100 Publikationen

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  • [100]
    2023 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2979009 OA
    Klimpel M, Terrao M, Ching N, et al. Development of a perfusion process for continuous lentivirus production using stable suspension producer cell lines. Biotechnology and Bioengineering. 2023.
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  • [99]
    2022 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2962032 OA
    Romanova N, Schelletter L, Hoffrogge R, Noll T. Hyperosmolality in CHO cell culture: effects on the proteome. Applied Microbiology and Biotechnology. 2022;106: 2569–2586.
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  • [98]
    2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2963556 OA
    Romanova N, Schmitz J, Strakeljahn M, Grünberger A, Bahnemann J, Noll T. Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response. Cells. 2022;11(11): 1763.
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  • [97]
    2022 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2966624 OA
    Hertel O, Neuss A, Busche T, et al. Enhancing stability of recombinant CHO cells by CRISPR/Cas9-mediated site-specific integration into regions with distinct histone modifications. Frontiers in Bioengineering and Biotechnology. 2022;10.
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  • [96]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952449 OA
    Witte KE, Hertel O, Windmöller BA, et al. Nanopore Sequencing Reveals Global Transcriptome Signatures of Mitochondrial and Ribosomal Gene Expressions in Various Human Cancer Stem-like Cell Populations. Cancers. 2021;13(5): 1136.
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  • [95]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2954736 OA
    Keysberg C, Hertel O, Schelletter L, et al. Exploring the molecular content of CHO exosomes during bioprocessing. Applied Microbiology and Biotechnology. 2021;105(9):3673-3689.
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  • [94]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2955090 OA
    Schmitz J, Hertel O, Yermakov B, Noll T, Grünberger A. Growth and eGFP-production of CHO-K1 suspension cells cultivated from single-cell to laboratory scale. Frontiers in Bioengineering and Biotechnology. 2021;9: 716343.
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  • [93]
    2021 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2953580 OA
    Budde D, Albano G-L, Noll T, Jurkiewicz E. Interaction of leachable model compounds and their impact on Chinese hamster ovary cell cultivation. Biotechnology Progress. 2021: e3150.
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  • [92]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2952639 OA
    Romanova N, Niemann T, Greiner J, Kaltschmidt B, Kaltschmidt C, Noll T. Hyperosmolality in CHO Culture: Effects on cellular behavior and morphology. Biotechnology and Bioengineering. 2021;118(6):2348-2359.
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  • [91]
    2021 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2949089 OA
    Schmitz J, Täuber S, Westerwalbesloh C, von Lieres E, Noll T, Grünberger A. Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution. Biotechnology and Bioengineering. 2021;118(2):992-1005.
    PUB | Dateien verfügbar | DOI | WoS | PubMed | Europe PMC | Preprint
     
  • [90]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944311 OA
    Schelletter L, Hertel O, Antar SJ, et al. A Positive Pressure Workstation for Semi Automated Peptide Purification of Complex Proteomic Samples. Rapid communications in mass spectrometry. 2020;35(2): e8873.
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  • [89]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2948753
    Beatson R, Graham R, Grundland Freile F, et al. Cancer-associated hypersialylated MUC1 drives the differentiation of human monocytes into macrophages with a pathogenic phenotype. Communications biology. 2020;3(1): 644.
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  • [88]
    2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945942
    Pries A, Brachtvogel L, Noll T, Hoffrogge R. Impact of NaBu and RA on histones and nuclear signaling in CHO cells. BMC Proceedings. 2020;14(Suppl 5): P-159.
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  • [87]
    2020 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945943
    Schelletter L, Noll T, Hoffrogge R. Media supplement induced signaling in CHO cells via triple SILAC-MS. BMC Proceedings. 2020;14(Suppl 5): P-565.
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  • [86]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2945107 OA
    Coronel J, Gränicher G, Sandig V, Noll T, Genzel Y, Reichl U. Application of an Inclined Settler for Cell Culture-Based Influenza A Virus Production in Perfusion Mode. Frontiers in Bioengineering and Biotechnology. 2020;8: 672.
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  • [85]
    2020 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2944324
    Budde D, Maier TV, Jurkiewicz E, et al. Identification and evaluation of cell- growth-inhibiting bDtBPP-analogue degradation products from phosphite antioxidants used in polyolefin bioprocessing materials. Analytical and bioanalytical chemistry. 2020;412(19):4505-4518.
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  • [84]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2936490
    Seeger B, Mentz A, Knebel C, et al. Assessment of mixture toxicity of (tri)azoles and their hepatotoxic effects in vitro by means of omics technologies. Archives of toxicology. 2019;93(8):2321-2333.
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  • [83]
    2019 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2934600
    Krattenmacher F, Heermann T, Calvet A, Krawczyk B, Noll T. Effect of manufacturing temperature and storage duration on stability of chemically defined media measured with LC-MS/MS. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY. 2019;94(4):1144-1155.
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  • [82]
    2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2938369
    Coronel J, Heinrich C, Klausing S, Noll T, Figueredo-Cardero A, Castilho LR. Perfusion process combining low temperature and valeric acid for enhanced recombinant factor VIII production. Biotechnology progress. 2019;36(1):e2915.
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  • [81]
    2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2937250
    Schelletter L, Albaum S, Walter S, Noll T, Hoffrogge R. Clonal variations in CHO IGF signaling investigated by SILAC-based phosphoproteomics and LFQ-MS. Applied microbiology and biotechnology. 2019;103(19):8127-8143.
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  • [80]
    2019 | Zeitschriftenaufsatz | E-Veröff. vor dem Druck | PUB-ID: 2933358
    Schmitz J, Noll T, Grünberger A. Heterogeneity Studies of Mammalian Cells for Bioproduction. From Tools to Application. Trends in Biotechnology. 2019;37(6):645-660.
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  • [79]
    2018 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2945946
    Brachtvogel L, Walter S, Noll T, Hoffrogge R. MS-SILAC approach for phosphoproteomics of IGF signaling in producer CHO cells. BMC Proceedings. 2018;12( Suppl. 1): 3.
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  • [78]
    2018 | Konferenzbeitrag | PUB-ID: 2933363
    Schmitz J, Noll T, Grünberger A. Towards Microfluidic Single-Cell Cultivation of Mammalian Cell Lines. Presented at the Young Scientist Cell Culture Biotechnology Retreat, Laupheim.
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  • [77]
    2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933359
    Schmitz J, Kerkhoff Y, Noll T, Kohlheyer D, Grünberger A. Towards dynamic single-cell cultivation systems for industrially relevant mammalian cell lines. Presented at the BioProcessing Days 2018, Recklinghausen.
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  • [76]
    2018 | Kurzbeitrag Konferenz / Poster | PUB-ID: 2933362
    Schmitz J, Kerkhoff Y, Noll T, Grünberger A. Dynamic microfluidical single-cell cultivation of mammalian cell lines. From experiment to analysis. Presented at the CeBiTec Symposium 2018, Bielefeld.
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  • [75]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2915619
    Romanova N, Noll T. Engineered and Natural Promoters and Chromatin-Modifying Elements for Recombinant Protein Expression in CHO Cells. Biotechnology Journal. 2017;13(3): e1700232.
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  • [74]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2911396
    Müller B, Heinrich C, Jabs W, et al. Label-free protein quantification of sodium butyrate treated CHO cells by ESI-UHR-TOF-MS. Journal of Biotechnology. 2017;257:87-98.
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  • [73]
    2017 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2914045
    Wippermann A, Noll T. DNA methylation in CHO cells. Journal of Biotechnology. 2017;258(SI):206-210.
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  • [72]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906640
    Coronel J, Klausing S, Heinrich C, Noll T, Figueredo-Cardero A, Castilho LR. Valeric acid supplementation combined to mild hypothermia increases productivity in CHO cell cultivations. Biochemical Engineering Journal. 2016;114:101-109.
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  • [71]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907079
    Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T. Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology. 2016;257:150-161.
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  • [70]
    2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2906641
    Beatson R, Tajadura-Ortega V, Achkova D, et al. The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9. Nature Immunology. 2016;17(11):1273-1281.
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  • [69]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718767
    Wingens M, Gätgens J, Schmidt A, et al. 2D-DIGE screening of high-productive CHO cells under glucose limitation — Basic changes in the proteome equipment and hints for epigenetic effects. Journal of Biotechnology. 2015;201:86-97.
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  • [68]
    2015 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2718773
    Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T. The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells. Journal of Biotechnology. 2015;199:38-46.
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  • [67]
    2015 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2902782
    Knebel C, Marx-Stoelting P, Pfeil R, et al. Multi-level omics analysis of combination effects of (tri-)azoles in a set of different cell lines. Toxicology Letters. 2015;238(2):S355.
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  • [66]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656819
    Wippermann A, Klausing S, Rupp O, et al. Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells. Applied Microbiology and Biotechnology. 2014;98(2):579-589.
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  • [65]
    2014 | Sammelwerksbeitrag | Veröffentlicht | PUB-ID: 2694187
    Brinkrolf K, Hoffrogge R, Hackl M, et al. Functional -Omics for Cell Lines and Processes - The -Omics Technologies on the Example of CHO Cells. In: Hauser H, Wagner R, eds. Animal Cell Biotechnology In Biologics Production. Berlin, Germany: Walter de Gruyter; 2014: 702.
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  • [64]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2685988
    Jakobi T, Brinkrolf K, Tauch A, et al. Discovery of transcription start sites in the Chinese hamster genome by next-generation RNA sequencing. Journal of Biotechnology. 2014;190:64-75.
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  • [63]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2676552
    Becker J, Timmermann C, Rupp O, et al. Transcriptome analyses of CHO cells with the next-generation microarray CHO41K: Development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR(3.). Journal of biotechnology. 2014;178:23-31.
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  • [62]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2701280
    Noll T, Pühler A, Weisshaar B, Wendisch VF. The Genomics Revolution and its Impact on Future Biotechnology. Journal of Biotechnology. 2014;190: 1.
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  • [61]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2656773
    Rupp O, Becker J, Brinkrolf K, et al. Construction of a Public CHO Cell Line Transcript Database Using Versatile Bioinformatics Analysis Pipelines. PLoS ONE. 2014;9(1): e85568.
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  • [60]
    2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2679670
    Rath AG, Rehberg M, Janke R, et al. The influence of cell growth and enzyme activity changes on intracellular metabolite dynamics in AGE1.HN.AAT cells. Journal of Biotechnology. 2014;178:43-53.
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  • [59]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2615581
    Brinkrolf K, Rupp O, Laux H, et al. Chinese hamster genome sequenced from sorted chromosomes. Nature Biotechnology. 2013;31(8):694-695.
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  • [58]
    2013 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2577265 OA
    Klenke C, Widera D, Engelen T, et al. Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons. PLoS ONE. 2013;8(6): e65280.
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  • [57]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2351519
    Lenger J, Schröder M, Ennemann E, et al. Evaluation of sulfatase-directed quinone methide traps for proteomics. Bioorganic & Medicinal Chemistry. 2012;20(2):622-627.
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  • [56]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2553404
    Carrondo MJT, Alves PM, Carinhas N, et al. How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal. 2012;7(12):1522-1529.
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  • [55]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2424989
    Beckmann T, Krämer O, Klausing S, et al. Effects of high passage cultivation on CHO cells: a global analysis. Applied Microbiology Biotechnology. 2012;94(3):659-671.
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  • [54]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2501364
    Meleady P, Hoffrogge R, Henry M, et al. Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics. Biotechnology and Bioengineering. 2012;109(6):1386-1394.
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  • [53]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2478526
    Hackl M, Jadhav V, Jakobi T, et al. Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines. Journal of Biotechnology. 2012;158(3):151-155.
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  • [52]
    2012 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2544205
    Barradas OP, Jandt U, Da Minh Phan L, et al. Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture. Engineering In Life Sciences. 2012;12(5):518-528.
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  • [51]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375038
    Beckmann T, Thüte T, Heinrich C, Büntemeyer H, Noll T. Proteomic and metabolomic characterization of CHO DP-12 cell lines with different high passage histories. BMC Proceedings. 2011;5(Suppl 8): P92.
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  • [50]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375605
    Klausing S, Krämer O, Noll T. Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment – comparative transcriptome analysis with CHO cDNA microarrays. BMC Proceedings. 2011;5(Suppl 8): P98 .
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  • [49]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2453760
    Heinrich C, Timo W, Christina K, Northoff S, Noll T. Growth characterization of CHO DP-12 cell lines with different high passage histories. In: Hansjörg H, ed. BMC Proceedings. BMC Proceedings. Vol 5. BioMed Central; 2011.
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  • [48]
    2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453768
    Becker J, Timmermann C, Jakobi T, et al. Next-generation sequencing of the CHO cell transcriptome. BMC Proceedings. 2011;5(Suppl. 8):P6.
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  • [47]
    2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2453752
    Volmer M, Gettmann J, Scholz S, Büntemeyer H, Noll T. A method for metabolomic sampling of suspended animal cells using fast filtration. BMC Proceedings. 2011;5(8):95.
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  • [46]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442810
    Skerhutt EM, Scholz S, Sandig V, Hoffrogge R, Noll T. Analysis of the mitochondrial subproteome of the human cell line AGE1.HN – a contribution to a systems biology approach. BMC Proceedings. 2011;5(8).
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  • [45]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2442843
    Skerhutt EM, Scholz S, Niklas J, et al. Characterisation of cultivation of the human cell line AGE1.HN.AAT. BMC Proceedings. 2011;5(8).
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  • [44]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447643
    Scholz S, Luebbecke M, Rath A, et al. Characterization of the human AGE1.HN cell line: a systems biology approach. BMC Proceedings. 2011;5(8).
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  • [43]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2447654
    Platas Barradas O, Jandt U, Da Minh Phan L, et al. Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture. BMC Proceedings. 2011;5(8).
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  • [42]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2289895
    Niklas J, Skerhutt EM, Sandig V, Noll T, Heinzle E. Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioprocess and Biosystems Engineering. 2011;34(5):533-545.
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  • [41]
    2011 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2375051
    Heinrich C, Beckmann T, Büntemeyer H, Noll T. Utilization of multifrequency permittivity measurements in addition to biomass monitoring. BMC Proceedings. 2011;5(Suppl 8).
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  • [40]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396576
    Becker J, Hackel M, Jakobi T, et al. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Journal of Biotechnology. 2011;156(3):227-235.
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  • [39]
    2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2094364
    Volmer M, Northoff S, Scholz S, Thüte T, Büntemeyer H, Noll T. Fast filtration for metabolome sampling of suspended animal cells. Biotechnology Letters. 2011;33(3):495-502.
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  • [38]
    2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396494
    Nottorf T, Büntemeyer H, Siwiora Brenke S, et al. An integrated production process for human growth hormone. In: Noll T, European Society of Animal Cell Technology, eds. ESACT Proceedings. ESACT proceedings. Vol 4. Dordrecht : Springer; 2010: 205-208.
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  • [37]
    2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396499
    Bäckström M, Karlsson H, Gätgens J, Noll T, Hansson GC. O-glycans on recombinant MUC1 produced in CHO K1 cells becomes less sialylated with increased productivity as determined by LC ESI MS. In: Noll T, European Society of Animal Cell Technology, eds. ESACT Proceedings. ESACT proceedings. Vol 4. Dordrecht : Springer; 2010: 285-288.
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  • [36]
    2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396502
    Wiendahl C, Brandner JJ, Klein B, et al. Metabolome analysis in mammalian cells: Development and application of a sampling technique. In: Noll T, European Society of Animal Cell Technology, eds. ESACT Proceedings. ESACT proceedings. Vol 4. Dordrecht: Springer; 2010: 413-420.
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  • [35]
    2010 | Herausgeber*in Sammelwerk | Veröffentlicht | PUB-ID: 2453825
    Noll T, European Society of Animal Cell Technology, eds. Cells and Culture. ESACT Proceedings. Vol 4. Dordrecht : Springer; 2010.
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  • [34]
    2010 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2396497
    Wingens M, Gätgens J, Hoffrogge R, Noll T. Proteomic characterization of a glucose-limited CHO perfusion process-analysis of metabolic changes and increase in productivity. In: Noll T, European Society of Animal Cell Technology, eds. ESACT Proceedings. ESACT proceedings. Vol 4. Dordrecht : Springer; 2010: 265-269.
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  • [33]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396489
    Krämer O, Klausing S, Noll T. Methods in mammalian cell line engineering: from random mutagenesis to sequence specific approaches. Applied Microbiology and Biotechnology. 2010;88(2):425-436.
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  • [32]
    2010 | Konferenzbeitrag | PUB-ID: 2396573
    Northoff S, Büntemeyer H, Sandig V, Zietze S, Noll T. Characterization of the novel human AGE1hn cell line for production of recombinant proteins. In: Noll T, European Society of Animal Cell Technology, eds. ESACT Proceedings. ESACT proceedings. Vol 4. Dordrecht : Spinger; 2010: 693-697.
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  • [31]
    2010 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1929340
    Burgemeister S, Nattkemper TW, Noll T, Hoffrogge R, Flaschel E. CellViCAM-Cell viability classification for animal cell cultures using dark field micrographs. JOURNAL OF BIOTECHNOLOGY. 2010;149(4):310-316.
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  • [30]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1590674
    Widera D, Zander C, Heidbreder M, et al. Adult Palatum as a Novel Source of Neural Crest-Related Stem Cells. Stem Cells. 2009;27(8):1899-1910.
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  • [29]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2396483
    Kubitzki T, Minör D, Mackfeld U, Noll T. Application of immobilized bovine enterokinase in repetitive fusion protein cleavage for the production of MUC1. Journal of Biotechnology. 2009;4(11):1610-1618.
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  • [28]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395472
    Magin S, Körfer N, Partenheimer H, Lange C, Zander A, Noll T. Primary cells as feeder cells for clinical co-culture expansion of human hematopoietic stem cells from umbilical cord blood – a comparative study. Stem Cell and Development. 2009;18(1):173-186.
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  • [27]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395445
    Sihlbom C, van Dijk Härd I, Lidell M, Noll T, Hansson G, Bäckström M. Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry. Glycobiology. 2009;19(4):375-381.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [26]
    2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1633988
    Batista FRX, Moraes AM, Büntemeyer H, Noll T. Influence of culture conditions on recombinant Drosophila melanogaster S2 cells producing rabies virus glycoprotein cultivated in serum-free medium. BIOLOGICALS. 2009;37(2):108-118.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [25]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592705
    Grimshaw MJ, Papazisis K, Picco G, et al. Immunisation with 'naive' syngeneic dendritic cells protects mice from tumour challenge. British Journal of Cancer. 2008;98(4):784-791.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [24]
    2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1592236
    Kubitzki T, Noll T, Luetz S. Immobilisation of bovine enterokinase and application of the immobilised enzyme in fusion protein cleavage. BIOPROCESS AND BIOSYSTEMS ENGINEERING. 2008;31(3):173-182.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [23]
    2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1595232
    Wiendahl C, Brandner JJ, Kueppers C, et al. A microstructure heat exchanger for quenching the metabolism of mammalian cells. CHEMICAL ENGINEERING & TECHNOLOGY. 2007;30(3):322-328.
    PUB | DOI | WoS
     
  • [22]
    2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395430
    Brockmeier U, Caspers M, Freudl R, Jockwer A, Noll T, Eggert T. Systematic Screening of All Signal Peptides from Bacillus subtilis: A Powerful Strategy in Optimizing Heterologous Protein Secretion in Gram-positive Bacteria. Journal of Molecular Biology. 2006;362(3):393-402.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [21]
    2006 | Zeitschriftenaufsatz | PUB-ID: 2395413
    Sewell R, Dalziel M, Hansson G, et al. Human ST6GalNAcI localizes throughout the Golgi and is responsible for the expression of the sialyl-Tn O-glycan in breast cancers. Journal of Biological Chemistry. 2006;281:3586-3594.
    PUB
     
  • [20]
    2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395377
    Bohnenkamp H, Noll T. Process development for standardized generation of monocyte-derived dendritic cells: Applicability in breast cancer immunotherapy. In: ESACT Proceedings. Vol 2. Springer; 2005: 221-227.
    PUB
     
  • [19]
    2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395286
    Bohnenkamp H, Burchell J, Taylor-Papadimitriou J, Noll T. Apoptosis of monocytes and the influence on yield of monocyte-derived dendritic cells. Journal of Immunological Methods. 2005;294(1-2):67-80.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [18]
    2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395363
    Fischbach K, Noll T. Membrane-separated cocultivation of cord blood hematopoietic stem cells with stromal cell lines. In: ESACT Proceedings. Vol 2. Springer; 2005: 269-271.
    PUB
     
  • [17]
    2005 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395387
    Rughetti A, Pellicciotta I, Biffoni M, et al. Recombinant tumor associated MUC1 impairs differentiation and function of Dendritic Cells. Journal of Immunology. 2005;174(12):7764-7772.
    PUB
     
  • [16]
    2005 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2395311
    Link T, Essers R, Zörner K, et al. Development of metabolically optimized fermentation process based on glucose-limited CHO perfusion culture. In: ESACT Proceedings. Vol 2. Springer; 2005: 423-430.
    PUB
     
  • [15]
    2004 | Zeitschriftenaufsatz | PUB-ID: 2395241
    Link T, Backstrom M, Graham R, et al. Bioprocess development for a recombinant Mucin-1 fusion protein expressed by CHO cells in protein-free medium. Journal of Biotechnology. 2004;110(1):51-62.
    PUB | DOI | WoS | PubMed | Europe PMC
     
  • [14]
    2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395163
    Bäckström M, Link T, Olson FJ, et al. Recombinant MUC1 with breast cancer-like O-glycosylation produced in large amounts in CHO-K1 cells. Biochemical Journal. 2003;376:677-686.
    PUB
     
  • [13]
    2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395226
    Noll T. Stammzellen – Möglichkeiten ihrer Expansion am Beispiel hämatopoetischer Stammzellen aus Nabelschnurblut. Med Klin. 2003;98(Suppl II):7-10.
    PUB
     
  • [12]
    2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395236
    Bohnenkamp H, Noll T. Process Development for standardized generation of mature monocyte-derived dendritic cells suitable for clinical application, Cytotechnology. Cytotechnology. 2003;42:121-131.
    PUB
     
  • [11]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394881
    Noll T, Jelinek N, Schmidt S, Biselli M, Wandrey M. Cultivation of Hematopoietic Stem and Progenitor Cells: Biochemical Engineering Aspects. Advances in Biochemical Engineering and Biotechnology. 2002;74:111-128.
    PUB
     
  • [10]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394913
    Noll T, Eisenkrätzer D, Kiesewetter A, et al. Improved product formation in high density Chinese hamster ovary cell cultures transfected at confluency. Biotechnological letters. 2002;24:861-866.
    PUB
     
  • [9]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2394956
    Bohnenkamp H, Hilbert U, Noll T. Bioprocess Development for the Cultivation of human T-lymphocytes in a clinical scale. Cytotechnology. 2002;38:135-145.
    PUB
     
  • [8]
    2002 | Zeitschriftenaufsatz | PUB-ID: 2395110
    Paul W, Kribben T, Gätgens J, et al. 'Identifizierung von Stoffwechsellimitierungen mit Hilfe der metabolic flux analysis am Beispiel des Nukleotidstoffwechsels von rekombinanten BHK-Zellen. Chemie Ingenieur Technik. 2002;74(690).
    PUB
     
  • [7]
    2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2395044
    Link T, Zörner K, Backström M, Hansson G, Wandrey C, Noll T. Integrierte Bioprozessentwicklung zur Produktion eines potentiellen Tumorvaccins in rekombinanten CHO-Zellen. Chemie Ingenieur Technik. 2002;74(671).
    PUB
     
  • [6]
    2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393293
    Bohnenkamp H, Hilbert U, Noll T. Bioprocess Development for the cultivation of human T-lymphocytes. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden.
    PUB
     
  • [5]
    2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2394851
    Paul W, de Graaf A, Marx A, Wagner R, Noll T. Metabolic flux analysis in mammalian cells - network modelling as an example for metabolic design in recombinant BHK cells. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden.
    PUB
     
  • [4]
    2001 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393315
    Hilbert U, Biselli M, Noll T. Cultivation of human CMV-specific lymphocytes - an example for adoptive immunoterapy. Presented at the 17th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Sweden.
    PUB
     
  • [3]
    2000 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393281
    Noll T. A cell culture reactor for the on-line evaluation of radiopharmaceuticals: Evaluation of the lumped constant of FDG in human glioma cells. Journal of Nuclear Medicine. 2000;41(3):556-564.
    PUB
     
  • [2]
    1998 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2393268
    Noll T, M B. Dielectric spectroscopy in the cultivation of suspended and immobilized hybridoma cells. Journal of Biotechnology. 1998;63:187-198.
    PUB
     
  • [1]
    1997 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 2393237
    Noll T, Biselli M, Wandrey C. On-line biomass monitoring of immobilized hybridoma cells by dielectrical measurements. Presented at the 14th European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies, Portugal.
    PUB
     

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