100 Publikationen
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2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2979009Klimpel, Maximilian, Terrao, Monica, Ching, Nilakshi, Climenti, Vanessa, Noll, Thomas, Pirzas, Vicky, and Laux, Holger. 2023. “Development of a perfusion process for continuous lentivirus production using stable suspension producer cell lines”. Biotechnology and Bioengineering.
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2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2962032Romanova, Nadiya, Schelletter, Louise, Hoffrogge, Raimund, and Noll, Thomas. 2022. “Hyperosmolality in CHO cell culture: effects on the proteome”. Applied Microbiology and Biotechnology 106: 2569–2586.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2963556Romanova, Nadiya, Schmitz, Julian, Strakeljahn, Marie, Grünberger, Alexander, Bahnemann, Janina, and Noll, Thomas. 2022. “Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response”. Cells 11 (11): 1763.
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2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2966624Hertel, Oliver, Neuss, Anne, Busche, Tobias, Brandt, David, Kalinowski, Jörn, Bahnemann, Janina, and Noll, Thomas. 2022. “Enhancing stability of recombinant CHO cells by CRISPR/Cas9-mediated site-specific integration into regions with distinct histone modifications”. Frontiers in Bioengineering and Biotechnology 10.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952449Witte, Kaya E., Hertel, Oliver, Windmöller, Beatrice Ariane, Helweg, Laureen, Höving, Anna L., Knabbe, Cornelius, Busche, Tobias, et al. 2021. “Nanopore Sequencing Reveals Global Transcriptome Signatures of Mitochondrial and Ribosomal Gene Expressions in Various Human Cancer Stem-like Cell Populations”. Cancers 13 (5): 1136.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2954736Keysberg, Christoph, Hertel, Oliver, Schelletter, Louise, Busche, Tobias, Sochart, Chiara, Kalinowski, Jörn, Hoffrogge, Raimund, Otte, Kerstin, and Noll, Thomas. 2021. “Exploring the molecular content of CHO exosomes during bioprocessing”. Applied Microbiology and Biotechnology 105 (9): 3673-3689.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2955090Schmitz, Julian, Hertel, Oliver, Yermakov, Boris, Noll, Thomas, and Grünberger, Alexander. 2021. “Growth and eGFP-production of CHO-K1 suspension cells cultivated from single-cell to laboratory scale”. Frontiers in Bioengineering and Biotechnology 9: 716343.
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2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2953580Budde, Dana, Albano, Gian-Luca, Noll, Thomas, and Jurkiewicz, Elke. 2021. “Interaction of leachable model compounds and their impact on Chinese hamster ovary cell cultivation”. Biotechnology Progress: e3150.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952639Romanova, Nadiya, Niemann, Tarek, Greiner, Johannes, Kaltschmidt, Barbara, Kaltschmidt, Christian, and Noll, Thomas. 2021. “Hyperosmolality in CHO Culture: Effects on cellular behavior and morphology”. Biotechnology and Bioengineering 118 (6): 2348-2359.
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2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949089Schmitz, Julian, Täuber, Sarah, Westerwalbesloh, Christoph, von Lieres, Eric, Noll, Thomas, and Grünberger, Alexander. 2021. “Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution”. Biotechnology and Bioengineering 118 (2): 992-1005.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944311Schelletter, Louise, Hertel, Oliver, Antar, Shareef Jarvi, Scherling, Christian, Lattig, Jens, Noll, Thomas, and Hoffrogge, Raimund. 2020. “A Positive Pressure Workstation for Semi Automated Peptide Purification of Complex Proteomic Samples.”. Rapid communications in mass spectrometry 35 (2): e8873.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948753Beatson, Richard, Graham, Rosalind, Grundland Freile, Fabio, Cozzetto, Domenico, Kannambath, Shichina, Pfeifer, Ester, Woodman, Natalie, et al. 2020. “Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype”. Communications biology 3 (1): 644.
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2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945942Pries, Antonia, Brachtvogel, Louise, Noll, Thomas, and Hoffrogge, Raimund. 2020. “Impact of NaBu and RA on histones and nuclear signaling in CHO cells”, BMC Proceedings, 14 (Suppl 5): P-159.
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2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945943Schelletter, Louise, Noll, Thomas, and Hoffrogge, Raimund. 2020. “Media supplement induced signaling in CHO cells via triple SILAC-MS”, BMC Proceedings, 14 (Suppl 5): P-565.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945107Coronel, Juliana, Gränicher, Gwendal, Sandig, Volker, Noll, Thomas, Genzel, Yvonne, and Reichl, Udo. 2020. “Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion Mode”. Frontiers in Bioengineering and Biotechnology 8: 672.
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2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944324Budde, Dana, Maier, Tanja Verena, Jurkiewicz, Elke, Pahl, Ina, Hauk, Armin, Tauscher, Eric, Gorls, Helmar, Noll, Thomas, and Menzel, Roberto. 2020. “Identification and evaluation of cell- growth-inhibiting bDtBPP-analogue degradation products from phosphite antioxidants used in polyolefin bioprocessing materials.”. Analytical and bioanalytical chemistry 412 (19): 4505-4518.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936490Seeger, Bettina, Mentz, Almut, Knebel, Constanze, Schmidt, Flavia, Bednarz, Hanna, Niehaus, Karsten, Albaum, Stefan, et al. 2019. “Assessment of mixture toxicity of (tri)azoles and their hepatotoxic effects in vitro by means of omics technologies.”. Archives of toxicology 93 (8): 2321-2333.
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2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934600Krattenmacher, Florian, Heermann, Tamara, Calvet, Amandine, Krawczyk, Bartlomiej, and Noll, Thomas. 2019. “Effect of manufacturing temperature and storage duration on stability of chemically defined media measured with LC-MS/MS”. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 94 (4): 1144-1155.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2938369Coronel, Juliana, Heinrich, Christoph, Klausing, Sandra, Noll, Thomas, Figueredo-Cardero, Alvio, and Castilho, Leda R. 2019. “Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production.”. Biotechnology progress 36 (1): e2915.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937250Schelletter, Louise, Albaum, Stefan, Walter, Stefan, Noll, Thomas, and Hoffrogge, Raimund. 2019. “Clonal variations in CHO IGF signaling investigated by SILAC-based phosphoproteomics and LFQ-MS”. Applied microbiology and biotechnology 103 (19): 8127-8143.
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2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933358Schmitz, Julian, Noll, Thomas, and Grünberger, Alexander. 2019. “Heterogeneity Studies of Mammalian Cells for Bioproduction. From Tools to Application”. Trends in Biotechnology 37 (6): 645-660.
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2018 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945946Brachtvogel, Louise, Walter, Stefan, Noll, Thomas, and Hoffrogge, Raimund. 2018. “MS-SILAC approach for phosphoproteomics of IGF signaling in producer CHO cells”, BMC Proceedings, 12 ( Suppl. 1): 3.
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2018 | Konferenzbeitrag | PUB-ID: 2933363Schmitz, Julian, Noll, Thomas, and Grünberger, Alexander. 2018. “Towards Microfluidic Single-Cell Cultivation of Mammalian Cell Lines”. Presented at the Young Scientist Cell Culture Biotechnology Retreat, Laupheim .
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2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933359Schmitz, Julian, Kerkhoff, Yannic, Noll, Thomas, Kohlheyer, Dietrich, and Grünberger, Alexander. 2018. “Towards dynamic single-cell cultivation systems for industrially relevant mammalian cell lines”. Presented at the BioProcessing Days 2018, Recklinghausen .
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2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933362Schmitz, Julian, Kerkhoff, Yannic, Noll, Thomas, and Grünberger, Alexander. 2018. “Dynamic microfluidical single-cell cultivation of mammalian cell lines. From experiment to analysis”. Presented at the CeBiTec Symposium 2018, Bielefeld .
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2915619Romanova, Nadiya, and Noll, Thomas. 2017. “Engineered and Natural Promoters and Chromatin-Modifying Elements for Recombinant Protein Expression in CHO Cells”. Biotechnology Journal 13 (3): e1700232.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2911396Müller, B., Heinrich, C., Jabs, W., Kaspar-Schönefeld, S., Schmidt, Anica, Wehmeier, Nadine, Albaum, Stefan, Baessmann, C., Noll, Thomas, and Hoffrogge, Raimund. 2017. “Label-free protein quantification of sodium butyrate treated CHO cells by ESI-UHR-TOF-MS”. Journal of Biotechnology 257: 87-98.
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2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2914045Wippermann, Anna, and Noll, Thomas. 2017. “DNA methylation in CHO cells”. Journal of Biotechnology 258 (SI): 206-210.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906640Coronel, Juliana, Klausing, Sandra, Heinrich, Christoph, Noll, Thomas, Figueredo-Cardero, Alvio, and Castilho, Leda R. 2016. “Valeric acid supplementation combined to mild hypothermia increases productivity in CHO cell cultivations”. Biochemical Engineering Journal 114: 101-109.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907079Wippermann, Anna, Rupp, Oliver, Brinkrolf, Karina, Hoffrogge, Raimund, and Noll, Thomas. 2016. “Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells”. Journal of Biotechnology 257: 150-161.
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906641Beatson, Richard, Tajadura-Ortega, Virginia, Achkova, Daniela, Picco, Gianfranco, Tsourouktsoglou, Theodora-Dorita, Klausing, Sandra, Hillier, Matthew, et al. 2016. “The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9”. Nature Immunology 17 (11): 1273-1281.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718767Wingens, Marc, Gätgens, Jochem, Schmidt, Anica, Albaum, Stefan, Büntemeyer, Heino, Noll, Thomas, and Hoffrogge, Raimund. 2015. “2D-DIGE screening of high-productive CHO cells under glucose limitation — Basic changes in the proteome equipment and hints for epigenetic effects”. Journal of Biotechnology 201: 86-97.
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2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718773Wippermann, Anna, Rupp, Oliver, Brinkrolf, Karina, Hoffrogge, Raimund, and Noll, Thomas. 2015. “The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells”. Journal of Biotechnology 199: 38-46.
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2015 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2902782Knebel, C., Marx-Stoelting, P., Pfeil, R., Seeger, B., Steinberg, P., Mentz, Almut, Bednarz, Hanna, et al. 2015. “Multi-level omics analysis of combination effects of (tri-)azoles in a set of different cell lines”, Toxicology Letters, 238 (2): S355.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656819Wippermann, Anna, Klausing, Sandra, Rupp, Oliver, Albaum, Stefan, Büntemeyer, Heino, Noll, Thomas, and Hoffrogge, Raimund. 2014. “Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells”. Applied Microbiology and Biotechnology 98 (2): 579-589.
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2014 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2694187Brinkrolf, Karina, Hoffrogge, Raimund, Hackl, Matthias, Tauch, Andreas, Baumann, Martina, Noll, Thomas, Goesmann, Alexander, Pühler, Alfred, and Borth, Nicole. 2014. “Functional -Omics for Cell Lines and Processes - The -Omics Technologies on the Example of CHO Cells”. In Animal Cell Biotechnology In Biologics Production, ed. Hansjörg Hauser and Roland Wagner, 702. Berlin, Germany: Walter de Gruyter.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2685988Jakobi, Tobias, Brinkrolf, Karina, Tauch, Andreas, Noll, Thomas, Stoye, Jens, Pühler, Alfred, and Goesmann, Alexander. 2014. “Discovery of transcription start sites in the Chinese hamster genome by next-generation RNA sequencing”. Journal of Biotechnology 190: 64-75.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2676552Becker, Jennifer, Timmermann, Christina, Rupp, Oliver, Albaum, Stefan, Brinkrolf, Karina, Goesmann, Alexander, Pühler, Alfred, Tauch, Andreas, and Noll, Thomas. 2014. “Transcriptome analyses of CHO cells with the next-generation microarray CHO41K: Development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR(3.)”. Journal of biotechnology 178: 23-31.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2701280Noll, Thomas, Pühler, Alfred, Weisshaar, Bernd, and Wendisch, Volker F. 2014. “The Genomics Revolution and its Impact on Future Biotechnology”. Journal of Biotechnology 190: 1.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656773Rupp, Oliver, Becker, Jennifer, Brinkrolf, Karina, Timmermann, Christina, Borth, Nicole, Pühler, Alfred, Noll, Thomas, and Goesmann, Alexander. 2014. “Construction of a Public CHO Cell Line Transcript Database Using Versatile Bioinformatics Analysis Pipelines”. PLoS ONE 9 (1): e85568.
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2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2679670Rath, Alexander G., Rehberg, Markus, Janke, Robert, Genzel, Yvonne, Scholz, Sebastian, Noll, Thomas, Rose, Thomas, Sandig, Volker, and Reichl, Udo. 2014. “The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells”. Journal of Biotechnology 178: 43-53.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2615581Brinkrolf, Karina, Rupp, Oliver, Laux, Holger, Kollin, Florian, Ernst, Wolfgang, Linke, Burkhard, Kofler, Rudolf, et al. 2013. “Chinese hamster genome sequenced from sorted chromosomes”. Nature Biotechnology 31 (8): 694-695.
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2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2577265Klenke, Christin, Widera, Darius, Engelen, Thomas, Müller, Janine, Noll, Thomas, Niehaus, Karsten, Schmitz, M., Kaltschmidt, Barbara, and Kaltschmidt, Christian. 2013. “Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons”. PLoS ONE 8 (6): e65280.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2351519Lenger, Janina, Schröder, Marius, Ennemann, Eva, Müller, Benjamin, Wong, C.-H., Noll, Thomas, Dierks, Thomas, Hanson, Sarah R., and Sewald, Norbert. 2012. “Evaluation of sulfatase-directed quinone methide traps for proteomics”. Bioorganic & Medicinal Chemistry 20 (2): 622-627.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2553404Carrondo, Manuel J. T., Alves, Paula M., Carinhas, Nuno, Glassey, Jarka, Hesse, Friedemann, Merten, Otto-Wilhelm, Micheletti, Martina, et al. 2012. “How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?”. Biotechnology Journal 7 (12): 1522-1529.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2424989Beckmann, Tim, Krämer, Oliver, Klausing, Sandra, Heinrich, Christoph, Thüte, Tobias, Büntemeyer, Heino, Hoffrogge, Raimund, and Noll, Thomas. 2012. “Effects of high passage cultivation on CHO cells: a global analysis”. Applied Microbiology Biotechnology 94 (3): 659-671.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2501364Meleady, Paula, Hoffrogge, Raimund, Henry, Michael, Rupp, Oliver, Bort, Juan Hernandez, Clarke, Colin, Brinkrolf, Karina, et al. 2012. “Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics”. Biotechnology and Bioengineering 109 (6): 1386-1394.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2478526Hackl, Matthias, Jadhav, Vaibhav, Jakobi, Tobias, Rupp, Oliver, Brinkrolf, Karina, Goesmann, Alexander, Pühler, Alfred, Noll, Thomas, Borth, Nicole, and Grillari, Johannes. 2012. “Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines”. Journal of Biotechnology 158 (3): 151-155.
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2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2544205Barradas, Oscar Platas, Jandt, Uwe, Da Minh Phan, Linh, Villanueva, Mario E., Schaletzky, Martin, Rath, Alexander, Freund, Susann, et al. 2012. “Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture”. Engineering In Life Sciences 12 (5): 518-528.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375038Beckmann, Tim, Thüte, Tobias, Heinrich, Christoph, Büntemeyer, Heino, and Noll, Thomas. 2011. “Proteomic and metabolomic characterization of CHO DP-12 cell lines with different high passage histories”, BMC Proceedings, 5 (Suppl 8): P92.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375605Klausing, Sandra, Krämer, Oliver, and Noll, Thomas. 2011. “Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment – comparative transcriptome analysis with CHO cDNA microarrays”, BMC Proceedings, 5 (Suppl 8): P98 .
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2453760Heinrich, Christoph, Timo, Wolf, Christina, Kropp, Northoff, Stefan, and Noll, Thomas. 2011. “Growth characterization of CHO DP-12 cell lines with different high passage histories”. In BMC Proceedings, ed. Hauser Hansjörg. Vol. 5. BMC Proceedings. BioMed Central: P29.
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2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453768Becker, Jennifer, Timmermann, Christina, Jakobi, Tobias, Rupp, Oliver, Szczepanowski, Rafael, Hackl, Matthias, Goesmann, Alexander, et al. 2011. “Next-generation sequencing of the CHO cell transcriptome”, BMC Proceedings, 5 (Suppl. 8): P6.
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2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453752Volmer, Martin, Gettmann, Julia, Scholz, Sebastian, Büntemeyer, Heino, and Noll, Thomas. 2011. “A method for metabolomic sampling of suspended animal cells using fast filtration”, BMC Proceedings, 5 (8): 95.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442810Skerhutt, Eva Maria, Scholz, Sebastian, Sandig, Volker, Hoffrogge, Raimund, and Noll, Thomas. 2011. “Analysis of the mitochondrial subproteome of the human cell line AGE1.HN – a contribution to a systems biology approach”, BMC Proceedings, 5 (8).
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442843Skerhutt, Eva Maria, Scholz, Sebastian, Niklas, Jens, Rath, Alexander, Platas Barradas, Oscar, Jandt, Uwe, Sandig, Volker, et al. 2011. “Characterisation of cultivation of the human cell line AGE1.HN.AAT”, BMC Proceedings, 5 (8).
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447643Scholz, Sebastian, Luebbecke, Miriam, Rath, Alexander, Schräder, Eva Maria, Rose, Thomas, Büntemeyer, Heino, Scheper, Thomas, Reichl, Udo, and Noll, Thomas. 2011. “Characterization of the human AGE1.HN cell line: a systems biology approach”, BMC Proceedings, 5 (8).
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447654Platas Barradas, Oscar, Jandt, Uwe, Da Minh Phan, Linh, Villanueva, Mario, Rath, Alexander, Reichl, Udo, Schräder, Eva Maria, et al. 2011. “Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture”, BMC Proceedings, 5 (8).
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2289895Niklas, Jens, Skerhutt, Eva Maria, Sandig, Volker, Noll, Thomas, and Heinzle, Elmar. 2011. “Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis”. Bioprocess and Biosystems Engineering 34 (5): 533-545.
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2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375051Heinrich, Christoph, Beckmann, Tim, Büntemeyer, Heino, and Noll, Thomas. 2011. “Utilization of multifrequency permittivity measurements in addition to biomass monitoring”, BMC Proceedings, 5 (Suppl 8).
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396576Becker, Jennifer, Hackel, M, Jakobi, Tobias, Rupp, Oliver, Schneider, Jessica, Szczepanowski, Rafael, Bekel, Thomas, et al. 2011. “Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing”. Journal of Biotechnology 156 (3): 227-235.
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2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2094364Volmer, Martin, Northoff, Stefan, Scholz, Sebastian, Thüte, Tobias, Büntemeyer, Heino, and Noll, Thomas. 2011. “Fast filtration for metabolome sampling of suspended animal cells”. Biotechnology Letters 33 (3): 495-502.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396494Nottorf, Tobias, Büntemeyer, Heino, Siwiora Brenke, Sonja, Lütkemeyer, Dirk, Loa, Alexander, Noll, Thomas, and Lehmann, Jürgen. 2010. “An integrated production process for human growth hormone”. In ESACT Proceedings, ed. Thomas Noll and European Society of Animal Cell Technology, 4:205-208. ESACT proceedings. Dordrecht : Springer.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396499Bäckström, Malin, Karlsson, Hasse, Gätgens, Jochem, Noll, Thomas, and Hansson, Gunnar C. 2010. “O-glycans on recombinant MUC1 produced in CHO K1 cells becomes less sialylated with increased productivity as determined by LC ESI MS”. In ESACT Proceedings, ed. Thomas Noll and European Society of Animal Cell Technology, 4:285-288. ESACT proceedings. Dordrecht : Springer.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396502Wiendahl, Christiane, Brandner, Jürgen J, Klein, Bianca, Küppers, Claudia, Luo, Bing, Ritchie, Steve, Mazurek, Sabine, et al. 2010. “Metabolome analysis in mammalian cells: Development and application of a sampling technique”. In ESACT Proceedings, ed. Thomas Noll and European Society of Animal Cell Technology, 4:413-420. ESACT proceedings. Dordrecht: Springer.
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2010 | Herausgeber*in Sammelwerk | Veröffentlicht | PUB-ID: 2453825Noll, Thomas, and European Society of Animal Cell Technology, eds. 2010. Cells and Culture. Vol. 4. ESACT Proceedings. Dordrecht : Springer.
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2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396497Wingens, Marc, Gätgens, Jochem, Hoffrogge, Raimund, and Noll, Thomas. 2010. “Proteomic characterization of a glucose-limited CHO perfusion process-analysis of metabolic changes and increase in productivity”. In ESACT Proceedings, ed. Thomas Noll and European Society of Animal Cell Technology, 4:265-269. ESACT proceedings. Dordrecht : Springer.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396489Krämer, Oliver, Klausing, Sandra, and Noll, Thomas. 2010. “Methods in mammalian cell line engineering: from random mutagenesis to sequence specific approaches”. Applied Microbiology and Biotechnology 88 (2): 425-436.
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2010 | Konferenzbeitrag | PUB-ID: 2396573Northoff, Stefan, Büntemeyer, Heino, Sandig, Volker, Zietze, S, and Noll, Thomas. 2010. “Characterization of the novel human AGE1hn cell line for production of recombinant proteins”. In ESACT Proceedings, ed. Thomas Noll and European Society of Animal Cell Technology, 4:693-697. ESACT proceedings. Dordrecht : Spinger.
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2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1929340Burgemeister, Sebastian, Nattkemper, Tim Wilhelm, Noll, Thomas, Hoffrogge, Raimund, and Flaschel, Erwin. 2010. “CellViCAM-Cell viability classification for animal cell cultures using dark field micrographs”. JOURNAL OF BIOTECHNOLOGY 149 (4): 310-316.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1590674Widera, Darius, Zander, Christin, Heidbreder, Meike, Kasperek, Yvonne, Noll, Thomas, Seitz, Oliver, Saldamli, Belma, et al. 2009. “Adult Palatum as a Novel Source of Neural Crest-Related Stem Cells”. Stem Cells 27 (8): 1899-1910.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396483Kubitzki, T, Minör, D, Mackfeld, U, and Noll, Thomas. 2009. “Application of immobilized bovine enterokinase in repetitive fusion protein cleavage for the production of MUC1”. Journal of Biotechnology 4 (11): 1610-1618.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395472Magin, S, Körfer, N, Partenheimer, H, Lange, C, Zander, A, and Noll, Thomas. 2009. “Primary cells as feeder cells for clinical co-culture expansion of human hematopoietic stem cells from umbilical cord blood – a comparative study”. Stem Cell and Development 18 (1): 173-186.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395445Sihlbom, C, van Dijk Härd, I, Lidell, M, Noll, Thomas, Hansson, G, and Bäckström, M. 2009. “Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry”. Glycobiology 19 (4): 375-381.
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2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1633988Batista, Fabiana R. X., Moraes, Angela M., Büntemeyer, Heino, and Noll, Thomas. 2009. “Influence of culture conditions on recombinant Drosophila melanogaster S2 cells producing rabies virus glycoprotein cultivated in serum-free medium”. BIOLOGICALS 37 (2): 108-118.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592705Grimshaw, M. J., Papazisis, K., Picco, G., Bohnenkamp, H., Noll, Thomas, Taylor-Papadimitriou, J., and Burchell, J. 2008. “Immunisation with 'naive' syngeneic dendritic cells protects mice from tumour challenge”. British Journal of Cancer 98 (4): 784-791.
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592236Kubitzki, Tina, Noll, Thomas, and Luetz, Stephan. 2008. “Immobilisation of bovine enterokinase and application of the immobilised enzyme in fusion protein cleavage”. BIOPROCESS AND BIOSYSTEMS ENGINEERING 31 (3): 173-182.
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2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1595232Wiendahl, C., Brandner, J. J., Kueppers, C., Luo, B., Schygulla, U., Noll, Thomas, and Oldiges, M. 2007. “A microstructure heat exchanger for quenching the metabolism of mammalian cells”. CHEMICAL ENGINEERING & TECHNOLOGY 30 (3): 322-328.
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2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395430Brockmeier, U, Caspers, M, Freudl, R, Jockwer, A, Noll, Thomas, and Eggert, T. 2006. “Systematic Screening of All Signal Peptides from Bacillus subtilis: A Powerful Strategy in Optimizing Heterologous Protein Secretion in Gram-positive Bacteria”. Journal of Molecular Biology 362 (3): 393-402.
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2006 | Zeitschriftenaufsatz | PUB-ID: 2395413Sewell, R, Dalziel, M, Hansson, G, Noll, Thomas, Clausen, H, Burchell, J, and Taylor-Papadimitriou, J. 2006. “Human ST6GalNAcI localizes throughout the Golgi and is responsible for the expression of the sialyl-Tn O-glycan in breast cancers”. Journal of Biological Chemistry 281: 3586-3594.
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2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395377Bohnenkamp, H, and Noll, Thomas. 2005. “Process development for standardized generation of monocyte-derived dendritic cells: Applicability in breast cancer immunotherapy”. In ESACT Proceedings, 2:221-227. Springer.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395286Bohnenkamp, H, Burchell, J, Taylor-Papadimitriou, J, and Noll, Thomas. 2005. “Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells”. Journal of Immunological Methods 294 (1-2): 67-80.
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2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395363Fischbach, K, and Noll, Thomas. 2005. “Membrane-separated cocultivation of cord blood hematopoietic stem cells with stromal cell lines”. In ESACT Proceedings, 2:269-271. Springer.
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2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395387Rughetti, A, Pellicciotta, I, Biffoni, M, Backström, M, Noll, Thomas, Hansson, G, Clausen, H, Burchell, J, Taylor-Papadimitriou, J, and Nuti, M. 2005. “Recombinant tumor associated MUC1 impairs differentiation and function of Dendritic Cells”. Journal of Immunology 174 (12): 7764-7772.
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2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395311Link, T, Essers, R, Zörner, K, de Graaf, A, Bäckström, M, Hansson, G, and Noll, Thomas. 2005. “Development of metabolically optimized fermentation process based on glucose-limited CHO perfusion culture”. In ESACT Proceedings, 2:423-430. Springer.
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2004 | Zeitschriftenaufsatz | PUB-ID: 2395241Link, T, Backstrom, M, Graham, R, Essers, R, Zörner, K, Gätgens, J, Burchell, J, Taylor-Papadimitriou, J, Hansson, G, and Noll, Thomas. 2004. “Bioprocess development for a recombinant Mucin-1 fusion protein expressed by CHO cells in protein-free medium”. Journal of Biotechnology 110 (1): 51-62.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395163Bäckström, M, Link, T, Olson, FJ, Karlsson, H, Graham, R, Picco, G, Burchell, J, Taylor-Papadimitriou, J, and Noll, Thomas. 2003. “Recombinant MUC1 with breast cancer-like O-glycosylation produced in large amounts in CHO-K1 cells”. Biochemical Journal 376: 677-686.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395226Noll, Thomas. 2003. “Stammzellen – Möglichkeiten ihrer Expansion am Beispiel hämatopoetischer Stammzellen aus Nabelschnurblut”. Med Klin 98 (Suppl II): 7-10.
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2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395236Bohnenkamp, H, and Noll, Thomas. 2003. “Process Development for standardized generation of mature monocyte-derived dendritic cells suitable for clinical application, Cytotechnology”. Cytotechnology 42: 121-131.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394881Noll, Thomas, Jelinek, N, Schmidt, S, Biselli, M, and Wandrey, M. 2002. “Cultivation of Hematopoietic Stem and Progenitor Cells: Biochemical Engineering Aspects”. Advances in Biochemical Engineering and Biotechnology 74: 111-128.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394913Noll, Thomas, Eisenkrätzer, D, Kiesewetter, A, Dinter, A, Zeng, S, Wandrey, C, Biselli, M, and Berger, EG. 2002. “Improved product formation in high density Chinese hamster ovary cell cultures transfected at confluency”. Biotechnological letters 24: 861-866.
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394956Bohnenkamp, H, Hilbert, U, and Noll, Thomas. 2002. “Bioprocess Development for the Cultivation of human T-lymphocytes in a clinical scale”. Cytotechnology 38: 135-145.
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2002 | Zeitschriftenaufsatz | PUB-ID: 2395110Paul, W, Kribben, T, Gätgens, J, de Graaf, A, Marx, A, Noll, Thomas, and Wandrey, C. 2002. “'Identifizierung von Stoffwechsellimitierungen mit Hilfe der metabolic flux analysis am Beispiel des Nukleotidstoffwechsels von rekombinanten BHK-Zellen”. Chemie Ingenieur Technik 74 (690).
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2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395044Link, T, Zörner, K, Backström, M, Hansson, G, Wandrey, C, and Noll, Thomas. 2002. “Integrierte Bioprozessentwicklung zur Produktion eines potentiellen Tumorvaccins in rekombinanten CHO-Zellen”. Chemie Ingenieur Technik 74 (671).
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2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393293Bohnenkamp, H, Hilbert, U, and Noll, Thomas. 2001. “Bioprocess Development for the cultivation of human T-lymphocytes”. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden , ed. E Lindner-Olsson, N Chatzissavidou, and E Lüllau, 503-508. Kluwer Academic.
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2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2394851Paul, W, de Graaf, A, Marx, A, Wagner, R, and Noll, Thomas. 2001. “Metabolic flux analysis in mammalian cells - network modelling as an example for metabolic design in recombinant BHK cells”. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden , ed. E Lindner-Olsson, N Chatzissavidou, and N Lüllau, 136-141. Kluwer Academic.
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2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393315Hilbert, U, Biselli, M, and Noll, Thomas. 2001. “Cultivation of human CMV-specific lymphocytes - an example for adoptive immunoterapy”. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden , ed. E Lindner-Olsson, N Chatzissavidou, and E Lüllau, 558-561. Kluwer Academic.
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2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393281Noll, Thomas. 2000. “A cell culture reactor for the on-line evaluation of radiopharmaceuticals: Evaluation of the lumped constant of FDG in human glioma cells”. Journal of Nuclear Medicine 41 (3): 556-564.
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1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393268Noll, Thomas, and M, Biselli. 1998. “Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells.”. Journal of Biotechnology 63: 187-198.
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1997 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393237Noll, Thomas, Biselli, M, and Wandrey, C. 1997. “On-line biomass monitoring of immobilized hybridoma cells by dielectrical measurements”. Presented at the 14th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Portugal , ed. Carrondo M.J.T., 289-294. Kluwer.