52 Publikationen
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2016 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2907725Wei H, Cai H, Wu J, Wei Z, Zhang F, Huang X, Ma L, Feng L, Zhang R, Wang Y, Ragg H, Zheng Y, Zhou A (2016)PUB | DOI | WoS | PubMed | Europe PMC
Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism.
JOURNAL OF BIOLOGICAL CHEMISTRY 291(48): 24900-24911. -
2014 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2690864Sfaxi F, Scamuffa N, Lalou C, Ma J, Metrakos P, Siegfried G, Ragg H, Bikfalvi A, Calvo F, Khatib A-M (2014)PUB | DOI | WoS | PubMed | Europe PMC
Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases.
Oncotarget 5(12): 4195-4210. -
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2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2423346Wang Y, Ragg H (2011)PUB
Angiotensinogen: the multi-faceted nature of an ancient vertebrate serpin.
Presented at the 6th International Symposium on the Chemistry and Biology of Serpins, Raleigh, North Carolina. -
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2423353Börner S, Ragg H (2011)PUB | DOI | WoS | PubMed | Europe PMC
Bioinformatic approaches for the identification of serpin genes with multiple reactive site loop coding exons.
Methods in Enzymology 501: 209-222. -
2011 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 2423350Ragg H, Wang Y (2011)PUB
How control of thrombin by serpins in vertebrates arose.
In: Abstracts of the XXIII Congress of the International Society on Thrombosis and Haemostasis 57th Annual SSC Meeting, July 23-28 2011, Kyoto, Japan. Journal of Thrombosis and Haemostasis, 9. Wiley: 723. -
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948655Ragg H (2011)PUB | DOI | WoS | PubMed | Europe PMC
Intron creation and DNA repair.
Cell. Mol. Life Sci. 68(2): 235-242. -
2011 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 2307100Wang Y, Ragg H (2011)PUB | DOI | WoS | PubMed | Europe PMC
An unexpected link between angiotensinogen and thrombin.
FEBS Letters 585(14): 2395-2399. -
2009 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1784544Ragg H, Kumar A, Köster K, Bentele C, Wang Y, Frese M-A, Prib N, Krüger O (2009)PUB | PDF | DOI | WoS | PubMed | Europe PMC
Multiple gains of spliceosomal introns in a superfamily of vertebrate protease inhibitor genes.
BMC Evolutionary Biology 9(1): 208. -
2008 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 1955161Börner S, Ragg H (2008)PUB
Multitasking serpin genes in the genus Drosophila and beyond: evolution and functional diversification.
Presented at the Serpins 2008, 5th International Symposium on Serpin Biology, Structure and Function, Leuwen, Belgium. -
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2008 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1587736Börner S, Ragg H (2008)PUB | DOI | WoS | PubMed | Europe PMC
Functional diversification of a protease inhibitor gene in the genus Drosophila and its molecular basis.
GENE 415(1-2): 23-31. -
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953796Brüning M, Lummer M, Bentele C, Smolenaars MMW, Rodenburg KW, Ragg H (2007)PUB | DOI | WoS | PubMed | Europe PMC
The Spn4 gene from Drosophila melanogaster is a multipurpose defense tool directed against proteases from three different peptidase families.
Biochem. J. 401(1): 325-331. -
2007 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 1955191Bentele C, Oley M, Tödtmann U, Krüger O, Ragg H (2007)PUB
Proprotein convertase inhibiting serpins along the secretory pathway.
Presented at the Mosbacher Kolloquium der Gesellschaft für Biochemie und Molekularbiologie, Mosbach. -
2007 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1631413Ragg H (2007)PUB | DOI | WoS | PubMed | Europe PMC
The role of serpins in the surveillance of the secretory pathway.
CELL. MOL. LIFE SCI. 64(21): 2763-2770. -
2006 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953791Bentele C, Krüger O, Tödtmann U, Oley M, Ragg H (2006)PUB | DOI | WoS | PubMed | Europe PMC
A proprotein convertase-inhibiting serpin with an ER targeting signal from Branchiostoma lanceolatum, a close relative of vertebrates.
Biochem. J. 395(3): 449-456. -
2006 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 1955145Bentele C, Krüger O, Tödtmann U, Oley M, Ragg H (2006)PUB
The role of serpins along the secretory pathway: regulation of prohormone convertases and beyond.
In: Gordon Research Conferences. . -
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2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1606208Brinkmeyer S, Eckert R, Ragg H (2004)PUB | DOI | WoS | PubMed | Europe PMC
Reformable intramolecular cross-linking of the N-terminal domain of heparin cofactor II - Effects on enzyme inhibition.
EUROPEAN JOURNAL OF BIOCHEMISTRY 271(21): 4275-4283. -
2004 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953787Oley M, Letzel M, Ragg H (2004)PUB | DOI | WoS | PubMed | Europe PMC
Inhibition of furin by serpin Spn4A from Drosophila melanogaster.
FEBS Letters 577(1-2): 165-169. -
2003 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953801Eckert R, Ragg H (2003)PUB | DOI | WoS | PubMed | Europe PMC
Zinc ions promote the interaction between heparin and heparin cofactor II.
FEBS Letters 541(1-3): 121-125. -
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1615250Böhme C, Nimtz M, Grabenhorst E, Conradt HS, Strathmann A, Ragg H (2002)PUB | DOI | WoS | PubMed | Europe PMC
Tyrosine sulfation and N-glycosylation of human heparin cofactor II from plasma and recombinant Chinese hamster ovary cells and their effects on heparin binding.
EUROPEAN JOURNAL OF BIOCHEMISTRY 269(3): 977-988. -
2002 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1613937Krüger O, Ladewig J, Köster K, Ragg H (2002)PUB | DOI | WoS | PubMed | Europe PMC
Widespread occurrence of serpin genes with multiple reactive centre-containing exon cassettes in insects and nematodes.
GENE 293(1-2): 97-105. -
2001 | Kurzbeitrag Konferenz / Poster | Veröffentlicht | PUB-ID: 1955179Brinkmeyer S, Eckert R, Ragg H (2001)PUB
Evidence for allosteric activation of heparin cofactor II in the presence of heparin or dermatan sulfate.
Presented at the XVIIIth Congress of the International Society on Thrombosis and Haemostasis, Paris. -
2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1617557Ragg H, Lokot T, Kamp P-B, Atchley WR, Dress A (2001)PUB | DOI | WoS | PubMed | Europe PMC
Vertebrate serpins: Construction of a conflict-free phylogeny by combining exon-intron and diagnostic site analyses.
MOLECULAR BIOLOGY AND EVOLUTION 18(4): 577-584. -
2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1616585Atchley WR, Lokot T, Wollenberg K, Dress A, Ragg H (2001)PUB | DOI | WoS | PubMed | Europe PMC
Phylogenetic analyses of amino acid variation in the serpin proteins.
MOLECULAR BIOLOGY AND EVOLUTION 18(8): 1502-1511. -
2001 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1617446Kamp P-B, Strathmann A, Ragg H (2001)PUB | DOI | WoS | PubMed | Europe PMC
Heparin cofactor II, antithrombin-beta and their complexes with thrombin in human tissues.
THROMBOSIS RESEARCH 101(6): 483-491. -
1999 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1623326Kamp P-B, Ragg H (1999)PUB | DOI | WoS | PubMed | Europe PMC
Rapid changes in the exon/intron structure of a mammalian thrombin inhibitor gene.
GENE 229(1-2): 137-144. -
1997 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1954263Peyman A, Ragg H, Ulshöfer T, Will DW, Uhlmann E (1997)PUB
Enhanced specificity of minimally modified anti-c-myc oligonucleotides.
Nucleosides & Nucleotides 16: 1215-1219. -
1994 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953772Westrup D, Ragg H (1994)PUB
Secondary thrombin-binding site, glycosaminoglycan binding domain and reactive center region of leuserpin-2 are strongly conserved in mammalian species.
Biochim. Biophys. Acta 1217: 93-96. -
1990 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953759Ragg H, Ulshöfer T, Gerewitz J (1990)PUB
On the activation of human leuserpin-2, a thrombin inhibitor, by glycosaminoglycans.
J. Biol. Chem. 265: 5211-5218. -
1990 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953767Glauder J, Ragg H, Rauch J, Engels JW (1990)PUB
Human peptidylglycine alpha-amidating monooxygenase: cDNA cloning and functional expression of a truncated form in COS cells.
Biochem. Biophys. Res. Commun. 169: 551-558. -
1990 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1953763Ragg H, Ulshöfer T, Gerewitz J (1990)PUB
Glycosaminoglycan-mediated leuserpin-2/thrombin interaction: structure-function relationships.
J. Biol. Chem. 265: 22386-22301. -
1988 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948728Ragg H, Preibisch G (1988)PUB
Structure and expression of the gene coding for the human serpin hLS2.
J. Biol. Chem. 263: 12129-12134. -
1987 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948715Bröker M, Ragg H, Karges HE (1987)PUB
Expression of human antithrombin III in Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Biochim. Biophys. Acta 908: 203-213. -
1987 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948719Zettlmeissl G, Ragg H, Karges HE (1987)PUB
Expression of biologically active human antithrombin III in Chinese hamster ovary cells.
Bio-Technology 5: 720-725. -
1986 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948704Ragg H (1986)PUB
A new member of the plasma protease inhibitor gene family.
Nucleic Acids Res. 14: 1073-1088. -
1985 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948699Ryals J, Dierks P, Ragg H, Weissmann C (1985)PUB
A 46-nucleotide promotor segment from an IFN-alpha gene renders an unrelated promotor inducible by virus.
Cell 41: 497-507. -
1983 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948696Ragg H, Weissmann C (1983)PUB
Not more than 117 base pairs of 5'-flanking sequence are required for inducible expression of a human IFN-alpha gene.
Nature 303: 439-442. -
1983 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 1954275Ragg H, Weidle U, Mantei N, Weissmann C (1983)PUB
The induced transcription of a human IFN-alpha gene requires not more than 117 base pairs of 5'-flanking sequence.
Presented at the Second International TNO Meeting on the Biology of the Interferon System, Rotterdam. -
1983 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948675Kreuzaler F, Ragg H, Fautz E, Kuhn DN, Hahlbrock K (1983)PUB
UV-induction of chalcone synthase mRNA in cell suspension cultures of Petroselinum hortense.
Proc. Natl. Acad. Sci. USA 80: 2591-2593. -
1982 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948687Hemleben V, Frey M, Rall S, Koch M, Kittel M, Kreuzaler F, Ragg H, Fautz E, Hahlbrock K (1982)PUB
Studies on the chalcone synthase gene of two higher plants: Petroselinum hortense and Matthiola incana.
Progr. Clin. Biol. Res. 85 (Pt B): 555-566. -
1982 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1946278Wienand U, Sommer H, Schwarz Z, Shepard N, Saedler H, Kreuzaler F, Ragg H, Fautz E, Hahlbrock K (1982)PUB
A general method to identify plant structural genes among genomic DNA clones using transposable element induced mutations.
Mol. Gen. Genet. 187: 195-201. -
1982 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1948634Weissmann C, Nagata S, Boll W, Fountoulakis M, Fujisawa A, Fujisawa J-I, Haynes J, Henco K, Mantei N, Ragg H, Schein C, Schmid J, Shaw G, Streuli M, Taira H, Todokoro K, Weidle U (1982)PUB
Structure and expression of human IFN-alpha genes.
Philos. Trans. R. Soc. Lond. B 299(1094): 7-28. -
1982 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 1954292Hahlbrock K, Kreuzaler F, Ragg H, Fautz E, Kuhn DN (1982)PUB
Regulation of flavonoid and phytoalexin accumulation through mRNA and enzyme induction in cultured plant cells.
In: 33. Colloquium der Gesellschaft für Biologische Chemie. Jaenicke L (Ed); Berlin: Springer-Verlag: 34-43. -
1981 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1945081Ragg H, Kuhn DN, Hahlbrock K (1981)PUB
Coordinated regulation of 4-coumarate: CoA ligase and phenylalanine ammonia-lyase mRNAs in cultured plant cells.
J. Biol. Chem. 256: 10061-10065. -
1980 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1945070Ragg H, Hahlbrock K (1980)PUB
Messenger RNA coding for phenylalanine ammonia-lyase: Characterization and partial purification from cell suspension cultures of Petroselinum hortense.
Eur. J. Biochem. 103: 323-330. -
1979 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1945064Kreuzaler F, Ragg H, Heller W, Tesch R, Witt I, Hammer D, Hahlbrock K (1979)PUB
Flavanone synthase from Petroselinum hortense: Molecular weight, subunit composition, size of messenger RNA, and absence of panthetheinyl residue.
Eur. J. Biochem. 99: 89-96. -
1978 | Konferenzbeitrag | Veröffentlicht | PUB-ID: 1954304Hahlbrock K, Betz B, Gardiner SE, Kreuzaler F, Matern U, Ragg H, Schäfer E, Schröder J (1978)PUB
Enzyme induction in cultured cells.
Presented at the Proceedings of the 4th International Congress of Plant Tissue and Cell Culture, Calgary, Alberta, Canada. -
1977 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1945055Ragg H, Schröder J, Hahlbrock K (1977)PUB
Translation of poly(A)-containing and poly(A)-free messenger RNA for phenylalanine ammonia-lyase, a plant-specific protein, in a reticulocyte lysate.
Biochim. Biophys. Acta 474: 226-233. -
1975 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1941362Hahlbrock K, Ragg H (1975)PUB
Light-induced changes of enzyme activities in parsley suspension cultures: Effects of inhibitors of RNA and protein synthesis.
Arch. Biochem. Biophys. 166: 41-46. -
1975 | Zeitschriftenaufsatz | Veröffentlicht | PUB-ID: 1941368Ragg H, Schröder J, Hahlbrock K (1975)PUB
Poly(A)-containing RNA from Petroselinum hortense: Isolation, properties and messenger function in vitro.
Molecular Biology Reports 2: 119-127.