18, 173-186 (2009).PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395445Sihlbom, C., van Dijk Härd, I., Lidell, M., Noll, T., Hansson, G., Bäckström, M.: Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry. Glycobiology. 19, 375-381 (2009).PUB | DOI | WoS | PubMed | Europe PMC
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1633988Batista, F.R.X., Moraes, A.M., Büntemeyer, H., Noll, T.: Influence of culture conditions on recombinant Drosophila melanogaster S2 cells producing rabies virus glycoprotein cultivated in serum-free medium. BIOLOGICALS. 37, 108-118 (2009).PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592705Grimshaw, M.J., Papazisis, K., Picco, G., Bohnenkamp, H., Noll, T., Taylor-Papadimitriou, J., Burchell, J.: Immunisation with 'naive' syngeneic dendritic cells protects mice from tumour challenge. British Journal of Cancer. 98, 784-791 (2008).PUB | DOI | WoS | PubMed | Europe PMC
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592236Kubitzki, T., Noll, T., Luetz, S.: Immobilisation of bovine enterokinase and application of the immobilised enzyme in fusion protein cleavage. BIOPROCESS AND BIOSYSTEMS ENGINEERING. 31, 173-182 (2008).PUB | DOI | WoS | PubMed | Europe PMC
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1595232Wiendahl, C., Brandner, J.J., Kueppers, C., Luo, B., Schygulla, U., Noll, T., Oldiges, M.: A microstructure heat exchanger for quenching the metabolism of mammalian cells. CHEMICAL ENGINEERING & TECHNOLOGY. 30, 322-328 (2007).PUB | DOI | WoS
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395430Brockmeier, U., Caspers, M., Freudl, R., Jockwer, A., Noll, T., Eggert, T.: Systematic Screening of All Signal Peptides from Bacillus subtilis: A Powerful Strategy in Optimizing Heterologous Protein Secretion in Gram-positive Bacteria. Journal of Molecular Biology. 362, 393-402 (2006).PUB | DOI | WoS | PubMed | Europe PMC
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2006 | Zeitschriftenaufsatz | PUB-ID: 2395413Sewell, R., Dalziel, M., Hansson, G., Noll, T., Clausen, H., Burchell, J., Taylor-Papadimitriou, J.: Human ST6GalNAcI localizes throughout the Golgi and is responsible for the expression of the sialyl-Tn O-glycan in breast cancers. Journal of Biological Chemistry. 281, 3586-3594 (2006).PUB
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2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395377Bohnenkamp, H., Noll, T.: Process development for standardized generation of monocyte-derived dendritic cells: Applicability in breast cancer immunotherapy. ESACT Proceedings. 2, p. 221-227. Springer (2005).PUB
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395286Bohnenkamp, H., Burchell, J., Taylor-Papadimitriou, J., Noll, T.: Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells. Journal of Immunological Methods. 294, 67-80 (2005).PUB | DOI | WoS | PubMed | Europe PMC
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2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395363Fischbach, K., Noll, T.: Membrane-separated cocultivation of cord blood hematopoietic stem cells with stromal cell lines. ESACT Proceedings. 2, p. 269-271. Springer (2005).PUB
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395387Rughetti, A., Pellicciotta, I., Biffoni, M., Backström, M., Noll, T., Hansson, G., Clausen, H., Burchell, J., Taylor-Papadimitriou, J., Nuti, M.: Recombinant tumor associated MUC1 impairs differentiation and function of Dendritic Cells. Journal of Immunology. 174, 7764-7772 (2005).PUB
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2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395311Link, T., Essers, R., Zörner, K., de Graaf, A., Bäckström, M., Hansson, G., Noll, T.: Development of metabolically optimized fermentation process based on glucose-limited CHO perfusion culture. ESACT Proceedings. 2, p. 423-430. Springer (2005).PUB
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2004 | Zeitschriftenaufsatz | PUB-ID: 2395241Link, T., Backstrom, M., Graham, R., Essers, R., Zörner, K., Gätgens, J., Burchell, J., Taylor-Papadimitriou, J., Hansson, G., Noll, T.: Bioprocess development for a recombinant Mucin-1 fusion protein expressed by CHO cells in protein-free medium. Journal of Biotechnology. 110, 51-62 (2004).PUB | DOI | WoS | PubMed | Europe PMC
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395163Bäckström, M., Link, T., Olson, F.J., Karlsson, H., Graham, R., Picco, G., Burchell, J., Taylor-Papadimitriou, J., Noll, T.: Recombinant MUC1 with breast cancer-like O-glycosylation produced in large amounts in CHO-K1 cells. Biochemical Journal. 376, 677-686 (2003).PUB
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395226Noll, T.: Stammzellen – Möglichkeiten ihrer Expansion am Beispiel hämatopoetischer Stammzellen aus Nabelschnurblut. Med Klin. 98, 7-10 (2003).PUB
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395236Bohnenkamp, H., Noll, T.: Process Development for standardized generation of mature monocyte-derived dendritic cells suitable for clinical application, Cytotechnology. Cytotechnology. 42, 121-131 (2003).PUB
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394881Noll, T., Jelinek, N., Schmidt, S., Biselli, M., Wandrey, M.: Cultivation of Hematopoietic Stem and Progenitor Cells: Biochemical Engineering Aspects. Advances in Biochemical Engineering and Biotechnology. 74, 111-128 (2002).PUB
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394913Noll, T., Eisenkrätzer, D., Kiesewetter, A., Dinter, A., Zeng, S., Wandrey, C., Biselli, M., Berger, E.G.: Improved product formation in high density Chinese hamster ovary cell cultures transfected at confluency. Biotechnological letters. 24, 861-866 (2002).PUB
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394956Bohnenkamp, H., Hilbert, U., Noll, T.: Bioprocess Development for the Cultivation of human T-lymphocytes in a clinical scale. Cytotechnology. 38, 135-145 (2002).PUB
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2002 | Zeitschriftenaufsatz | PUB-ID: 2395110Paul, W., Kribben, T., Gätgens, J., de Graaf, A., Marx, A., Noll, T., Wandrey, C.: 'Identifizierung von Stoffwechsellimitierungen mit Hilfe der metabolic flux analysis am Beispiel des Nukleotidstoffwechsels von rekombinanten BHK-Zellen. Chemie Ingenieur Technik. 74, (2002).PUB
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395044Link, T., Zörner, K., Backström, M., Hansson, G., Wandrey, C., Noll, T.: Integrierte Bioprozessentwicklung zur Produktion eines potentiellen Tumorvaccins in rekombinanten CHO-Zellen. Chemie Ingenieur Technik. 74, (2002).PUB
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2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393293Bohnenkamp, H., Hilbert, U., Noll, T.: Bioprocess Development for the cultivation of human T-lymphocytes. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden (2001).PUB
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2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2394851Paul, W., de Graaf, A., Marx, A., Wagner, R., Noll, T.: Metabolic flux analysis in mammalian cells - network modelling as an example for metabolic design in recombinant BHK cells. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden (2001).PUB
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2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393315Hilbert, U., Biselli, M., Noll, T.: Cultivation of human CMV-specific lymphocytes - an example for adoptive immunoterapy. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden (2001).PUB
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393281Noll, T.: A cell culture reactor for the on-line evaluation of radiopharmaceuticals: Evaluation of the lumped constant of FDG in human glioma cells. Journal of Nuclear Medicine. 41, 556-564 (2000).PUB
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393268Noll, T., M, B.: Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells. Journal of Biotechnology. 63, 187-198 (1998).PUB
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1997 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393237Noll, T., Biselli, M., Wandrey, C.: On-line biomass monitoring of immobilized hybridoma cells by dielectrical measurements. Presented at the 14th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Portugal (1997).PUB